Digital Library/Neuropsychopharmacology – 5th Generation of Progress
Introduction
Published in 2002, the Fifth Edition synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. Nine sections focus on specific groups of disorders–disorders of development; schizophrenia and related disorders; anxiety and stress disorders; affective disorders; Alzheimer’s and other dementias; substance use disorders; impulsive and compulsive disorders; movement disorders and paroxysmal disorders; and chronobiology and sleep disorders. Each group of disorders is discussed in detail, including clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation.
Neuropsychopharmacology: The Fifth Generation of Progress Editors:
Kenneth L. Davis
Dennis Charney
Joseph T. Coyle
Charles Nemeroff
Lippincott, Williams, & Wilkins, Philadelphia, Pennsylvania, 2002
Section 1
Neurotransmitter And Signal Transduction (PDF)
Eric J. Nestler And Ronald S. Duman
Chapter 1: Acetylcholine (PDF)
Marina R. Picciotto, Meenakshi Alreja And J. David Jentsch
Chapter 2: Serotonin (PDF)
George K. Aghajanian And Elaine Sanders-Bush
Chapter 3: Opioid Peptides And Their Receptors: Overview And Function In Pain Modulation (PDF)
George K. Aghajanian And Elaine Sanders-Bush
Chapter 4: Norepinephrine (PDF)
Gary Aston-Jones
Chapter 5: Regulation Of G Protein-Coupled Receptors By Phosphorylation And Endocytosis (PDF)
Mark Von Zastrow
Chapter 6: The Diverse Roles Of L-Glutamic Acid In Brain Signal Transduction (PDF)
Joseph T. Coyle, Michael L. Leski, and John H. Morrison
Chapter 7: Corticotropin-Releasing Factor: Physiology, Pharmacology, And Role In Central Nervous System Disorders (PDF)
Errol B. De Souza And Dimitri E. Grigoriadis
Chapter 8: Neurogenesis In Adult Brain (PDF)
Fred H. Gage And Henriette Van Praag
Chapter 9: Dopamine (PDF)
Anthony A. Grace
Chapter 10: Astrocytes (PDF)
Pierre J. Magistretti And Bruce R. Ransom
Chapter 11: Synaptic Plasticity (PDF)
Robert C. Malenka
Chapter 12: Gaba (PDF)
Richard W. Olsen
Chapter 13: Substance P And Related Tachykinins (PDF)
Nadia M.J. Rupniak Mark S. Kramer
Chapter 14: Histamine (PDF)
Jean-Charles Schwartz And Jean-Michel Arrang
Chapter 15: Purinergic Neurotransmission (PDF)
Michael Williams
Chapter 16: Neurotrophic Factors And Intracellular Signal Transduction Pathways (PDF)
David S. Russell And Ronald S. Duman
Chapter 17: Regulation Of Gene Expression (PDF)
Eric J. Nestler And Steven E. Hyman
Section 2
Emerging Methods in Molecular Biology and Genetics (PDF)
Samuel H. Barondes
Chapter 18: Using Human Genomics To Advance Neuropsychopharmacology (PDF)
L. Alison Mcinnes and Nelson B. Freimer
Chapter 19: Gene Targeting And Transgenic Technologies (PDF)
Laurence H. Tecott And David S. Johnson
Chapter 20: Gene Delivery Into The Brain Using Viral Vectors (PDF)
Rachael L. Neve And William A. Carlezon, Jr
Chapter 21: Neuropsychopharmacology Of Worms And Flies (PDF)
William R. Schafer
Chapter 22: Beyond Binding: Molecular And Cell Biological Approaches To Studying G-Protein Coupled Receptors (PDF)
Gabriel A. Vargas And Mark Von Zastrow
Chapter 23: Applying Functional Genomics To Neuropsychopharmacology (PDF)
Michael Brownstein
Section 3
Emerging Imaging Technologies And Their Application To Psychiatric Research (PDF)
Robert Desimone
Chapter 24: Automated 3D Analysis Of Large Brain MRI Databases (PDF)
Alan C. Evans
Chapter 25: In Vivo Magnetic Resonance Spectroscopy Studies Of The Glutamate And GABA Neurotransmitter Cycles And Functional Neuroenergetics (PDF)
Douglas L. Rothman, Fahmeed Hyder, Nicola Sibson, Kevin L. Behar, Graeme F. Mason, Jun Shen, Ognen A. C. Petroff And Robert G. Shulman
Chapter 26: The Spatial, Temporal, And Interpretive Limits Of Functional MRI (PDF)
Peter A. Bandettini
Chapter 27: Diffusion Tensor Imaging (PDF)
Nikos Makris, G. M. Papadimitriou, A. J. Worth, Bruce G. Jenkins, L. Garrido, A. Gregory Sorensen, V. J. Wedeen, David S. Tuch, O. Wu, Merit E. Cudkowicz, V. S. Caviness Jr., B. R. Rosen And David N. Kennedy
Chapter 28: Activation Paradigms In Affective And Cognitive Neuroscience: Probing The Neuronal Circuitry Underlying Mood And Anxiety Disorders (PDF)
Richard J. Davidson
Chapter 29: Interactions Among Neuronal Systems Assessed With Functional Neuroimaging (PDF)
Christian Büchel And Karl Friston
Chapter 30: Measuring Brain Connectivity With Functional Imaging And Transcranial Magnetic Stimulation (TMS) (PDF)
Mark S. George And Daryl E. Bohning
Chapter 31: In Vivo Molecular Imaging: Ligand Development And Research Applications (PDF)
Masahiro Fujita And Robert B. Innis
Chapter 32: Event-Related Potentials And Magnetic Fields In The Human Brain (PDF)
Steven A. Hillyard And Marta Kutas
Section 4
Drug Discovery And Evaluation (PDF)
Herbert Meltzer
Chapter 33: The Role Of Preclinical Models In The Development Of Psychotropic Drugs (PDF)
Mark A. Geyer And Athina Markou
Chapter 34: Proof Of Concept: Functional Models For Drug Development In Humans (PDF)
Dean F. Wong, William Z. Potter And James R. Brasic
Chapter 35: Ethical Aspects Of Neuropsychiatric Research With Human Subjects (PDF)
Debra A. Pinals And Paul S. Appelbaum
Chapter 36: Regulatory Issues (PDF)
Paul Leber
Chapter 37: Pharmacogenomics And Personalized Therapeutics In Psychiatry (PDF)
Vural Özdemir, Vincenzo S. Basile, Mario Masellis, Pierandrea Muglia And James L. Kennedy
Chapter 38: Pharmacokinetics, Pharmacodynamics, And Drug Disposition (PDF)
David J. Greenblatt, Lisa L. Von Moltke, Jerold S. Harmatz And Richard I. Shader
Chapter 39: The Role Of Pharmaceuticals In Mental Health Care Outcomes (PDF)
Ramin Mahmoud, Chris M. Kozma, C. E. Reeder, Amy Grogg And Brian Meissner
Chapter 40: Issues In Clinical Trial Designs (PDF)
John M. Kane
Section 5
Disorders Of Development (PDF)
Joseph T. Coyle
Chapter 41: The Molecular And Cellular Genetics Of Autism (PDF)
Thomas H. Wassink, James S. Sutcliffe, Veronica J. Vieland And Joseph Piven
Chapter 42: Current And Emerging Therapeutics Of Autistic Disorder And Related Pervasive Developmental Disorders (PDF)
Christopher J. McDougle
Chapter 43: Pathophysiology Of Attention-Deficit/Hyperactivity Disorder (PDF)
Stephen V. Farone And Joseph Biederman
Chapter 44: Learning Disorders (PDF)
C. Keith Conners And Ann C. Schulte
Chapter 45: Psychosis In Childhood And Its Management (PDF)
Paramjit T. Joshi And Kenneth E. Towbin
Chapter 46: Behavioral Phenotypes Of Neurodevelopmental Disorders: Portals Into The Developing Brain (PDF)
James C. Harris
Section 6
Schizophrenia And Related Disorders (PDF)
Daniel R. Weinberger
Chapter 47: Schizophrenia: Course Over The Lifetime (PDF)
Philip D. Harvey And Michael Davidson
Chapter 48: Neurocognitive Functioning In Patients With Schizophrenia: An Overview (PDF)
Terry E. Goldberg And Michael F. Green
Chapter 49: Molecular And Population Genetics Of Schizophrenia (PDF)
Ming T. Tsuang And Michael J. Owen
Chapter 50: Animal Models Relevant To Schizophrenia Disorders (PDF)
Mark A. Geyer And Bita Moghaddam
Chapter 51: Endophenotypes In Studies Of The Genetics Of Schizophrenia (PDF)
David L. Braff And Robert Freedman
Chapter 52: Neurochemistry Of Schizophrenia: Glutamatergic Abnormalities (PDF)
James H. Meador-Woodruff And Joel E. Kleinman
Chapter 53: Neural Circuitry Approaches To Understanding The Pathophysiology Of Schizophrenia (PDF)
David A. Lewis
Chapter 54: Functional Neuroimaging In Schizophrenia (PDF)
Karen Faith Berman
Chapter 55: Structural Magnetic Resonance Imaging Studies In Schizophrenia (PDF)
Robert W. Mccarley
Chapter 56: Therapeutics Of Schizophrenia (PDF)
Seiya Miyamoto, Gary E. Duncan, Donald C. Goff And Jeffrey A. Lieberman
Chapter 57: The Economics Of The Treatment Of Schizophrenia (PDF)
Susan M. Essock, Linda K. Frisman And Nancy H. Covell
Chapter 58: Mechanism Of Action Of Atypical Antipsychotic Drugs (PDF)
Herbert Y. Meltzer
Chapter 59: Neurochemical And Neuropharmacological Imaging In Schizophrenia (PDF)
Daniel R. Weinberger And Marc Laruelle
Section 7
Anxiety And Stress Disorders (PDF)
Dennis Charney
Chapter 60: Anxiety And Stress Disorders: Course Over The Lifetime (PDF)
Murray B. Stein And Ariel J. Lang
Chapter 61: Genetic And Other Vulnerability Factors For Anxiety And Stress Disorders (PDF)
Kathleen R. Merikangas And Daniel Pine
Chapter 62: Animal Models And Endophenotypes Of Anxiety And Stress Disorders (PDF)
Vaishali P. Bakshi And Ned H. Kalin
Chapter 63: Neurobiological Basis Of Anxiety Disorders (PDF)
Dennis S. Charney And Wayne C. Drevets
Chapter 64: Neural Circuitry Of Anxiety And Stress Disorders (PDF)
Michael Davis
Chapter 65: Structural And Functional Imaging Of Anxiety And Stress Disorders (PDF)
Scott L. Rauch And Lisa M. Shin
Chapter 66: Current And Emerging Therapeutics Of Anxiety And Stress Disorders (PDF)
Jack M. Gorman, Justine M. Kent And Jeremy D. Coplan
Chapter 67: The Economic Burden Of Anxiety And Stress Disorders (PDF)
Ronald C. Kessler And Paul E. Greenberg
Chapter 68: Mechanism Of Action Of Anxiolytics (PDF)
John F. Tallman, James Cassella And John Kehne
Section 8
Affective Disorders (PDF)
Charles Nemeroff
Chapter 69: The Course Of Depression (PDF)
Robert J. Boland And Martin B. Keller
Chapter 70: Risk Factors For Major Depression And Bipolar Disorder (PDF)
Robert M. A. Hirschfeld And Myrna M. Weissman
Chapter 71: Bipolar Disorders: Review Of Molecular Genetic Linkage Studies (PDF)
Wade Berrettini
Chapter 72: Molecular And Cellular Mechanisms In Depression (PDF)
Alan F. Schatzberg, Stephen J. Garlow And Charles B. Nemeroff
Chapter 73: Neurocircuitry Of Mood Disorders (PDF)
Gregory A. Ordway, Violetta Klimek And J. John Mann
Chapter 74: Structural And Functional Imaging Of Affective Disorders (PDF)
Yvette I. Sheline And Mark A. Mintun
Chapter 75: Current And Emerging Therapeutics For Depression (PDF)
A. John Rush And Neal D. Ryan
Chapter 76: Electroconvulsive Therapy: Sixty Years Of Progress And A Comparison With Transcranial Magnetic Stimulation And Vagal Nerve Stimulation (PDF)
William M. Mcdonald, W. Vaughn Mccall And Charles M. Epstein
Chapter 77: Current And Emerging Treatments For Acute Mania And Long-Term Prophylaxis For Bipolar Disorder (PDF)
Paul E. Keck, Jr. And Husseini K. Manji
Chapter 78: Cost-Effectiveness Of The Newer Generation Of Antidepressants (PDF)
Scott W. Woods And C. Bruce Baker
Chapter 79: Mechanism Of Action Of Antidepressants And Mood Stabilizers (PDF)
Robert H. Lenox And Alan Frazer
Chapter 80: Hormonal And Gender Influences On Mood Regulation (PDF)
David R. Rubinow, Peter J. Schmidt And Catherine A. Roca
Chapter 81: Depression And The Medically Ill (PDF)
Robert G. Robinson And K. Ranga Rama Krishnan
Section 9
Alzheimer And Other Dementias (PDF)
Kenneth L. Davis
Chapter 82: Alzheimer Disease: From Earliest Symptoms To End Stage (PDF)
Richard C. Mohs And Vahram Haroutunian
Chapter 83: Molecular Genetics Of Alzheimer Disease (PDF)
S. Parvathy And Joseph D. Buxbaum
Chapter 84: Transgenic Mouse Models Of Alzheimer Disease (PDF)
Karen Duff
Chapter 85: Cell And Molecular Neuropathology Of Alzheimer Disease (PDF)
Ralph A. Nixon
Chapter 86: Structural And Functional Brain Imaging Of Alzheimer Disease (PDF)
Gary W. Small
Chapter 87: Current And Experimental Therapeutics Of Alzheimer Disease (PDF)
Kenneth L. Davis
Chapter 88: Alzheimer Disease: Treatment Of Noncognitive Behavioral Abnormalities (PDF)
Murray A. Raskind Robert F. Barnes
Chapter 89: Cost-Effectiveness Of Therapeutics For Alzheimer Disease (PDF)
Andrea Manca, Linda Davies And Alistair Burns
Chapter 90: Neuropsychiatric Manifestations Of HIV-1 Infection And AIDS (PDF)
Dwight L. Evans, Karen I. Mason, Jane Leserman, Russell Bauer And John Petitto
Chapter 91: Dementia With Lewy Bodies (PDF)
Ian G. McKeith, David Burn, John O’Brien, Robert Perry And Elaine Perry
Chapter 92: Molecular Pathophysiology Of Stroke (PDF)
Steven H. Graham And Robert W. Hickey
Chapter 93: Current And Experimental Treatment Of Stroke (PDF)
Daniel L. Small, Paul Morley And Alastair M. Buchan
Chapter 94: Tau Protein And Tauopathy (PDF)
Makoto Higuchi, John Q. Trojanowski And Virginia M.-Y. Lee
Section 10
Substance Use Disorders (PDF)
Charles P. O'Brien And Marian W. Fischman
Chapter 95: Neurocircuitry Of Addiction (PDF)
Peter W. Kalivas
Chapter 96: Molecular And Cellular Biology Of Addiction (PDF)
Kathy L. Kopnisky And Steven E. Hyman
Chapter 97: Recent Advances In Animal Models Of Drug Addiction (PDF)
Toni S. Shippenberg And George F. Koob
Chapter 98: Vulnerability Factors For Alcoholism (PDF)
Marc A. Schuckit
Chapter 99: Molecular And Cellular Genetics Of Alcohol Addiction (PDF)
Mary-Anne Enoch And David Goldman
Chapter 100: Ethanol Abuse, Dependence, And Withdrawal: Neurobiology And Clinical Implications (PDF)
John H. Krystal Boris Tabakoff
Chapter 101: Alcoholism Pharmacotherapy (PDF)
Joseph R. Volpicelli, Suchitra Krishnan-Sarin And Stephanie S. O'Malley
Chapter 102: Pathophysiology And Treatment Of Cocaine Dependence (PDF)
Thomas R. Kosten
Chapter 103: Application Of Imaging Technologies In The Investigation Of Drug Addiction (PDF)
Nora D. Volkow And Joanna S. Fowler
Chapter 104: Molecular And Cellular Neurobiology And Pathophysiology Of Opiate Addiction (PDF)
Mary Jeanne Kreek
Chapter 105: Current And Experimental Therapeutics For The Treatment Of Opioid Addiction (PDF)
Paul J. Fudala And George E. Woody
Chapter 106: Marijuana (PDF)
Billy R. Martin, William L. Dewey, And Vincenzo Di Marzo
Chapter 107: Therapeutics For Nicotine Addiction (PDF)
Reese T. Jones And Neal L. Benowitz
Chapter 108: Psychedelic Drugs (PDF)
Henry David Abraham, Una D. Mccann, And George A. Ricaurte
Chapter 109: Epidemiology Of Drug Dependence (PDF)
James C. Anthony
Chapter 110: Neuroimaging Of Cocaine Craving States: Cessation, Stimulant Administration, And Drug Cue Paradigms (PDF)
A. R. Childress, Teresa R. Franklin, J. Listerud, Paul D. Acton And Charles P. O'Brien
Section 11
Impulsive And Compulsive Disorders (PDF)
Eric Hollander
Chapter 111: The Course And Clinical Features Of Obsessive-Compulsive Disorder (PDF)
Steven A. Rasmussen And Jane L. Eisen
Chapter 112: The Pathophysiology And Genetics Of Obsessive-Compulsive Disorder (PDF)
David L. Pauls, Emanuela Mundo And James L. Kennedy
Chapter 113: Imaging And Neurocircuitry Of OCD (PDF)
David R. Rosenberg And Shauna N. Macmillan
Chapter 114: Current And Experimental Therapeutics Of OCD (PDF)
Eric Hollander And Stefano Pallanti
Chapter 115: The Behavioral Neuroscience Of Eating (PDF)
Gerard P. Smith And Nori Geary
Chapter 116: Psychopharmacology Of Eating Disorders (PDF)
Walter H. Kaye And B. Timothy Walsh
Chapter 117: Tourette Syndrome And Related Tic Disorders (PDF)
Neal R. Swerdlow And James F. Leckman
Chapter 118: Animal Models Of Aggression (PDF)
Berend Olivier And Larry J. Young
Chapter 119: Pathophysiology And Treatment Of Aggression (PDF)
Emil F. Coccaro And Larry J. Siever
Chapter 120: Pathologic Gambling And Impulse Control Disorders (PDF)
Mark N. Potenza And Eric Hollander
Chapter 121: Compulsive And Impulsive Aspects Of Self-Injurious Behavior (PDF)
Dan J. Stein, Joseph Zohar, And Daphne Simeon
Section 12
Movement Disorders And Paroxysmal Disorders (PDF)
Carol Tamminga
Chapter 122: Neurocircuitry Of Parkinson's Disease (PDF)
Thomas Wichmann And Mahlon R. Delong
Chapter 123: Pathophysiology Of Parkinson's Disease (PDF)
Michael J. Zigmond And Robert E. Burke
Chapter 124: Current And Experimental Therapeutics Of Parkinson's Disease (PDF)
Jean-Michel Gracies And C. Warren Olanow
Chapter 125: Huntington Disease (PDF)
Christopher A. Ross And Russell L. Margolis
Chapter 126: Clinical Course And Cellular Pathology Of Tardive Dyskinesia (PDF)
Carol A. Tamminga And Margaret G. Woerner
Chapter 127: Temporal Lobe Epilepsy: Renewed Emphasis On Extrahippocampal Areas (PDF)
Robert Schwarcz, Helen E. Scharfman And Edward H. Bertram
Section 13
Chronobiology And Sleep Disorders (PDF)
David J. Kupfer
Chapter 128: Basic Mechanisms Of Sleep: New Evidence On The Neuroanatomy And Neuromodulation Of The Nrem-Rem Cycle (PDF)
Edward F. Pace-Schott And J. Allan Hobson
Chapter 129: Circadian Phase Sleep And Mood Disorders (PDF)
Jacqueline D. Kloss, Martin P. Szuba And David F. Dinges
Chapter 130: Sleep Loss And Sleepiness: Physiological And Neurobehavioral Effects (PDF)
Jacqueline D. Kloss, Martin P. Szuba And David F. Dinges
Chapter 131: Pathophysiological And Pharmacologic Aspects Of The Sleep Disorder Narcolepsy (PDF)
Emmanuel Mignot And Seiji Nishino
Chapter 132: Basic Mechanisms Of Sedative/Hypnotics (PDF)
Wallace B. Mendelson
Chapter 133: Current And Experimental Therapeutics Of Insomnia (PDF)
Daniel J. Buysse And Cynthia M. Dorsey
Chapter 134: Sleep Disturbances Associated With Neuropsychiatric Disease (PDF)
Eric A. Nofzinger And Matcheri Keshavan
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