Neuropsychopharmacology Reviews: The Next Generation of Progress

A series editorial by Salvatore J. Enna, Ph.D.

This volume represents the inaugural issue of Neuropsychopharmacology Reviews. As an annual publication, the offering is designed to provide authoritative and timely coverage of contemporary topics in the field. As subscribers to Neuropsychopharmacology, members of the College have early access to these reports both on line and in print.

Neuropsychopharmacology Reviews replaces the Generation of Progress, which consisted of five volumes published intermittently between 1968 and 2002. While the Generation of Progress served for decades as a major reference work, a single large volume is an increasingly difficult mechanism for promulgating new data given the pace of research, developments in information technology, and the time needed for authoring, editing, printing, and distributing such a massive work. After considering several alternatives, it was decided that a yearly publication of review articles is more easily managed, and makes possible more timely coverage of critical topics than is possible with a major reference work. Timely because the reviews are written shortly before the publication, and topical in that it will be possible to publish updates and perspectives on the same subject as often as warranted. To help ensure timeliness, the work includes a Hot Topics chapter that is prepared just prior to the production deadline. This section contains summaries of some of the most recent developments in the field. The volume also features downloadable graphics that can be used as a teaching resource. It is anticipated that the regular publication of this high-quality review journal will build a recognizable franchise, further establishing the College as the most authoritative source for information in the discipline.

  • Volume Four - Cognition

    Editorials

    Cognition: The Ultimate Brain Function

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    Trevor W. Robbins

    Reviews

    Neuroanatomical and Neurochemical Substrates of Timing

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    How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

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    Modes and Models of Forebrain Cholinergic Neuromodulation of Cognition

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    Opponency Revisited: Competition and Cooperation Between Dopamine and Serotonin

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    Serotonin and Dopamine: Unifying Affective, Activational, and Decision Functions

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    The Roles of Dopamine and Serotonin in Decision Making: Evidence from Pharmacological Experiments in Humans

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    Neurogenetics and Pharmacology of Learning, Motivation, and Cognition

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    Affective Cognition and its Disruption in Mood Disorders

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    Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response

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    Understanding the Effects of Stimulant Medications on Cognition in Individuals with Attention-Deficit Hyperactivity Disorder: A Decade of Progress

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    Pharmacological Enhancement of Memory and Executive Functioning in Laboratory Animals

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    Update on Memory Systems and Processes

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    Glutamate Receptors in Extinction and Extinction-Based Therapies for Psychiatric Illness

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    Glutamatergic Model Psychoses: Prediction Error, Learning, and Inference

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    Glutamatergic Model Psychoses: Prediction Error, Learning, and Inference

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    Cognitive Control Deficits in Schizophrenia: Mechanisms and Meaning

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    How Placebos Change the Patient's Brain

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    Hot Topics

    Neurocognitive Dimensions of Breast Cancer and Its Treatment

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    NICO-TEEN: Neural Substrates that Mediate Adolescent Tobacco Abuse

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    Epigenetic Modifications in Neurons are Essential for Formation and Storage of Behavioral Memory

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    Emerging Roles for Ectonucleotidases in Pain-Sensing Neurons

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    Gambling Rats: Insight into Impulsive and Addictive Behavior

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    Insulin Regulation of Monoamine Signaling: Pathway to Obesity

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    Extinction Learning and Adult Neurogenesis

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    Transcriptional Control of Serotonin-Modulated Behavior and Physiology

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    An Emerging Role for TARPs in Neuropsychiatric Disorders

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    New Horizons for Selective 5-HT2C Receptor Ligands in Psychiatric/Neurological Disorders

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    Modeling Neuropsychiatric Disease-Relevant Human SNPs in Mice

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    Cortical Circuits for Motor Control

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    Oral Methylphenidate Normalizes Cingulate Activity and Decreases Impulsivity in Cocaine Addiction During an Emotionally Salient Cognitive Task

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    Failures in Learning-Dependent Predictive Perception as the Key Cognitive Vulnerability to Psychosis in Schizophrenia

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    New Insights into the Mechanisms Underlying the Effects of BDNF on Eating Behavior

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    The Therapeutic Potential of κ-Opioids for Treatment of Pain and Addiction

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    New Treatments in Amyotrophic Lateral Sclerosis

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    fMRI Studies of Reward Processing in Adolescent Depression

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    Dorsal vs Ventral Hippocampal Neurogenesis: Implications for Cognition and Mood

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  • Volume Five - Neurotherapeutics

    Editorials

    Neurotherapeutics

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    Gwenn S Smith, Xiaohua Li and P Jeffrey Conn

    Reviews

    From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

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    Muscarinic and Nicotinic Acetylcholine Receptor Agonists and Allosteric Modulators for the Treatment of Schizophrenia

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    Cognitive Training for Impaired Neural Systems in Neuropsychiatric Illness

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    Review of Pharmacological Treatment in Mood Disorders and Future Directions for Drug Development

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    Somatic Treatments for Mood Disorders

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    Cognitive Mechanisms of Treatment in Depression

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    Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

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    Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

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    Therapeutic Strategies in Fragile X Syndrome: Dysregulated mGluR Signaling and Beyond

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    Networking in Autism: Leveraging Genetic, Biomarker and Model System Findings in the Search for New Treatments

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    Parkinson's Disease Therapeutics: New Developments and Challenges Since the Introduction of Levodopa

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    Epigenetic Treatments for Cognitive Impairments

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    Alzheimer's Therapeutics: Translation of Preclinical Science to Clinical Drug Development

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    Commentary

    New Era for Novel CNS Drug Development

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    Translating Discoveries into Medicine: Psychiatric Drug Development in 2011

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    NIA Commentary: Translational Issues in Alzheimer's Disease Drug Development

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    Neuroscience Networking: Linking Discovery to Drugs

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    New Medications for Substance Use Disorders: Challenges and Opportunities

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    The Role of Complementary, Alternative, and Integrative Medicine in Personalized Health Care

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    Hot Topics

    Grateful DREADDs: Engineered Receptors Reveal How Neural Circuits Regulate Behavior

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    Dopamine D3 Receptor Function and Cocaine Exposure

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    Chronic N-acetylcysteine after cocaine self-administration produces enduring reductions in drug-seeking

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    Methamphetamine-Induced Oxidation of Proteins and Alterations in Protein Processing

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    Placental Source for 5-HT that Tunes Fetal Brain Development

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    Mainstreaming Mice

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    Phospholipase D as a Therapeutic Target in Brain Disorders

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    Transferrin Antibodies Into the Brain

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    Endogenous Opioids as Physiological Antidepressants: Complementary Role of Delta Receptors and Dopamine

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    Oxytocin as a Potential Therapeutic Target for Schizophrenia and Other Neuropsychiatric Conditions

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    Dysregulation of mTOR Signaling in Neuropsychiatric Disorders: Therapeutic Implications

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    Habenular Signaling in Nicotine Reinforcement

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    Circuits, Cells, and Synapses: Toward a New Target for Deep Brain Stimulation in Depression

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    Update on Corticotropin-Releasing Factor Pharmacotherapy for Psychiatric Disorders: A Revisionist View

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    Update on Omega-3 Polyunsaturated Fatty Acids in Early-Stage Psychotic Disorders

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    Beyond Antipsychotics: Pharmacologically-Augmented Cognitive Therapies (PACTs) for Schizophrenia

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    From Father to Offspring: Paternal Transmission of Depressive-Like Behaviors

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    View the NPPR Nature website

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  • Volume Six - Epigenetics

    Editorials

    Epigenetic Mechanisms in Psychiatry

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    Schahram Akbarian and Eric J Nestler

    Reviews

    Histone Regulation in the CNS: Basic Principles of Epigenetic Plasticity

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    Ian Maze, Kyung-Min Noh and C David Allis

    DNA Methylation and Its Basic Function

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    Lisa D Moore, Thuc Le and Guoping Fan

    General Principals of miRNA Biogenesis and Regulation in the Brain

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    Dónal O'Carroll and Anne Schaefer

    Random and Non-Random Monoallelic Expression

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    Andrew Chess

    The Role of Histone Acetylation in Memory Formation and Cognitive Impairments

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    Lucia Peixoto and Ted Abel

    Epigenetic Mechanisms in Learned Fear: Implications for PTSD

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    Iva B Zovkic and J David Sweatt

    Hot Topics

    Estrogen and Leptin Regulation of Endocrinological Features of Anorexia Nervosa

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    Lynda M Brown and Deborah J Clegg

    Transcriptional Plasticity in the Brain following Metabolic Challenge

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    Douglas J Guarnieri and Ralph J DiLeone

    Neurobiological Correlates of the Familial Risk for Stimulant Drug Dependence

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    Karen D Ersche

    Epigenetic Regulation of Synapsin Genes in Mood Disorders

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    Cristiana Cruceanu, Erika Freemantle, Martin Alda, Guy A Rouleau and Gustavo Turecki

    Neuroinflammation and Autism: Toward Mechanisms and Treatments

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    Christopher J McDougle and William A Carlezon Jr

    Cognitive Training for Psychiatric Disorders

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    Karuna Subramaniam and Sophia Vinogradov

  • Volume Seven - Biomolecular Discovery

    Editorials

    Frontiers of Biomolecular Exploration in Brain Disorders

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    Carol L Nilsson and Kathryn A Cunningham

    Reviews

    Integrative Biological Analysis For Neuropsychopharmacology

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    Mark R Emmett, Roger A Kroes, Joseph R Moskal, Charles A Conrad, Waldemar Priebe, Fernanda Laezza, Anke Meyer-Baese and Carol L Nilsson

    Mass Spectrometry Strategies for Clinical Metabolomics and Lipidomics in Psychiatry, Neurology, and Neuro-Oncology

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    Paul L Wood

    Mass Spectrometry Imaging, an Emerging Technology in Neuropsychopharmacology

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    Mohammadreza Shariatgorji, Per Svenningsson and Per E Andrén

    Small-Volume Analysis of Cell–Cell Signaling Molecules in the Brain

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    Elena V Romanova, Jordan T Aerts, Callie A Croushore and Jonathan V Sweedler

    Postmortem Brain: An Underutilized Substrate for Studying Severe Mental Illness

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    Robert E McCullumsmith, John H Hammond, Dan Shan and James H Meador-Woodruff

    Hot Topics

    Neurobiology of Rapid Acting Antidepressants: Role of BDNF and GSK-3β

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    Ronald S Duman and George K Aghajanian

    Seeing the Future: Epigenetic Biomarkers of Postpartum Depression

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    Zachary Kaminsky and Jennifer Payne

    Cell Adhesion Molecules: Druggable Targets for Modulating the Connectome and Brain Disorders?

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    George R Uhl and Jana Drgonova

    Circuits in Sync: Decoding Theta Communication in Fear and Safety

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    Ekaterina Likhtik and Joshua A Gordon

  • Volume Eight - Neurodevelopment and the Origins of Brain Disorders

    Editorials

    Neurodevelopment and the Origins of Brain Disorders

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    Reviews

    Synapse Assembly and Neurodevelopmental Disorders

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    Philip Washbourne

    Development of Cortical Interneurons

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    Jianhua Chu and Stewart A Anderson

    Developmental Perspectives on Oxytocin and Vasopressin

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    Elizabeth A D Hammock

    Child Psychiatry Branch of the National Institute of Mental Health Longitudinal Structural Magnetic Resonance Imaging Study of Human Brain Development

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    Jay N Giedd, Armin Raznahan, Aaron Alexander-Bloch, Eric Schmitt, Nitin Gogtay and Judith L Rapoport

    Sensitive Periods in Affective Development: Nonlinear Maturation of Fear Learning

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    Catherine A Hartley and Francis S Lee

    Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

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    Emily J Ross, Devon L Graham, Kelli M Money and Gregg D Stanwood

    Hot Topics

    In vivo Calcium Imaging to Illuminate Neurocircuit Activity Dynamics Underlying Naturalistic Behavior

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    Shanna L Resendez and Garret D Stuber

    DREAMM: A Biobehavioral Imaging Methodology for Dynamic In Vivo Whole-Brain Mapping of Cell Type-Specific Functional Networks

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    Michael Michaelides and Yasmin L Hurd

    More than a Gut Feeling: the Microbiota Regulates Neurodevelopment and Behavior

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    John F Cryan and Timothy G Dinan

    Memory Allocation

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    Paul W Frankland and Sheena A Josselyn

    Oxytocin, Social Cognition and Psychiatry

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    Larry J Young

    FKBP5 Allele-Specific Epigenetic Modification in Gene by Environment Interaction

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    Torsten Klengel and Elisabeth B Binder

  • Volume Nine - Impact of Stress on the Brain: Pathology, Treatment and Prevention

    Editorials

    Impact of Stress on the Brain: Pathology, Treatment and Prevention

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    Kerry J Ressler and Jordan W Smoller

    Reviews

    Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex

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    Bruce S McEwen, Carla Nasca and Jason D Gray

    Adult Hippocampal Neurogenesis, Fear Generalization, and Stress

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    Antoine Besnard and Amar Sahay

    Induction and Expression of Fear Sensitization Caused by Acute Traumatic Stress

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    Jennifer N Perusini, Edward M Meyer, Virginia A Long, Vinuta Rau, Nathaniel Nocera, Jacob Avershal, James Maksymetz, Igor Spigelman and Michael S Fanselow

    Stress and Fear Extinction

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    Stephen Maren and Andrew Holmes

    Neurobiological Interactions Between Stress and the Endocannabinoid System

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    Maria Morena, Sachin Patel, Jaideep S Bains and Matthew N Hill

    Stress Modulation of Opposing Circuits in the Bed Nucleus of the Stria Terminalis

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    Sarah E Daniel and Donald G Rainnie

    The Human BNST: Functional Role in Anxiety and Addiction

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    S N Avery, J A Clauss and J U Blackford

    Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress

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    W Thomas Boyce

    The Neuro-Environmental Loop of Plasticity: A Cross-Species Analysis of Parental Effects on Emotion Circuitry Development Following Typical and Adverse Caregiving

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    Bridget L Callaghan and Nim Tottenham

    Early Adverse Experiences and the Developing Brain

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    Johanna Bick and Charles A Nelson

    Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks

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    Yuncai Chen and Tallie Z Baram

    The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming

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    Stefanie L Bronson and Tracy L Bale

    Models of Intergenerational and Transgenerational Transmission of Risk for Psychopathology in Mice

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    Torsten Klengel, Brian G Dias and Kerry J Ressler

    Intergenerational Transmission of Stress in Humans

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    Mallory E Bowers and Rachel Yehuda

    Genetic Approaches to Hypothalamic-Pituitary-Adrenal Axis Regulation

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    Melinda G Arnett, Lisa M Muglia, Gloria Laryea and Louis J Muglia

    Gene–Stress–Epigenetic Regulation of FKBP5: Clinical and Translational Implications

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    Anthony S Zannas, Tobias Wiechmann, Nils C Gassen and Elisabeth B Binder

    Genetic Moderation of Stress Effects on Corticolimbic Circuitry

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    Ryan Bogdan, David Pagliaccio, David AA Baranger and Ahmad R Hariri

    The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders

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    Jordan W Smoller

    Neuroimaging of Fear-Associated Learning

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    John A Greco and Israel Liberzon

    Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress

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    John R Mantsch, David A Baker, Douglas Funk, Anh D Lê and Yavin Shaham

    Prevention of Trauma and Stressor-Related Disorders: A Review

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    Jonathon R Howlett and Murray B Stein

    Hot Topics

    Rehebbilitating Memory

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    Tomás J Ryan and Susumu Tonegawa

    Extracellular Vesicles: Goodies for the Brain?

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    Eva-Maria Krämer-Albers and Wen Ping Kuo-Elsner

    New Signaling Pathway for Gut–Brain Interactions

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    Vera Chesnokova and Robert N Pechnick

    Neural Basis of Mindfulness Interventions that Moderate the Impact of Stress on the Brain

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    Martin P Paulus

    Dynorphin, Dysphoria, and Dependence: the Stress of Addiction

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    Charles Chavkin and George F Koob

    RiboTag: Not Lost in Translation

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    Adam J Lesiak and John F Neumaier

    Pharmacological Treatments for Autism Spectrum Disorder: Will Emerging Approaches Yield New Treatments?

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    Rocco G Gogliotti and P Jeffrey Conn

    Nicotine-Targeting Nano-Vaccines for Smoking Cessation

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    Rajeev I Desai and Jack Bergman

    Neurochips Enable Nanoscale Devices for High-Resolution In Vivo Neurotransmitter Sensing

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    Nako Nakatsuka and Anne M Andrews

    Closing the Loop in Deep Brain Stimulation for Psychiatric Disorders: Lessons from Motor Neural Prosthetics

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    Alik S Widge and Amar Sahay

    Heteroreceptor Complexes and their Allosteric Receptor–Receptor Interactions as a Novel Biological Principle for Integration of Communication in the CNS: Targets for Drug Development

    External Link

    Kjell Fuxe and Dasiel O Borroto-Escuela

    Hippocampal Neurogenesis and Memory Clearance

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    Paul W Frankland and Sheena A Josselyn

    Translational Studies of Sex Differences in Sensitivity to Opioid Addiction

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    Elena H Chartoff and R Kathryn McHugh

    Hormone modulation improves cognition in schizophrenia

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    Cynthia Shannon Weickert and Thomas W Weickert

    Neurobiology of Compulsive Sexual Behavior: Emerging Science

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    Shane W Kraus, Valerie Voon and Marc N Potenza

    Somatic DNA Variation in Brain as a Source of Risk for CNS Diseases

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    Glenn A Doyle and Wade H Berrettini

    Psychiatric Illnesses as Oscillatory Connectomopathies

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    Sophia Vinogradov and Alexander Herman

    The Cellular Sequelae of Early Stress: Focus on Aging and Mitochondria

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    Kathryn K Ridout, Linda L Carpenter and Audrey R Tyrka

  • Volume Ten - The Immunology of Behavior—Exploring the Role of the Immune System in Brain Health and Illness

    Editorials

    The Immunology of Behavior—Exploring the Role of the Immune System in Brain Health and Illness

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    Andrew H Miller, Ebrahim Haroon and Jennifer C Felger

    Reviews

    Pathogen–Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance

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    Charles L Raison and Andrew H Miller

    Central Nervous System: (Immunological) Ivory Tower or Not?

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    Ioana A Marin and Jonathan Kipnis

    Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

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    Monika Fleshner, Matthew Frank and Steven F Maier

    Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal

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    Michael D Weber, Jonathan P Godbout and John F Sheridan

    Immune and Neuroendocrine Mechanisms of Stress Vulnerability and Resilience

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    Caroline Ménard, Madeline L Pfau, Georgia E Hodes and Scott J Russo

    Genetic Contributions of Inflammation to Depression

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    Jacob Barnes, Valeria Mondelli and Carmine M Pariante

    Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?

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    Andrea Danese and Stephanie J Lewis

    Role of Adiposity-Driven Inflammation in Depressive Morbidity

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    Lucile Capuron, Julie Lasselin and Nathalie Castanon

    Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity

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    Michael R Irwin and Mark R Opp

    Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse

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    Michael J Lacagnina, Phillip D Rivera and Staci D Bilbo

    Microbes, Immunity, and Behavior: Psychoneuroimmunology Meets the Microbiome

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    Timothy G Dinan and John F Cryan

    Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders

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    Ebrahim Haroon, Andrew H Miller and Gerard Sanacora

    Inflammation Effects on Motivation and Motor Activity: Role of Dopamine

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    Jennifer C Felger and Michael T Treadway

    In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior

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    Naomi I Eisenberger, Mona Moieni, Tristen K Inagaki, Keely A Muscatell and Michael R Irwin

    Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond

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    Vasiliki Michopoulos, Abigail Powers, Charles F Gillespie, Kerry J Ressler and Tanja Jovanovic

    Role of Inflammation in Suicide: From Mechanisms to Treatment

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    Lena Brundin, Elena Y Bryleva and Keerthi Thirtamara Rajamani

    The Role of the Immune System in Autism Spectrum Disorder

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    Amory Meltzer and Judy Van de Water

    Towards an Immunophenotype of Schizophrenia: Progress, Potential Mechanisms, and Future Directions

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    Brian J Miller and David R Goldsmith

    Microglia Priming with Aging and Stress

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    Anzela Niraula, John F Sheridan and Jonathan P Godbout

    Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation

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    Andrew H Miller, Ebrahim Haroon and Jennifer C Felger

    Hot Topics

    Dissecting Suicidality Using a Combined Genomic and Clinical Approach

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    Alexander B Niculescu and Helen Le-Niculescu

    Food Addiction and Obesity

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    Carrie R Ferrario

    The Emerging Role of Innate Immunity in Alzheimer’s Disease

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    Deepak Kumar Vijaya Kumar and Robert D Moir

    Pramipexole in Treatment Resistant-Depression, Possible Role of Inflammatory Cytokines

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    Rodrigo Escalona and Jan Fawcett

    Modeling the Impact of Social Contact on Substance Use

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    Mark A Smith and Justin C Strickland

    Impact on Cortical Function of Cocaine Abuse Co-Occurring with HIV

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    T Celeste Napier

    Mirror Neurons in Psychiatric Disorders: from Neuroception to Bio-behavioral System Dysregulation

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    Amedeo Minichino and Kristin Cadenhead

    The Cannabinoid Receptor 1 as a Key Mediator of Adolescent Behavior

    External Link

    Rainer Spanagel and Falk Kiefer

    Prospects for Medications to Reverse Causative Epigenetic Processes in Neuropsychiatry Disorders

    External Link

    Moshe Szyf

    Ketamine Mechanism of Action: Separating the Wheat from the Chaff

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    Todd D Gould, Panos Zanos and Carlos A Zarate Jr

    The Direct and Indirect Pathways of the Nucleus Accumbens are not What You Think

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    Yonatan M Kupchik and Peter W Kalivas

    Therapeutic Potential of Conjugated siRNAs for the Treatment of Major Depressive Disorder

    External Link

    Francesc Artigas and Analia Bortolozzi

    Error Processing in Depressive States: A Translational Opportunity?

    External Link

    Diego A Pizzagalli and William A Carlezon

    Imaging Adult Hippocampal Neurogenesis In Vivo

    External Link

    Jeremy S Biane and Mazen A Kheirbek

    Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets

    External Link

    Claes Wahlestedt

    REM Sleep on It!

    External Link

    Richard Boyce and Antoine Adamantidis

    The Neuroimmune Basis of Excessive Alcohol Consumption

    External Link

    Jody Mayfield and R Adron Harris

    Oxytocin-Augmented Psychotherapy: Beware of Context

    External Link

    René Hurlemann

    A Self-Generated Environmental Factor as a Potential Contributor to Atypical Early Social Communication in Autism

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    Takefumi Kikusui and Noboru Hiroi

  • Volume Eleven - Cannabis and Cannabinoids: From Synapse to Society

    Editorials

    Cannabis and Cannabinoids: From Synapse to Society

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    Margaret Haney and Matthew N Hill

    Reviews

    CB1 Receptor Signaling in the Brain: Extracting Specificity from Ubiquity

    External Link

    Arnau Busquets-Garcia, Jaideep Bains and Giovanni Marsicano

    The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development

    External Link

    Heidi C Meyer, Francis S Lee and Dylan G Gee

    Sex-Dependent Effects of Cannabis and Cannabinoids: A Translational Perspective

    External Link

    Ziva D Cooper and Rebecca M Craft

    The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain

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    Giulia Donvito, Sara R Nass, Jenny L Wilkerson, Zachary A Curry, Lesley D Schurman, Steven G Kinsey and Aron H Lichtman

    Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder

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    Matthew N Hill, Patrizia Campolongo, Rachel Yehuda and Sachin Patel

    Endocannabinoid Regulation of Reward and Reinforcement through Interaction with Dopamine and Endogenous Opioid Signaling

    External Link

    J M Wenzel and J F Cheer

    Preclinical Studies of Cannabinoid Reward, Treatments for Cannabis Use Disorder, and Addiction-Related Effects of Cannabinoid Exposure

    External Link

    Leigh V Panlilio and Zuzana Justinova

    Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol

    External Link

    Douglas L Boggs, Jacques D Nguyen, Daralyn Morgenson, Michael A Taffe and Mohini Ranganathan

    Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?

    External Link

    Cecilia J Hillard

    The Current State of Pharmacological Treatments for Cannabis Use Disorder and Withdrawal

    External Link

    Christina A Brezing and Frances R Levin

    US Epidemiology of Cannabis Use and Associated Problems

    External Link

    Deborah S Hasin

    Hot Topics

    Toward a Translationally Relevant Preclinical Model of Cannabis Use

    External Link

    Ryan J McLaughlin

    Setting the Legal Age for Access to Cannabis in Canada: Bridging Neuroscience, Policy, and Prevention

    External Link

    Rebecca J Haines-Saah and Emily K Jenkins

    Medical Cannabis Research: Issues and Priorities

    External Link

    Mark A Ware

    Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain

    External Link

    Val J Watts

    Novel Synthetic Opioids and Overdose Deaths: Tip of the Iceberg?

    External Link

    Michael H Baumann and Gavril W Pasternak

    Opioidergic regulation of pain and pleasure in human social relationships

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    Lauri Nummenmaa and Tomi Karjalainen

    Modulating Amygdala–Hippocampal Network Communication: A Potential Therapy for Neuropsychiatric Disorders

    External Link

    Jie Zheng and Jack J Lin

    Modeling Non-Syndromic Autism with Human-Induced Pluripotent Stem Cells

    External Link

    Luke AD Bury and Anthony Wynshaw-Boris

    Innovative Therapeutic Intervention For Opioid Use Disorder

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    F Gerard Moeller and Kathryn A Cunningham

    The Ketamine Metabolite 2R,6R-Hydroxynorketamine Blocks NMDA Receptors and Impacts Downstream Signaling Linked to Antidepressant Effects

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    Ege T Kavalali and Lisa M Monteggia

    Cognitive Signaling in Cerebellar Granule Cells

    External Link

    Mark J Wagner

    The Promise of Genome Editing for Modeling Psychiatric Disorders

    External Link

    Stephanie PB Caligiuri and Paul J Kenny

    Aggression Addiction and Relapse: A New Frontier in Psychiatry

    External Link

    Sam A Golden and Yavin Shaham

    Computational Approaches to Behavior Analysis in Psychiatry

    External Link

    Cheryl M Corcoran and Guillermo A Cecchi

    Cannabinoid Receptor 1 Positive Allosteric Modulators for Posttraumatic Stress Disorder

    External Link

    Anantha Shekhar and Ganesh A Thakur

    Integrating ‘Omics’ Approaches to Prioritize New Pathogenetic Mechanisms for Mental Disorders

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    Annamaria Cattaneo and Carmine M Pariante

    A Translational Model to Assess Sign-Tracking and Goal-Tracking Behavior in Children

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    Michelle A Joyner, Ashley N Gearhardt and Shelly B Flagel

    The Role of Mitochondrial Glutamate Metabolism in Cognitive Development and Disease

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    Ozan Baytaş and Eric M Morrow

    Cross-Species Neurophysiological Biomarkers of Attentional Dysfunction in Schizophrenia: Bridging the Translational Gap

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    Jared W Young and Gregory A Light