Neuropsychopharmacology Reviews: The Next Generation of Progress

A series editorial by Salvatore J. Enna, Ph.D.

This volume represents the inaugural issue of Neuropsychopharmacology Reviews. As an annual publication, the offering is designed to provide authoritative and timely coverage of contemporary topics in the field. As subscribers to Neuropsychopharmacology, members of the College have early access to these reports both on line and in print.

Neuropsychopharmacology Reviews replaces the Generation of Progress, which consisted of five volumes published intermittently between 1968 and 2002. While the Generation of Progress served for decades as a major reference work, a single large volume is an increasingly difficult mechanism for promulgating new data given the pace of research, developments in information technology, and the time needed for authoring, editing, printing, and distributing such a massive work. After considering several alternatives, it was decided that a yearly publication of review articles is more easily managed, and makes possible more timely coverage of critical topics than is possible with a major reference work. Timely because the reviews are written shortly before the publication, and topical in that it will be possible to publish updates and perspectives on the same subject as often as warranted. To help ensure timeliness, the work includes a Hot Topics chapter that is prepared just prior to the production deadline. This section contains summaries of some of the most recent developments in the field. The volume also features downloadable graphics that can be used as a teaching resource. It is anticipated that the regular publication of this high-quality review journal will build a recognizable franchise, further establishing the College as the most authoritative source for information in the discipline.

  • Volume Four - Cognition

    Editorials

    Cognition: The Ultimate Brain Function

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    Trevor W. Robbins

    Reviews

    Neuroanatomical and Neurochemical Substrates of Timing

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    How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

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    Modes and Models of Forebrain Cholinergic Neuromodulation of Cognition

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    Opponency Revisited: Competition and Cooperation Between Dopamine and Serotonin

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    Serotonin and Dopamine: Unifying Affective, Activational, and Decision Functions

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    The Roles of Dopamine and Serotonin in Decision Making: Evidence from Pharmacological Experiments in Humans

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    Neurogenetics and Pharmacology of Learning, Motivation, and Cognition

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    Affective Cognition and its Disruption in Mood Disorders

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    Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response

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    Understanding the Effects of Stimulant Medications on Cognition in Individuals with Attention-Deficit Hyperactivity Disorder: A Decade of Progress

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    Pharmacological Enhancement of Memory and Executive Functioning in Laboratory Animals

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    Update on Memory Systems and Processes

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    Glutamate Receptors in Extinction and Extinction-Based Therapies for Psychiatric Illness

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    Glutamatergic Model Psychoses: Prediction Error, Learning, and Inference

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    Glutamatergic Model Psychoses: Prediction Error, Learning, and Inference

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    Cognitive Control Deficits in Schizophrenia: Mechanisms and Meaning

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    How Placebos Change the Patient's Brain

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    Hot Topics

    Neurocognitive Dimensions of Breast Cancer and Its Treatment

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    NICO-TEEN: Neural Substrates that Mediate Adolescent Tobacco Abuse

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    Epigenetic Modifications in Neurons are Essential for Formation and Storage of Behavioral Memory

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    Emerging Roles for Ectonucleotidases in Pain-Sensing Neurons

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    Gambling Rats: Insight into Impulsive and Addictive Behavior

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    Insulin Regulation of Monoamine Signaling: Pathway to Obesity

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    Extinction Learning and Adult Neurogenesis

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    Transcriptional Control of Serotonin-Modulated Behavior and Physiology

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    An Emerging Role for TARPs in Neuropsychiatric Disorders

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    New Horizons for Selective 5-HT2C Receptor Ligands in Psychiatric/Neurological Disorders

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    Modeling Neuropsychiatric Disease-Relevant Human SNPs in Mice

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    Cortical Circuits for Motor Control

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    Oral Methylphenidate Normalizes Cingulate Activity and Decreases Impulsivity in Cocaine Addiction During an Emotionally Salient Cognitive Task

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    Failures in Learning-Dependent Predictive Perception as the Key Cognitive Vulnerability to Psychosis in Schizophrenia

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    New Insights into the Mechanisms Underlying the Effects of BDNF on Eating Behavior

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    The Therapeutic Potential of κ-Opioids for Treatment of Pain and Addiction

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    New Treatments in Amyotrophic Lateral Sclerosis

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    fMRI Studies of Reward Processing in Adolescent Depression

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    Dorsal vs Ventral Hippocampal Neurogenesis: Implications for Cognition and Mood

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  • Volume Five - Neurotherapeutics

    Editorials

    Neurotherapeutics

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    Gwenn S Smith, Xiaohua Li and P Jeffrey Conn

    Reviews

    From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

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    Muscarinic and Nicotinic Acetylcholine Receptor Agonists and Allosteric Modulators for the Treatment of Schizophrenia

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    Cognitive Training for Impaired Neural Systems in Neuropsychiatric Illness

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    Review of Pharmacological Treatment in Mood Disorders and Future Directions for Drug Development

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    Somatic Treatments for Mood Disorders

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    Cognitive Mechanisms of Treatment in Depression

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    Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

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    Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

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    Therapeutic Strategies in Fragile X Syndrome: Dysregulated mGluR Signaling and Beyond

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    Networking in Autism: Leveraging Genetic, Biomarker and Model System Findings in the Search for New Treatments

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    Parkinson's Disease Therapeutics: New Developments and Challenges Since the Introduction of Levodopa

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    Epigenetic Treatments for Cognitive Impairments

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    Alzheimer's Therapeutics: Translation of Preclinical Science to Clinical Drug Development

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    Commentary

    New Era for Novel CNS Drug Development

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    Translating Discoveries into Medicine: Psychiatric Drug Development in 2011

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    NIA Commentary: Translational Issues in Alzheimer's Disease Drug Development

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    Neuroscience Networking: Linking Discovery to Drugs

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    New Medications for Substance Use Disorders: Challenges and Opportunities

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    The Role of Complementary, Alternative, and Integrative Medicine in Personalized Health Care

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    Hot Topics

    Grateful DREADDs: Engineered Receptors Reveal How Neural Circuits Regulate Behavior

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    Dopamine D3 Receptor Function and Cocaine Exposure

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    Chronic N-acetylcysteine after cocaine self-administration produces enduring reductions in drug-seeking

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    Methamphetamine-Induced Oxidation of Proteins and Alterations in Protein Processing

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    Placental Source for 5-HT that Tunes Fetal Brain Development

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    Mainstreaming Mice

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    Phospholipase D as a Therapeutic Target in Brain Disorders

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    Transferrin Antibodies Into the Brain

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    Endogenous Opioids as Physiological Antidepressants: Complementary Role of Delta Receptors and Dopamine

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    Oxytocin as a Potential Therapeutic Target for Schizophrenia and Other Neuropsychiatric Conditions

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    Dysregulation of mTOR Signaling in Neuropsychiatric Disorders: Therapeutic Implications

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    Habenular Signaling in Nicotine Reinforcement

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    Circuits, Cells, and Synapses: Toward a New Target for Deep Brain Stimulation in Depression

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    Update on Corticotropin-Releasing Factor Pharmacotherapy for Psychiatric Disorders: A Revisionist View

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    Update on Omega-3 Polyunsaturated Fatty Acids in Early-Stage Psychotic Disorders

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    Beyond Antipsychotics: Pharmacologically-Augmented Cognitive Therapies (PACTs) for Schizophrenia

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    From Father to Offspring: Paternal Transmission of Depressive-Like Behaviors

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    View the NPPR Nature website

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  • Volume Six - Epigenetics

    Editorials

    Epigenetic Mechanisms in Psychiatry

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    Schahram Akbarian and Eric J Nestler

    Reviews

    Histone Regulation in the CNS: Basic Principles of Epigenetic Plasticity

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    Ian Maze, Kyung-Min Noh and C David Allis

    DNA Methylation and Its Basic Function

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    Lisa D Moore, Thuc Le and Guoping Fan

    General Principals of miRNA Biogenesis and Regulation in the Brain

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    Dónal O'Carroll and Anne Schaefer

    Random and Non-Random Monoallelic Expression

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    Andrew Chess

    The Role of Histone Acetylation in Memory Formation and Cognitive Impairments

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    Lucia Peixoto and Ted Abel

    Epigenetic Mechanisms in Learned Fear: Implications for PTSD

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    Iva B Zovkic and J David Sweatt

    Hot Topics

    Estrogen and Leptin Regulation of Endocrinological Features of Anorexia Nervosa

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    Lynda M Brown and Deborah J Clegg

    Transcriptional Plasticity in the Brain following Metabolic Challenge

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    Douglas J Guarnieri and Ralph J DiLeone

    Neurobiological Correlates of the Familial Risk for Stimulant Drug Dependence

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    Karen D Ersche

    Epigenetic Regulation of Synapsin Genes in Mood Disorders

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    Cristiana Cruceanu, Erika Freemantle, Martin Alda, Guy A Rouleau and Gustavo Turecki

    Neuroinflammation and Autism: Toward Mechanisms and Treatments

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    Christopher J McDougle and William A Carlezon Jr

    Cognitive Training for Psychiatric Disorders

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    Karuna Subramaniam and Sophia Vinogradov

  • Volume Seven - Biomolecular Discovery

    Editorials

    Frontiers of Biomolecular Exploration in Brain Disorders

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    Carol L Nilsson and Kathryn A Cunningham

    Reviews

    Integrative Biological Analysis For Neuropsychopharmacology

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    Mark R Emmett, Roger A Kroes, Joseph R Moskal, Charles A Conrad, Waldemar Priebe, Fernanda Laezza, Anke Meyer-Baese and Carol L Nilsson

    Mass Spectrometry Strategies for Clinical Metabolomics and Lipidomics in Psychiatry, Neurology, and Neuro-Oncology

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    Paul L Wood

    Mass Spectrometry Imaging, an Emerging Technology in Neuropsychopharmacology

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    Mohammadreza Shariatgorji, Per Svenningsson and Per E Andrén

    Small-Volume Analysis of Cell–Cell Signaling Molecules in the Brain

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    Elena V Romanova, Jordan T Aerts, Callie A Croushore and Jonathan V Sweedler

    Postmortem Brain: An Underutilized Substrate for Studying Severe Mental Illness

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    Robert E McCullumsmith, John H Hammond, Dan Shan and James H Meador-Woodruff

    Hot Topics

    Neurobiology of Rapid Acting Antidepressants: Role of BDNF and GSK-3β

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    Ronald S Duman and George K Aghajanian

    Seeing the Future: Epigenetic Biomarkers of Postpartum Depression

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    Zachary Kaminsky and Jennifer Payne

    Cell Adhesion Molecules: Druggable Targets for Modulating the Connectome and Brain Disorders?

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    George R Uhl and Jana Drgonova

    Circuits in Sync: Decoding Theta Communication in Fear and Safety

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    Ekaterina Likhtik and Joshua A Gordon

  • Volume Eight - Neurodevelopment and the Origins of Brain Disorders

    Editorials

    Neurodevelopment and the Origins of Brain Disorders

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    Reviews

    Synapse Assembly and Neurodevelopmental Disorders

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    Philip Washbourne

    Development of Cortical Interneurons

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    Jianhua Chu and Stewart A Anderson

    Developmental Perspectives on Oxytocin and Vasopressin

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    Elizabeth A D Hammock

    Child Psychiatry Branch of the National Institute of Mental Health Longitudinal Structural Magnetic Resonance Imaging Study of Human Brain Development

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    Jay N Giedd, Armin Raznahan, Aaron Alexander-Bloch, Eric Schmitt, Nitin Gogtay and Judith L Rapoport

    Sensitive Periods in Affective Development: Nonlinear Maturation of Fear Learning

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    Catherine A Hartley and Francis S Lee

    Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

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    Emily J Ross, Devon L Graham, Kelli M Money and Gregg D Stanwood

    Hot Topics

    In vivo Calcium Imaging to Illuminate Neurocircuit Activity Dynamics Underlying Naturalistic Behavior

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    Shanna L Resendez and Garret D Stuber

    DREAMM: A Biobehavioral Imaging Methodology for Dynamic In Vivo Whole-Brain Mapping of Cell Type-Specific Functional Networks

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    Michael Michaelides and Yasmin L Hurd

    More than a Gut Feeling: the Microbiota Regulates Neurodevelopment and Behavior

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    John F Cryan and Timothy G Dinan

    Memory Allocation

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    Paul W Frankland and Sheena A Josselyn

    Oxytocin, Social Cognition and Psychiatry

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    Larry J Young

    FKBP5 Allele-Specific Epigenetic Modification in Gene by Environment Interaction

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    Torsten Klengel and Elisabeth B Binder

  • Volume Nine - Impact of Stress on the Brain: Pathology, Treatment and Prevention

    Editorials

    Impact of Stress on the Brain: Pathology, Treatment and Prevention

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    Kerry J Ressler and Jordan W Smoller

    Reviews

    Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex

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    Bruce S McEwen, Carla Nasca and Jason D Gray

    Adult Hippocampal Neurogenesis, Fear Generalization, and Stress

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    Antoine Besnard and Amar Sahay

    Induction and Expression of Fear Sensitization Caused by Acute Traumatic Stress

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    Jennifer N Perusini, Edward M Meyer, Virginia A Long, Vinuta Rau, Nathaniel Nocera, Jacob Avershal, James Maksymetz, Igor Spigelman and Michael S Fanselow

    Stress and Fear Extinction

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    Stephen Maren and Andrew Holmes

    Neurobiological Interactions Between Stress and the Endocannabinoid System

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    Maria Morena, Sachin Patel, Jaideep S Bains and Matthew N Hill

    Stress Modulation of Opposing Circuits in the Bed Nucleus of the Stria Terminalis

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    Sarah E Daniel and Donald G Rainnie

    The Human BNST: Functional Role in Anxiety and Addiction

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    S N Avery, J A Clauss and J U Blackford

    Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress

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    W Thomas Boyce

    The Neuro-Environmental Loop of Plasticity: A Cross-Species Analysis of Parental Effects on Emotion Circuitry Development Following Typical and Adverse Caregiving

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    Bridget L Callaghan and Nim Tottenham

    Early Adverse Experiences and the Developing Brain

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    Johanna Bick and Charles A Nelson

    Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks

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    Yuncai Chen and Tallie Z Baram

    The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming

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    Stefanie L Bronson and Tracy L Bale

    Models of Intergenerational and Transgenerational Transmission of Risk for Psychopathology in Mice

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    Torsten Klengel, Brian G Dias and Kerry J Ressler

    Intergenerational Transmission of Stress in Humans

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    Mallory E Bowers and Rachel Yehuda

    Genetic Approaches to Hypothalamic-Pituitary-Adrenal Axis Regulation

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    Melinda G Arnett, Lisa M Muglia, Gloria Laryea and Louis J Muglia

    Gene–Stress–Epigenetic Regulation of FKBP5: Clinical and Translational Implications

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    Anthony S Zannas, Tobias Wiechmann, Nils C Gassen and Elisabeth B Binder

    Genetic Moderation of Stress Effects on Corticolimbic Circuitry

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    Ryan Bogdan, David Pagliaccio, David AA Baranger and Ahmad R Hariri

    The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders

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    Jordan W Smoller

    Neuroimaging of Fear-Associated Learning

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    John A Greco and Israel Liberzon

    Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress

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    John R Mantsch, David A Baker, Douglas Funk, Anh D Lê and Yavin Shaham

    Prevention of Trauma and Stressor-Related Disorders: A Review

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    Jonathon R Howlett and Murray B Stein

    Hot Topics

    Rehebbilitating Memory

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    Tomás J Ryan and Susumu Tonegawa

    Extracellular Vesicles: Goodies for the Brain?

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    Eva-Maria Krämer-Albers and Wen Ping Kuo-Elsner

    New Signaling Pathway for Gut–Brain Interactions

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    Vera Chesnokova and Robert N Pechnick

    Neural Basis of Mindfulness Interventions that Moderate the Impact of Stress on the Brain

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    Martin P Paulus

    Dynorphin, Dysphoria, and Dependence: the Stress of Addiction

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    Charles Chavkin and George F Koob

    RiboTag: Not Lost in Translation

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    Adam J Lesiak and John F Neumaier

    Pharmacological Treatments for Autism Spectrum Disorder: Will Emerging Approaches Yield New Treatments?

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    Rocco G Gogliotti and P Jeffrey Conn

    Nicotine-Targeting Nano-Vaccines for Smoking Cessation

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    Rajeev I Desai and Jack Bergman

    Neurochips Enable Nanoscale Devices for High-Resolution In Vivo Neurotransmitter Sensing

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    Nako Nakatsuka and Anne M Andrews

    Closing the Loop in Deep Brain Stimulation for Psychiatric Disorders: Lessons from Motor Neural Prosthetics

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    Alik S Widge and Amar Sahay

    Heteroreceptor Complexes and their Allosteric Receptor–Receptor Interactions as a Novel Biological Principle for Integration of Communication in the CNS: Targets for Drug Development

    External Link

    Kjell Fuxe and Dasiel O Borroto-Escuela

    Hippocampal Neurogenesis and Memory Clearance

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    Paul W Frankland and Sheena A Josselyn

    Translational Studies of Sex Differences in Sensitivity to Opioid Addiction

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    Elena H Chartoff and R Kathryn McHugh

    Hormone modulation improves cognition in schizophrenia

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    Cynthia Shannon Weickert and Thomas W Weickert

    Neurobiology of Compulsive Sexual Behavior: Emerging Science

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    Shane W Kraus, Valerie Voon and Marc N Potenza

    Somatic DNA Variation in Brain as a Source of Risk for CNS Diseases

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    Glenn A Doyle and Wade H Berrettini

    Psychiatric Illnesses as Oscillatory Connectomopathies

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    Sophia Vinogradov and Alexander Herman

    The Cellular Sequelae of Early Stress: Focus on Aging and Mitochondria

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    Kathryn K Ridout, Linda L Carpenter and Audrey R Tyrka

  • Volume Ten - The Immunology of Behavior—Exploring the Role of the Immune System in Brain Health and Illness

    Editorials

    The Immunology of Behavior—Exploring the Role of the Immune System in Brain Health and Illness

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    Andrew H Miller, Ebrahim Haroon and Jennifer C Felger

    Reviews

    Pathogen–Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance

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    Charles L Raison and Andrew H Miller

    Central Nervous System: (Immunological) Ivory Tower or Not?

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    Ioana A Marin and Jonathan Kipnis

    Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

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    Monika Fleshner, Matthew Frank and Steven F Maier

    Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal

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    Michael D Weber, Jonathan P Godbout and John F Sheridan

    Immune and Neuroendocrine Mechanisms of Stress Vulnerability and Resilience

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    Caroline Ménard, Madeline L Pfau, Georgia E Hodes and Scott J Russo

    Genetic Contributions of Inflammation to Depression

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    Jacob Barnes, Valeria Mondelli and Carmine M Pariante

    Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?

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    Andrea Danese and Stephanie J Lewis

    Role of Adiposity-Driven Inflammation in Depressive Morbidity

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    Lucile Capuron, Julie Lasselin and Nathalie Castanon

    Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity

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    Michael R Irwin and Mark R Opp

    Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse

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    Michael J Lacagnina, Phillip D Rivera and Staci D Bilbo

    Microbes, Immunity, and Behavior: Psychoneuroimmunology Meets the Microbiome

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    Timothy G Dinan and John F Cryan

    Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders

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    Ebrahim Haroon, Andrew H Miller and Gerard Sanacora

    Inflammation Effects on Motivation and Motor Activity: Role of Dopamine

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    Jennifer C Felger and Michael T Treadway

    In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior

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    Naomi I Eisenberger, Mona Moieni, Tristen K Inagaki, Keely A Muscatell and Michael R Irwin

    Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond

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    Vasiliki Michopoulos, Abigail Powers, Charles F Gillespie, Kerry J Ressler and Tanja Jovanovic

    Role of Inflammation in Suicide: From Mechanisms to Treatment

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    Lena Brundin, Elena Y Bryleva and Keerthi Thirtamara Rajamani

    The Role of the Immune System in Autism Spectrum Disorder

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    Amory Meltzer and Judy Van de Water

    Towards an Immunophenotype of Schizophrenia: Progress, Potential Mechanisms, and Future Directions

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    Brian J Miller and David R Goldsmith

    Microglia Priming with Aging and Stress

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    Anzela Niraula, John F Sheridan and Jonathan P Godbout

    Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation

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    Andrew H Miller, Ebrahim Haroon and Jennifer C Felger

    Hot Topics

    Dissecting Suicidality Using a Combined Genomic and Clinical Approach

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    Alexander B Niculescu and Helen Le-Niculescu

    Food Addiction and Obesity

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    Carrie R Ferrario

    The Emerging Role of Innate Immunity in Alzheimer’s Disease

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    Deepak Kumar Vijaya Kumar and Robert D Moir

    Pramipexole in Treatment Resistant-Depression, Possible Role of Inflammatory Cytokines

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    Rodrigo Escalona and Jan Fawcett

    Modeling the Impact of Social Contact on Substance Use

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    Mark A Smith and Justin C Strickland

    Impact on Cortical Function of Cocaine Abuse Co-Occurring with HIV

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    T Celeste Napier

    Mirror Neurons in Psychiatric Disorders: from Neuroception to Bio-behavioral System Dysregulation

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    Amedeo Minichino and Kristin Cadenhead

    The Cannabinoid Receptor 1 as a Key Mediator of Adolescent Behavior

    External Link

    Rainer Spanagel and Falk Kiefer

    Prospects for Medications to Reverse Causative Epigenetic Processes in Neuropsychiatry Disorders

    External Link

    Moshe Szyf

    Ketamine Mechanism of Action: Separating the Wheat from the Chaff

    External Link

    Todd D Gould, Panos Zanos and Carlos A Zarate Jr

    The Direct and Indirect Pathways of the Nucleus Accumbens are not What You Think

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    Yonatan M Kupchik and Peter W Kalivas

    Therapeutic Potential of Conjugated siRNAs for the Treatment of Major Depressive Disorder

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    Francesc Artigas and Analia Bortolozzi

    Error Processing in Depressive States: A Translational Opportunity?

    External Link

    Diego A Pizzagalli and William A Carlezon

    Imaging Adult Hippocampal Neurogenesis In Vivo

    External Link

    Jeremy S Biane and Mazen A Kheirbek

    Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets

    External Link

    Claes Wahlestedt

    REM Sleep on It!

    External Link

    Richard Boyce and Antoine Adamantidis

    The Neuroimmune Basis of Excessive Alcohol Consumption

    External Link

    Jody Mayfield and R Adron Harris

    Oxytocin-Augmented Psychotherapy: Beware of Context

    External Link

    René Hurlemann

    A Self-Generated Environmental Factor as a Potential Contributor to Atypical Early Social Communication in Autism

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    Takefumi Kikusui and Noboru Hiroi

  • Volume Eleven - Cannabis and Cannabinoids: From Synapse to Society

    Editorials

    Cannabis and Cannabinoids: From Synapse to Society

    External Link

    Margaret Haney and Matthew N Hill

    Reviews

    CB1 Receptor Signaling in the Brain: Extracting Specificity from Ubiquity

    External Link

    Arnau Busquets-Garcia, Jaideep Bains and Giovanni Marsicano

    The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development

    External Link

    Heidi C Meyer, Francis S Lee and Dylan G Gee

    Sex-Dependent Effects of Cannabis and Cannabinoids: A Translational Perspective

    External Link

    Ziva D Cooper and Rebecca M Craft

    The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain

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    Giulia Donvito, Sara R Nass, Jenny L Wilkerson, Zachary A Curry, Lesley D Schurman, Steven G Kinsey and Aron H Lichtman

    Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder

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    Matthew N Hill, Patrizia Campolongo, Rachel Yehuda and Sachin Patel

    Endocannabinoid Regulation of Reward and Reinforcement through Interaction with Dopamine and Endogenous Opioid Signaling

    External Link

    J M Wenzel and J F Cheer

    Preclinical Studies of Cannabinoid Reward, Treatments for Cannabis Use Disorder, and Addiction-Related Effects of Cannabinoid Exposure

    External Link

    Leigh V Panlilio and Zuzana Justinova

    Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol

    External Link

    Douglas L Boggs, Jacques D Nguyen, Daralyn Morgenson, Michael A Taffe and Mohini Ranganathan

    Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?

    External Link

    Cecilia J Hillard

    The Current State of Pharmacological Treatments for Cannabis Use Disorder and Withdrawal

    External Link

    Christina A Brezing and Frances R Levin

    US Epidemiology of Cannabis Use and Associated Problems

    External Link

    Deborah S Hasin

    Hot Topics

    Toward a Translationally Relevant Preclinical Model of Cannabis Use

    External Link

    Ryan J McLaughlin

    Setting the Legal Age for Access to Cannabis in Canada: Bridging Neuroscience, Policy, and Prevention

    External Link

    Rebecca J Haines-Saah and Emily K Jenkins

    Medical Cannabis Research: Issues and Priorities

    External Link

    Mark A Ware

    Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain

    External Link

    Val J Watts

    Novel Synthetic Opioids and Overdose Deaths: Tip of the Iceberg?

    External Link

    Michael H Baumann and Gavril W Pasternak

    Opioidergic regulation of pain and pleasure in human social relationships

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    Lauri Nummenmaa and Tomi Karjalainen

    Modulating Amygdala–Hippocampal Network Communication: A Potential Therapy for Neuropsychiatric Disorders

    External Link

    Jie Zheng and Jack J Lin

    Modeling Non-Syndromic Autism with Human-Induced Pluripotent Stem Cells

    External Link

    Luke AD Bury and Anthony Wynshaw-Boris

    Innovative Therapeutic Intervention For Opioid Use Disorder

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    F Gerard Moeller and Kathryn A Cunningham

    The Ketamine Metabolite 2R,6R-Hydroxynorketamine Blocks NMDA Receptors and Impacts Downstream Signaling Linked to Antidepressant Effects

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    Ege T Kavalali and Lisa M Monteggia

    Cognitive Signaling in Cerebellar Granule Cells

    External Link

    Mark J Wagner

    The Promise of Genome Editing for Modeling Psychiatric Disorders

    External Link

    Stephanie PB Caligiuri and Paul J Kenny

    Aggression Addiction and Relapse: A New Frontier in Psychiatry

    External Link

    Sam A Golden and Yavin Shaham

    Computational Approaches to Behavior Analysis in Psychiatry

    External Link

    Cheryl M Corcoran and Guillermo A Cecchi

    Cannabinoid Receptor 1 Positive Allosteric Modulators for Posttraumatic Stress Disorder

    External Link

    Anantha Shekhar and Ganesh A Thakur

    Integrating ‘Omics’ Approaches to Prioritize New Pathogenetic Mechanisms for Mental Disorders

    External Link

    Annamaria Cattaneo and Carmine M Pariante

    A Translational Model to Assess Sign-Tracking and Goal-Tracking Behavior in Children

    External Link

    Michelle A Joyner, Ashley N Gearhardt and Shelly B Flagel

    The Role of Mitochondrial Glutamate Metabolism in Cognitive Development and Disease

    External Link

    Ozan Baytaş and Eric M Morrow

    Cross-Species Neurophysiological Biomarkers of Attentional Dysfunction in Schizophrenia: Bridging the Translational Gap

    External Link

    Jared W Young and Gregory A Light

  • Volume Twelve - Sex Matters

    Editorials

    Sex matters

    External Link

    Tracy L. Bale

    Neuropsychopharmacology (NPP): gender balance in journal function

    External Link

    Chloe J. Jordan & William A. Carlezon Jr.

    Reviews

    Sex differences in psychiatric disorders: what we can learn from sex chromosome aneuploidies

    External Link

    Tamar Green, Shira Flash & Allan L. Reiss

    What has sex got to do with it? The role of hormones in the transgender brain

    External Link

    Hillary B. Nguyen, James Loughead, Emily Lipner, Liisa Hantsoo, Sara L. Kornfield & C. Neill Epperson

    Sex differences in neuroimmunity as an inherent risk factor

    External Link

    Margaret M. McCarthy

    Sex differences in the hypothalamic–pituitary–adrenal axis’ response to stress: an important role for gonadal hormones

    External Link

    Ashley L. Heck & Robert J. Handa

    Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures

    External Link

    Jill M. Goldstein, Taben Hale, Simmie L. Foster, Stuart A. Tobet & Robert J. Handa

    Sex differences in the developing brain: insights from multimodal neuroimaging

    External Link

    Antonia N. Kaczkurkin, Armin Raznahan & Theodore D. Satterthwaite

    Let’s call the whole thing off: evaluating gender and sex differences in executive function

    External Link

    Nicola M. Grissom & Teresa M. Reyes

    Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis

    External Link

    Johnathan M. Borland, James K. Rilling, Kyle J. Frantz & H. Elliott Albers

    Sex differences and the neurobiology of affective disorders

    External Link

    David R. Rubinow & Peter J. Schmidt

    Sex differences in stress reactivity in arousal and attention systems

    External Link

    Debra A. Bangasser, Samantha R. Eck & Evelyn Ordoñes Sanchez

    Sex differences in antidepressant efficacy

    External Link

    Tara A. LeGates, Mark D. Kvarta & Scott M. Thompson

    Neuronal and glial factors contributing to sex differences in opioid modulation of pain

    External Link

    Dayna L. Averitt, Lori N. Eidson, Hillary H. Doyle & Anne Z. Murphy

    Sex differences in neural mechanisms mediating reward and addiction

    External Link

    Jill B. Becker & Elena Chartoff

    Inflaming sex differences in mood disorders

    External Link

    Jennifer R. Rainville & Georgia E. Hodes

    Sex differences in hippocampal cognition and neurogenesis

    External Link

    Shunya Yagi & Liisa A. M. Galea

    Hot Topics

    Antidepressant potential of metabotropic glutamate receptor mGlu2 and mGlu3 negative allosteric modulators

    External Link

    Max E. Joffe & P. Jeffrey Conn

    Tinkering with THC-to-CBD ratios in Marijuana

    External Link

    Bertha K. Madras

    Sex differences in schizophrenia: estrogen and mitochondria

    External Link

    Vanessa F. Gonçalves, Ari B. Cuperfain & James L. Kennedy

    Vaccines to treat opioid use disorders and to reduce opioid overdoses

    External Link

    Carly Baehr & Marco Pravetoni

    Regulation of raphe serotonin neurons by serotonin 1A and 2B receptors

    External Link

    Arnauld Belmer & Luc Maroteaux

    Dynamic network targeting for closed-loop deep brain stimulation

    External Link

    Alexander B. Herman & Alik S. Widge

    NMDA-receptor independent actions of ketamine: a new chapter in a story that’s not so old

    External Link

    Nathan H. Wray & Mark M. Rasenick

    Lipid signalling in the mesolimbic dopamine pathway

    External Link

    Stephanie Fulton & Thierry Alquier

    Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau

    External Link

    Urmi Sengupta & Rakez Kayed

    Ovarian hormones, genes, and the brain: the case of estradiol and the brain-derived neurotrophic factor (BDNF) gene

    External Link

    Shau-Ming Wei & Karen F. Berman

    Sex differences in the incidence of antidepressant-induced mania (AIM) in bipolar disorders

    External Link

    Aislinn Williams & Melvin G. McInnis

    Guidance cues: linking drug use in adolescence with psychiatric disorders

    External Link

    Lauren M. Reynolds & Cecilia Flores

    The ventromedial prefrontal cortex: a putative locus for trait inattention

    External Link

    Matthew D. Albaugh & Alexandra S. Potter

    Are lithium effects dependent on genetic/epigenetic architecture?

    External Link

    Consuelo Walss-Bass & Gabriel R. Fries

    Unique treatment potential of cannabidiol for the prevention of relapse to drug use

    External Link

    Friedbert Weiss & Gustavo Gonzalez-Cuevas

    Positive-allosteric modulation of the 5-HT2C receptor: implications for neuropsychopharmacology and neurotherapeutics

    External Link

    Jia Zhou & Kathryn A. Cunningham

    Motion mapping in humans as a biomarker for psychiatric disorders

    External Link

    Ipsit V. Vahia & Brent P. Forester

    Treating cue-reactivity with brain stimulation: a new (transdiagnostic) approach

    External Link

    Colleen A. Hanlon

    Decoding the role of the microbiome on amygdala function and social behaviour

    External Link

    John F. Cryan & Timothy G. Dinan

    Novel models of drug relapse and craving after voluntary abstinence

    External Link

    Marco Venniro, Daniele Caprioli & Yavin Shaham

    An emerging epigenetic framework of systemic and central mechanisms underlying stress-related disorders

    External Link

    Carla Nasca, Natalie Rasgon & Bruce McEwen

  • Volume Thirteen - Sleep and Neuropsychiatric Illness

    Editorials

    Sleep and neuropsychiatric illness

    External Link

    John W. Winkelman & Luis de Lecea

    Perspective: Drugs, sleep, and the addicted brain

    External Link

    Rita J. Valentino & Nora D. Volkow

    Reviews

    Arousal and sleep circuits

    External Link

    Barbara E. Jones

    Sleep deprivation, vigilant attention, and brain function: a review

    External Link

    Amanda N. Hudson, Hans P. A. Van Dongen & Kimberly A. Honn

    Neurochemical mechanisms for memory processing during sleep: basic findings in humans and neuropsychiatric implications

    External Link

    Gordon B. Feld & Jan Born

    Genetics of the human circadian clock and sleep homeostat

    External Link

    Liza H. Ashbrook, Andrew D. Krystal, Ying-Hui Fu & Louis J. Ptáček

    Sleep disturbance in PTSD and other anxiety-related disorders: an updated review of clinical features, physiological characteristics, and psychological and neurobiological mechanisms

    External Link

    Anne Richards, Jennifer C. Kanady & Thomas C. Neylan

    Sleep, insomnia, and depression

    External Link

    Dieter Riemann, Lukas B. Krone, Katharina Wulff & Christoph Nissen

    Sleep as a translationally-relevant endpoint in studies of autism spectrum disorder (ASD)

    External Link

    Galen Missig, Christopher J. McDougle & William A. Carlezon Jr.

    Bidirectional relationship between sleep and Alzheimer’s disease: role of amyloid, tau, and other factors

    External Link

    Chanung Wang & David M. Holtzman

    Sleep in Parkinson’s disease

    External Link

    Ambra Stefani & Birgit Högl

    Sleep and neurological autoimmune diseases

    External Link

    Alex Iranzo

    Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework

    External Link

    George F. Koob & Ian M. Colrain

    Sleep therapeutics and neuropsychiatric illness

    External Link

    Andrew D. Krystal

    Sleep in the United States Military

    External Link

    Cameron H. Good, Allison J. Brager, Vincent F. Capaldi & Vincent Mysliwiec

    Integrating sleep, neuroimaging, and computational approaches for precision psychiatry

    External Link

    Andrea N. Goldstein-Piekarski, Bailey Holt-Gosselin, Kathleen O’Hora & Leanne M. Williams

    Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications

    External Link

    Monika Haack, Norah Simpson, Navil Sethna, Satvinder Kaur & Janet Mullington

    Hot Topics

    MDMA enhances pleasantness of affective touch

    External Link

    Harriet de Wit & Anya K. Bershad

    Intra-individual changes in methylome profiles: an epigenetic ‘scar’ of early-life adversity?

    External Link

    Ali Mortazavi & Tallie Z. Baram

    The upside of stress: a mechanism for the positive motivational role of corticotropin releasing factor

    External Link

    Julia C. Lemos & Veronica A. Alvarez

    Dopamine release drives motivation, independently from dopamine cell firing

    External Link

    Ali Mohebi & Joshua D. Berke

    Physiological roles for neuromodulation via Gi/o GPCRs working through Gβγ–SNARE interaction

    External Link

    Heidi E. Hamm & Simon T. Alford

    The striatum specifies the statistics of behavior

    External Link

    Jeffrey E. Markowitz & Sandeep Robert Datta

    Contributions of nonneuronal brain cells in substance use disorders

    External Link

    Kathryn J. Reissner & Mikhail V. Pletnikov

    TRPV1 and MOR working in tandem: implications for pain and opioids use

    External Link

    Nasser Abdullah & Christophe Altier

    Towards objective definition of psychopathology in post-traumatic stress disorder

    External Link

    Amit Etkin

    Linking actions with their consequences within the ventrolateral orbital cortex

    External Link

    Dan C. Li & Shannon L. Gourley

    Regulation of fear extinction and relapse by hippocampal engrams

    External Link

    Michael R. Drew & Emma T. Brockway

    The complexity of pharmacology of cannabidiol (CBD) and its implications in the treatment of brain disorders

    External Link

    Sonja Elsaid & Bernard Le Foll

    Is depression a disorder of electrical brain networks?

    External Link

    Yael Grossman & Kafui Dzirasa

    MDMA-assisted psychotherapy for posttraumatic stress disorder: A promising novel approach to treatment

    External Link

    Eric Vermetten & Rachel Yehuda

    Spatial transcriptomics: putting genome-wide expression on the map

    External Link

    K. R. Maynard, A. E. Jaffe & K. Martinowich

    Role for kappa-opioid system in stress-induced cocaine use uncovered with PET

    External Link

    Derek Blevins & Diana Martinez

    Targeting neuroinflammation with brain penetrant P2X7 antagonists as novel therapeutics for neuropsychiatric disorders

    External Link

    Anindya Bhattacharya & Marc Ceusters

    Biological fingerprints for psychosis

    External Link

    Carol A. Tamminga & Brett A. Clementz

    Selection criteria for neurophysiologic biomarkers to accelerate the pace of CNS therapeutic development

    External Link

    Gregory A. Light & Neal R. Swerdlow

    Sleep and EEG biomarkers as avenues toward new treatment approaches in Angelman syndrome

    External Link

    Christopher J. McDougle & Christopher J. Keary

  • Volume Fourteen - Big data in Psychiatry: Multiomics, Neuroimaging, Computational Modeling, and Digital Phenotyping

    Editorials

    Big data in psychiatry: multiomics, neuroimaging, computational modeling, and digital phenotyping

    External Link

    Kerry J. Ressler & Leanne M. Williams

    Reviews

    Advances in the computational understanding of mental illness

    External Link

    Quentin J. M. Huys, Michael Browning, Martin P. Paulus & Michael J. Frank

    Modeling brain, symptom, and behavior in the winds of change

    External Link

    David M. Lydon-Staley, Eli J. Cornblath, Ann Sizemore Blevins & Danielle S. Bassett

    Big behavior: challenges and opportunities in a new era of deep behavior profiling

    External Link

    Lukas von Ziegler, Oliver Sturman & Johannes Bohacek

    Opportunities and challenges in the collection and analysis of digital phenotyping data

    External Link

    Jukka-Pekka Onnela

    Leveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders

    External Link

    Veronica B. Searles Quick, Belinda Wang & Matthew W. State

    PsychENCODE and beyond: transcriptomics and epigenomics of brain development and organoids

    External Link

    Alexandre Jourdon, Soraya Scuderi, Davide Capauto, Alexej Abyzov & Flora M. Vaccarino

    Interpretation of psychiatric genome-wide association studies with multispecies heterogeneous functional genomic data integration

    External Link

    Timothy Reynolds, Emma C. Johnson, Spencer B. Huggett, Jason A. Bubier, Rohan H. C. Palmer, Arpana Agrawal, Erich J. Baker & Elissa J. Chesler

    Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau

    External Link

    Sruti Rayaprolu, Lenora Higginbotham, Pritha Bagchi, Caroline M. Watson, Tian Zhang, Allan I. Levey, Srikant Rangaraju & Nicholas T. Seyfried

    Signature-based approaches for informed drug repurposing: targeting CNS disorders

    External Link

    Rammohan Shukla, Nicholas D. Henkel, Khaled Alganem, Abdul-rizaq Hamoud, James Reigle, Rawan S. Alnafisah, Hunter M. Eby, Ali S. Imami, Justin F Creeden, Scott A. Miruzzi, Jaroslaw Meller & Robert E. Mccullumsmith

    The ABCD study: understanding the development of risk for mental and physical health outcomes

    External Link

    Nicole R. Karcher & Deanna M. Barch

    Biotyping in psychosis: using multiple computational approaches with one data set

    External Link

    Carol A. Tamminga, Brett A. Clementz, Godfrey Pearlson, Macheri Keshavan, Elliot S. Gershon, Elena I. Ivleva, Jennifer McDowell, Shashwath A. Meda, Sarah Keedy, Vince D. Calhoun, Paulo Lizano, Jeffrey R. Bishop, Matthew Hudgens-Haney, Ney Alliey-Rodriguez, Huma Asif & Robert Gibbons

    Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics

    External Link

    Amanda M. Buch & Conor Liston

    Deep learning for small and big data in psychiatry

    External Link

    Georgia Koppe, Andreas Meyer-Lindenberg & Daniel Durstewitz

    Digital health data-driven approaches to understand human behavior

    External Link

    Lisa A. Marsch

    Real-time mobile monitoring of bipolar disorder: a review of evidence and future directions

    External Link

    Gideon P. Dunster, Joel Swendsen & Kathleen Ries Merikangas

    Toward dynamic phenotypes and the scalable measurement of human behavior

    External Link

    Laura Germine, Roger W. Strong, Shifali Singh & Martin J. Sliwinski

    Hot Topics

    Covid-19 and promising solutions to combat symptoms of stress, anxiety and depression

    External Link

    Deniz Vatansever, Shouyan Wang & Barbara J. Sahakian

    Imaging suicidal thoughts and behavior: the promise of computational models

    External Link

    Anne-Laura van Harmelen, Lianne Schmaal & Hilary P. Blumberg

    Critical roles for developmental hormones and genetic sex in stress-induced transcriptional changes associated with depression

    External Link

    Marianne L. Seney & Ryan W. Logan

    EEG microstate sequences suggest abnormally chaotic brain dynamics in psychosis

    External Link

    Michael Murphy & Dost Öngür

    DNA methylation clock associated with age-related illnesses is accelerated in PTSD

    External Link

    Ruoting Yang & Gwyneth W. Y. Wu

    Astrocyte adenosine signaling and neural mechanisms of goal-directed and habitual reward-seeking behaviors

    External Link

    Seungwoo Kang & Doo-Sup Choi

    A prefrontal social circuit vulnerable to juvenile social isolation

    External Link

    Hirofumi Morishita

    Biologically plausible models of neural dynamics for rapid-acting antidepressant interventions

    External Link

    Jessica R. Gilbert & Carlos A. Zarate Jr.

    The critical importance in identifying the biological mechanisms underlying the effects of racism on mental health

    External Link

    Tracy L. Bale & Tanja Jovanovic

    Chromatin architecture provides a roadmap to improve our understanding of psychiatric disorders

    External Link

    Benxia Hu & Hyejung Won

    Targeting persistent stress-enhanced memory through microRNAs

    External Link

    Stephanie E. Sillivan & Courtney A. Miller

    Dimensional approaches to understanding threat conditioning and extinction in anxiety

    External Link

    Marie-France Marin & Mohammed R. Milad

    “Next up for psychiatry: rejection sensitivity and the social brain”

    External Link

    David T. Hsu & Johanna M. Jarcho

    Genetic and epigenetic modulation of the oxytocin receptor and implications for autism

    External Link

    Elissar Andari & James K. Rilling

    Computational phenotyping and longitudinal dynamics to inform clinical decision-making in psychiatry

    External Link

    Michele Ferrante & Joshua A. Gordon

    Reinforcing actions through the thalamostriatal circuit

    External Link

    Kari A. Johnson & David M. Lovinger

    Self-administered fentanyl profoundly impacts rat brain innate immune targets

    External Link

    Irma E. Cisneros & Kathryn A. Cunningham

    Catecholamine signaling that modulates cerebellar operations in cognition

    External Link

    Hirofumi Fujita & Erik S. Carlson

    Machine-learning approaches to classify and understand emotion states in mice

    External Link

    Nejc Dolensek & Nadine Gogolla

    Applied natural language processing in mental health big data

    External Link

    Robert Stewart & Sumithra Velupillai

    Linking cell types to behavior in the vertebrate hypothalamus

    External Link

    Matthew Lovett-Barron

    GWAS meets transcriptomics: from genetic letters to transcriptomic words of neuropsychiatric risk

    External Link

    Chris Chatzinakos, Foivos Georgiadis & Nikolaos P. Daskalakis

    Plasma psilocin critically determines behavioral and neurobiological effects of psilocybin

    External Link

    Martin K. Madsen & Gitte M. Knudsen

    Serotonin minting new mitochondria in cortical neurons: implications for psychopathology

    External Link

    Sashaina E. Fanibunda & Vidita A. Vaidya

    Better living through chemistry: MDMA’s prosocial mechanism as a starting point for improved therapeutics

    External Link

    Boris D. Heifets & Robert C. Malenka

    NIDA vision for big data science to understand the biological underpinnings of substance use disorders

    External Link

    Susan N. Wright & A. Roger Little

    Using the exposome to understand environmental contributors to psychiatric disorders

    External Link

    James P. Burkett & Gary W. Miller

    Opioids and maternal brain–behavior adaptation

    External Link

    James E. Swain & S. Shaun Ho

    Habenular TCF7L2 links nicotine addiction to diabetes: the broad significance

    External Link

    Stephanie P. B. Caligiuri & Paul J. Kenny

  • Volume Fifteen - Prefrontal Cortex

    Editorials

    The prefrontal cortex

    External Link

    Suzanne N. Haber & Trevor Robbins

    Reviews

    Evolution of prefrontal cortex

    External Link

    Todd M. Preuss & Steven P. Wise

    Prefrontal connectomics: from anatomy to human imaging

    External Link

    Suzanne N. Haber, Hesheng Liu, Jakob Seidlitz & Ed Bullmore

    Development of prefrontal cortex

    External Link

    Sharon M. Kolk & Pasko Rakic

    Computational models of adaptive behavior and prefrontal cortex

    External Link

    Alireza Soltani & Etienne Koechlin

    The role of prefrontal cortex in cognitive control and executive function

    External Link

    Naomi P. Friedman & Trevor W. Robbins

    The role of PFC networks in cognitive control and executive function

    External Link

    Vinod Menon & Mark D’Esposito

    Advances in modeling learning and decision-making in neuroscience

    External Link

    Anne G. E. Collins & Amitai Shenhav

    The prefrontal cortex and (uniquely) human cooperation: a comparative perspective

    External Link

    Yoonseo Zoh, Steve W. C. Chang & Molly J. Crockett

    Foraging with the frontal cortex: A cross-species evaluation of reward-guided behavior

    External Link

    Peter H. Rudebeck & Alicia Izquierdo

    Reinforcement-learning in fronto-striatal circuits

    External Link

    Bruno Averbeck & John P. O’Doherty

    Prefrontal cortex and depression

    External Link

    Diego A. Pizzagalli & Angela C. Roberts

    Prefrontal cortex interactions with the amygdala in primates

    External Link

    Elisabeth A. Murray & Lesley K. Fellows

    The prefrontal cortex and OCD

    External Link

    Susanne E. Ahmari & Scott L. Rauch

    Interactions between ventrolateral prefrontal and anterior cingulate cortex during learning and behavioural change

    External Link

    Ilya E. Monosov & Matthew F. S. Rushworth

    Prefrontal-hippocampal interactions supporting the extinction of emotional memories: the retrieval stopping model

    External Link

    Michael C. Anderson & Stan B. Floresco

    Prefrontal cortex, amygdala, and threat processing: implications for PTSD

    External Link

    M. Alexandra Kredlow, Robert J. Fenster, Emma S. Laurent, Kerry J. Ressler & Elizabeth A. Phelps

    The prefrontal cortex, pathological anxiety, and anxiety disorders

    External Link

    Margaux M. Kenwood, Ned H. Kalin & Helen Barbas

    The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex

    External Link

    Ahmet O. Ceceli, Charles W. Bradberry & Rita Z. Goldstein

    Mechanisms underlying dorsolateral prefrontal cortex contributions to cognitive dysfunction in schizophrenia

    External Link

    Jason Smucny, Samuel J. Dienel, David A. Lewis & Cameron S. Carter

    Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine

    External Link

    Roshan Cools & Amy F. T. Arnsten

    Prefrontal contributions to the stability and variability of thought and conscious experience

    External Link

    Andre Zamani, Robin Carhart-Harris & Kalina Christoff

    The prefrontal cortex and neurosurgical treatment for intractable OCD

    External Link

    Steven A. Rasmussen & Wayne K. Goodman

    Noninvasive neuromodulation of the prefrontal cortex in mental health disorders

    External Link

    William T. Regenold, Zhi-De Deng & Sarah H. Lisanby

    Hot Topics

    Recent findings on the role of sensory and interoceptive-related circuits in relapse to drug seeking

    External Link

    David J. Reiner & Yavin Shaham

    PFC neuromodulation with theta burst stimulation to impact behavior and neural network activity in schizophrenia and bipolar disorder

    External Link

    Fabio Ferrarelli & Mary L. Phillips

    Thinner cortices in high-risk offspring: the promises of big data

    External Link

    Myrna M. Weissman & Ardesheer Talati

    Identifying subtypes of PTSD to promote precision medicine

    External Link

    Carole Siegel & Eugene Laska

    First in vivo evaluations of synaptic density alterations in the brain

    External Link

    Irina Esterlis & Sophie Holmes

    New myelin for old memories

    External Link

    Michael C. Kern & Mazen A. Kheirbek

    The paraventricular nucleus of the thalamus and its potential role in psychopathology

    External Link

    Shelly B. Flagel

    MicroRNAs as promising peripheral sensors of prefrontal cortex developmental trajectory and psychiatric risk

    External Link

    Alice Morgunova & Cecilia Flores

    Developing breakthrough psychiatric treatments by modulating G protein-coupled receptors on prefrontal cortex somatostatin interneurons

    External Link

    Nicole A. Crowley & Max E. Joffe

    Super glue: emerging roles for non-neuronal brain cells in mental health

    External Link

    William A. Carlezon Jr & Galen Missig

    Brain-enriched CACNA1C isoforms as novel, selective targets for psychiatric indications

    External Link

    Nicola A. L. Hall & Elizabeth M. Tunbridge

    Densely sampled neuroimaging for maximizing clinical insight in psychiatric and addiction disorders

    External Link

    Sarah W. Yip & Anna B. Konova

    Orexin modulation of stress reactivity as a novel targeted treatment for anxiety and alcohol use disorder

    External Link

    Stephanie M. Gorka & K. Luan Phan

    Novel approaches to estimate prefrontal synaptic strength in vivo in humans: of relevance to depression, schizophrenia, and ketamine

    External Link

    Chadi G. Abdallah & Graeme F. Mason

    “Archealization” of human brain organoids

    External Link

    Alysson R. Muotri

    Leveraging resting-state neurophenotypes to identify susceptibility to and heterogeneity of posttraumatic stress disorder

    External Link

    Nathaniel G. Harnett & Lauren A. M. Lebois

    Disease-modifying pharmacological approaches to correcting basal forebrain cholinergic neuronal (BFCN) dysfunction and degeneration

    External Link

    John J. Alam & Ralph A. Nixon

    Brain sex differences: the androgynous brain is advantageous for mental health and well-being

    External Link

    Qiang Luo & Barbara J. Sahakian

    The prenatal environment and risk for mental illness in young people

    External Link

    Joshua L. Roffman & Erin C. Dunn

    Mobile DNA and the brain

    External Link

    Amy C. Lossie & Jonathan D. Pollock

    The evolution of the psychedelic revolution

    External Link

    Lindsay P. Cameron & David E. Olson

    Mapping causal generators of appetitive motivation-hedonic functions in frontal cortex

    External Link

    Brian A. Baldo & Kent C. Berridge

    “Neuroanatomical integration of homeostatic and hedonic brain regions to regulate consummatory behavior”

    External Link

    Ashley E. Smith & Jonathan D. Hommel

    Acute effects of a high-fat diet on estrous cycling and body weight of intact female mice

    External Link

    Melissa E. Lenert & Michael D. Burton

    Identifying novel mechanisms and treatment targets for irritability and aggression in psychiatric disorders

    External Link

    Manish Kumar Jha & Madhukar H. Trivedi

    Precision medicine in psychiatry: biomarkers to the forefront

    External Link

    Alexander B. Niculescu & Helen Le-Niculescu

  • Volume Sixteen - Synaptic plasticity as a therapeutic target to modulate circuits in psychiatric disorders

    Editorials

    Synaptic plasticity as a therapeutic target to modulate circuits in psychiatric disorders

    External Link

    Marina E. Wolf & Anissa Abi-Dargham

    Reviews

    Net gain and loss: influence of natural rewards and drugs of abuse on perineuronal nets

    External Link

    Travis E. Brown & Barbara A. Sorg

    Astrocyte regulation of synaptic signaling in psychiatric disorders

    External Link

    Anna Kruyer, Peter W. Kalivas & Michael D. Scofield

    Endocannabinoids at the synapse and beyond: implications for neuropsychiatric disease pathophysiology and treatment

    External Link

    Andrew Scheyer, Farhana Yasmin, Saptarnab Naskar & Sachin Patel

    Rapid homeostatic plasticity and neuropsychiatric therapeutics

    External Link

    Ege T. Kavalali & Lisa M. Monteggia

    Sleep-mediated regulation of reward circuits: implications in substance use disorders

    External Link

    Rong Guo, Dylan Thomas Vaughan, Ana Lourdes Almeida Rojo & Yanhua H. Huang

    Neural circuits regulating prosocial behaviors

    External Link

    Jessica J. Walsh, Daniel J. Christoffel & Robert C. Malenka

    Plasticity of synapses and reward circuit function in the genesis and treatment of depression

    External Link

    Scott M. Thompson

    Towards an understanding of psychedelic-induced neuroplasticity

    External Link

    Abigail E. Calder & Gregor Hasler

    Synaptic plasticity and mental health: methods, challenges and opportunities

    External Link

    Lawrence G. Appelbaum, Mohammad Ali Shenasa, Louise Stolz & Zafiris Daskalakis

    Adaptive control of synaptic plasticity integrates micro- and macroscopic network function

    External Link

    Daniel N. Scott & Michael J. Frank

    Sustained effects of single doses of classical psychedelics in humans

    External Link

    Gitte M. Knudsen

    Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes

    External Link

    Oliver D. Howes, Connor Cummings, George E. Chapman & Ekaterina Shatalina

    Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity

    External Link

    Sophia Vinogradov, Matthew V. Chafee, Erik Lee & Hirofumi Morishita

    Imaging synaptic density in depression

    External Link

    Sophie E. Holmes, Chadi Abdallah & Irina Esterlis

    Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation

    External Link

    Ali Jannati, Lindsay M. Oberman, Alexander Rotenberg & Alvaro Pascual-Leone

    Hot Topics

    Using metabolic imaging to investigate neuromodulatory mechanisms of rTMS

    External Link

    Joseph A. Deluisi & Desmond J. Oathes

    Schrooms against booze: Potential of mycotherapy for the treatment of AUD

    External Link

    Marcus W. Meinhardt & Wolfgang H. Sommer

    Neurotrophic effects of potentiating gaba-mediated dendritic inhibition

    External Link

    Thomas D. Prevot & Etienne Sibille

    Does the trip matter? Investigating the role of the subjective effects of psychedelics in persisting therapeutic effects

    External Link

    Katherine M. Nautiyal & David B. Yaden

    Probing long-term potentiation-like visual cortical plasticity in humans using repeated visual stimulation: effects on visual evoked potentials

    External Link

    Holly K. Hamilton & Daniel H. Mathalon

    Neuroimaging of plasticity mechanisms in the human brain: from critical periods to psychiatric conditions

    External Link

    Valerie J. Sydnor & Theodore D. Satterthwaite

    N6-methyladenosine (m6A) epitranscriptomics in synaptic plasticity and behaviors

    External Link

    Emir Malovic & Subhash C. Pandey

    Plasticity markers in the human brain associated with rapid antidepressants

    External Link

    Joshua S. Siegel & Ginger E. Nicol

    The role of racial discrimination in dissociation and interoceptive dysfunction

    External Link

    Negar Fani & Sahib S. Khalsa

    Sleep disturbance in substance use disorders: the orexin (hypocretin) system as an emerging pharmacological target

    External Link

    Utsav Gyawali & Morgan H. James

    The double-edged sword of the double-stranded break

    External Link

    Robert J. Fenster & Junghyup Suh

    Beyond the hypothalamus: roles for insulin as a regulator of neurotransmission, motivation, and feeding

    External Link

    Carrie R. Ferrario & Julie E. Finnell

    Unexpected circuit-level tradeoffs in human stress resilience

    External Link

    Jennifer S. Stevens & Alyssa R. Roeckner

    Echoes of ancient DNA in living modern humans affect risk for neuropsychiatric disease and brain structure and function of networks subserving higher-order cognition

    External Link

    Michael D. Gregory & Karen F. Berman

    Real-time fMRI neurofeedback: the promising potential of brain-training technology to advance clinical neuroscience

    External Link

    Stephan F. Taylor & Meghan E. Martz

    Shaping long-range functional connectivity through prefrontal interneuron plasticity

    External Link

    David A. Kupferschmidt & Joshua A. Gordon

    Single-cell transcriptional profiling in brain reward structures

    External Link

    Jeremy J. Day & Keri Martinowich

    Blood-based biomarkers for suicide in depression: moving a step closer to prediction

    External Link

    Firoza Mamdani & Adolfo Sequeira

    Epigenetic aging in psychiatry: clinical implications and therapeutic opportunities

    External Link

    Camila N. C. Lima & Gabriel R. Fries

    How much is too much? New evidence associating low levels of prenatal alcohol exposure with brain differences in children

    External Link

    Catherine Lebel & Xiangyu Long

    Reaching for the unreachable: low intensity focused ultrasound for non-invasive deep brain stimulation

    External Link

    Noah S. Philip & Amanda R. Arulpragasam

    Targeted and transient opening of the blood brain barrier in discrete neurocircuits and brain regions

    External Link

    Nicole A. Crowley & Scott H. Medina

    The promise of 3,4-methylenedioxymethamphetamine (MDMA) in combination with prolonged exposure therapy for posttraumatic stress disorder

    External Link

    Barbara O. Rothbaum & Jessica L. Maples-Keller

    Synaptic plasticity of the orbitofrontal cortex in obesity

    External Link

    Lauren T. Seabrook & Stephanie L. Borgland

  • Volume Seventeen - Rapid and Novel Treatments in Psychiatry

    Editorials

    Rapid and novel treatments in psychiatry: the future is now

    External Link

    Carolyn I. Rodriguez & Charles F. Zorumski

    Perspectives

    Finding new and better treatments for psychiatric disorders

    External Link

    No time to lose: the current state of research in rapid-acting psychotherapeutics

    External Link

    The Brain & Behavior Research Foundation’s philanthropic support for neuropsychiatric research

    External Link

    Navigating the FDA regulatory landscape

    External Link

    Are novel treatments for brain disorders hiding in plain sight?

    External Link

    Pharmacogenomic testing for antidepressant treatment selection: lessons learned and roadmap forward

    External Link

    Electronic health records and stratified psychiatry: bridge to precision treatment?

    External Link

    Ethical considerations in rapid and novel treatments in psychiatry

    External Link

    Ensuring psychedelic treatments and research do not leave anyone behind

    External Link

    Reviews

    Ketamine in neuropsychiatric disorders: an update

    External Link

    Jenessa N. Johnston, Bashkim Kadriu, Christoph Kraus, Ioline D. Henter & Carlos A. Zarate Jr

    Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms

    External Link

    John H. Krystal, Ege T. Kavalali & Lisa M. Monteggia

    Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry

    External Link

    Jesse E. Hanson, Hongjie Yuan, Riley E. Perszyk, Tue G. Banke, Hao Xing, Ming-Chi Tsai, Frank S. Menniti & Stephen F. Traynelis

    Novel neurosteroid therapeutics for post-partum depression: perspectives on clinical trials, program development, active research, and future directions

    External Link

    Riah Patterson, Irina Balan, A. Leslie Morrow & Samantha Meltzer-Brody

    Neurosteroids: mechanistic considerations and clinical prospects

    External Link

    Jamie L. Maguire & Steven Mennerick

    Modulators of GABAA receptor-mediated inhibition in the treatment of neuropsychiatric disorders: past, present, and future

    External Link

    Scott M. Thompson

    Psychedelic therapies reconsidered: compounds, clinical indications, and cautious optimism

    External Link

    Jennifer M. Mitchell & Brian T. Anderson

    Therapeutic mechanisms of psychedelics and entactogens

    External Link

    Boris D. Heifets & David E. Olson

    Psychedelics: preclinical insights provide directions for future research

    External Link

    Ryan H. Gumpper & Bryan L. Roth

    Accelerated TMS - moving quickly into the future of depression treatment

    External Link

    Sanne J. H. van Rooij, Amanda R. Arulpragasam, William M. McDonald & Noah S. Philip

    Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity

    External Link

    Alik S. Widge

    How electroconvulsive therapy works in the treatment of depression: is it the seizure, the electricity, or both?

    External Link

    Zhi-De Deng, Pei L. Robins, William Regenold, Paul Rohde, Moritz Dannhauer & Sarah H. Lisanby

    Closed-loop neurostimulation for the treatment of psychiatric disorders

    External Link

    Kristin K. Sellers, Joshua L. Cohen, Ankit N. Khambhati, Joline M. Fan, A. Moses Lee, Edward F. Chang & Andrew D. Krystal

    The future of brain circuit-targeted therapeutics

    External Link

    Shan H. Siddiqi, Sanaz Khosravani, John D. Rolston & Michael D. Fox

    The why, when, where, how, and so what of so-called rapidly acting antidepressants

    External Link

    Alan F. Schatzberg & Sanjay J. Mathew

    How should we design future mechanistic and/or efficacy clinical trials?

    External Link

    Maurizio Fava

    Digital and precision clinical trials: innovations for testing mental health medications, devices, and psychosocial treatments

    External Link

    Eric Lenze, John Torous & Patricia Arean

    Advancing preclinical chronic stress models to promote therapeutic discovery for human stress disorders

    External Link

    Trevonn M. Gyles, Eric J. Nestler & Eric M. Parise

    The role of neurotrophic factors in novel, rapid psychiatric treatments

    External Link

    Jihye Kim, Michelle J. He, Alina K. Widmann & Francis S. Lee

    Antidepressants enter cells, organelles, and membranes

    External Link

    Zack Blumenfeld, Kallol Bera, Eero Castrén & Henry A. Lester

    Novel mechanism-based treatments for pediatric anxiety and depressive disorders

    External Link

    Chad M. Sylvester, Joan L. Luby & Daniel S. Pine

    Hot Topics

    Cell type specific focused ultrasound neuromodulation in preclinical models of sleep and psychiatric disorders

    External Link

    Keith R. Murphy & Luis de Lecea

    Disassociating drug active ingredients from inactive: ketamine-like synaptic effects of a ketamine excipient

    External Link

    Kyle A. Brown & Todd D. Gould

    Unraveling the cell-type-specific molecular pathways of PTSD: integrating GWAS with brain genomic profiling and in vitro modeling

    External Link

    Artemis Iatrou & Nikolaos P. Daskalakis

    Potential applications of temporal interference deep brain stimulation for the treatment of transdiagnostic conditions in psychiatry

    External Link

    Negar Fani & Michael T. Treadway

    Kynurenic acid: translational perspectives of a therapeutically targetable gliotransmitter

    External Link

    Ana Pocivavsek & Sophie Erhardt

    Neurobiology and treatment advances for prolonged grief disorder

    External Link

    Zoe R. Donaldson & M. Katherine Shear

    A novel rat model of potentiated incubation of opioid craving after abstinence induced by adverse consequences of drug seeking

    External Link

    Ida Fredriksson & Yavin Shaham

    Herpesviruses and neuropsychiatric disorders: overlooked adversaries or innocent bystanders?

    External Link

    Haixia Zheng & Jonathan Savitz

    Exploring the role of mu opioid receptors in the therapeutic potential and abuse liability of (S)-ketamine

    External Link

    Marjorie R. Levinstein & Michael Michaelides

    Repurposing anti-inflammatory medications for alcohol and substance use disorders

    External Link

    Angela R. Ozburn & Sade M. Spencer

    Integrating public health and translational basic science to address challenges of xylazine adulteration of fentanyl

    External Link

    Cassandra D. Gipson & Justin C. Strickland

    A path to novel, effective treatments for schizophrenia

    External Link

    Thomas W. Weickert & Cynthia Shannon Weickert

    Moving beyond descriptive nosology: an argument for negative valence systems disorder

    External Link

    Elizabeth K. Lucas & Robert E. McCullumsmith

    From high-throughput transcriptome characterization of individual synaptosomes to constructing the whole-brain connectome

    External Link

    Muchun Niu & Chenghang Zong

    Swell1 channel-mediated tonic GABA release from astrocytes modulates cocaine reward

    External Link

    Junhua Yang & Zhaozhu Qiu

    The orexin neurotransmitter system as a target for medication development for opioid use disorder

    External Link

    A. S. Huhn & K. E. Dunn

    A unique role for cAMP signaling in microglia during opioid tolerance and withdrawal

    External Link

    Kevin R. Coffey & John F. Neumaier

    Epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid overdose

    External Link

    An T. Hoang & Olivia Corradin

    Leveraging AI to predict substance use disorder treatment outcomes

    External Link

    Salvatore Giorgi & Brenda Curtis

    The biological embedding of structural inequities: new insight from neuroscience

    External Link

    E. Kate Webb & Nathaniel G. Harnett

    Potentiation of AMPA receptors for rapid therapeutic gain in psychiatry has reached a new level of excitement

    External Link

    Jeffrey M. Witkin & Arnold Lippa

    Central amygdala CRF1 cells control nociception and anxiety-like behavior

    External Link

    Marcus M. Weera & Nicholas W. Gilpin

    Gene–brain–behavior mechanisms underlying autism spectrum disorder: implications for precision psychiatry

    External Link

    Amanda M. Buch & Conor Liston

    Microbes and mental health: translating preclinical findings to the clinic

    External Link

    Cherise R. Chin Fatt & Madhukar H. Trivedi

    Towards personalized medicine: subtyping using functional profiles

    External Link

    Gunner Drossel & Anna Zilverstand

    Postmortem-derived iPSC models in substance use disorders research

    External Link

    Emily Frances Mendez & Consuelo Walss-Bass

    Transcranial focused ultrasound (tFUS): a promising noninvasive deep brain stimulation approach for pain

    External Link

    Bashar W. Badran & Xiaolong Peng