Editorials

Synaptic plasticity as a therapeutic target to modulate circuits in psychiatric disorders

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Marina E. Wolf & Anissa Abi-Dargham

Reviews

Net gain and loss: influence of natural rewards and drugs of abuse on perineuronal nets

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Travis E. Brown & Barbara A. Sorg

Astrocyte regulation of synaptic signaling in psychiatric disorders

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Anna Kruyer, Peter W. Kalivas & Michael D. Scofield

Endocannabinoids at the synapse and beyond: implications for neuropsychiatric disease pathophysiology and treatment

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Andrew Scheyer, Farhana Yasmin, Saptarnab Naskar & Sachin Patel

Rapid homeostatic plasticity and neuropsychiatric therapeutics

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Ege T. Kavalali & Lisa M. Monteggia

Sleep-mediated regulation of reward circuits: implications in substance use disorders

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Rong Guo, Dylan Thomas Vaughan, Ana Lourdes Almeida Rojo & Yanhua H. Huang

Neural circuits regulating prosocial behaviors

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Jessica J. Walsh, Daniel J. Christoffel & Robert C. Malenka

Plasticity of synapses and reward circuit function in the genesis and treatment of depression

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Scott M. Thompson

Towards an understanding of psychedelic-induced neuroplasticity

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Abigail E. Calder & Gregor Hasler

Synaptic plasticity and mental health: methods, challenges and opportunities

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Lawrence G. Appelbaum, Mohammad Ali Shenasa, Louise Stolz & Zafiris Daskalakis

Adaptive control of synaptic plasticity integrates micro- and macroscopic network function

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Daniel N. Scott & Michael J. Frank

Sustained effects of single doses of classical psychedelics in humans

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Gitte M. Knudsen

Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes

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Oliver D. Howes, Connor Cummings, George E. Chapman & Ekaterina Shatalina

Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity

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Sophia Vinogradov, Matthew V. Chafee, Erik Lee & Hirofumi Morishita

Imaging synaptic density in depression

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Sophie E. Holmes, Chadi Abdallah & Irina Esterlis

Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation

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Ali Jannati, Lindsay M. Oberman, Alexander Rotenberg & Alvaro Pascual-Leone

Hot Topics

Using metabolic imaging to investigate neuromodulatory mechanisms of rTMS

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Joseph A. Deluisi & Desmond J. Oathes

Schrooms against booze: Potential of mycotherapy for the treatment of AUD

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Marcus W. Meinhardt & Wolfgang H. Sommer

Neurotrophic effects of potentiating gaba-mediated dendritic inhibition

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Thomas D. Prevot & Etienne Sibille

Does the trip matter? Investigating the role of the subjective effects of psychedelics in persisting therapeutic effects

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Katherine M. Nautiyal & David B. Yaden

Probing long-term potentiation-like visual cortical plasticity in humans using repeated visual stimulation: effects on visual evoked potentials

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Holly K. Hamilton & Daniel H. Mathalon

Neuroimaging of plasticity mechanisms in the human brain: from critical periods to psychiatric conditions

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Valerie J. Sydnor & Theodore D. Satterthwaite

N6-methyladenosine (m6A) epitranscriptomics in synaptic plasticity and behaviors

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Emir Malovic & Subhash C. Pandey

Plasticity markers in the human brain associated with rapid antidepressants

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Joshua S. Siegel & Ginger E. Nicol

The role of racial discrimination in dissociation and interoceptive dysfunction

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Negar Fani & Sahib S. Khalsa

Sleep disturbance in substance use disorders: the orexin (hypocretin) system as an emerging pharmacological target

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Utsav Gyawali & Morgan H. James

The double-edged sword of the double-stranded break

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Robert J. Fenster & Junghyup Suh

Beyond the hypothalamus: roles for insulin as a regulator of neurotransmission, motivation, and feeding

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Carrie R. Ferrario & Julie E. Finnell

Unexpected circuit-level tradeoffs in human stress resilience

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Jennifer S. Stevens & Alyssa R. Roeckner

Echoes of ancient DNA in living modern humans affect risk for neuropsychiatric disease and brain structure and function of networks subserving higher-order cognition

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Michael D. Gregory & Karen F. Berman

Real-time fMRI neurofeedback: the promising potential of brain-training technology to advance clinical neuroscience

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Stephan F. Taylor & Meghan E. Martz

Shaping long-range functional connectivity through prefrontal interneuron plasticity

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David A. Kupferschmidt & Joshua A. Gordon

Single-cell transcriptional profiling in brain reward structures

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Jeremy J. Day & Keri Martinowich

Blood-based biomarkers for suicide in depression: moving a step closer to prediction

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Firoza Mamdani & Adolfo Sequeira

Epigenetic aging in psychiatry: clinical implications and therapeutic opportunities

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Camila N. C. Lima & Gabriel R. Fries

How much is too much? New evidence associating low levels of prenatal alcohol exposure with brain differences in children

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Catherine Lebel & Xiangyu Long

Reaching for the unreachable: low intensity focused ultrasound for non-invasive deep brain stimulation

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Noah S. Philip & Amanda R. Arulpragasam

Targeted and transient opening of the blood brain barrier in discrete neurocircuits and brain regions

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Nicole A. Crowley & Scott H. Medina

The promise of 3,4-methylenedioxymethamphetamine (MDMA) in combination with prolonged exposure therapy for posttraumatic stress disorder

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Barbara O. Rothbaum & Jessica L. Maples-Keller

Synaptic plasticity of the orbitofrontal cortex in obesity

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Lauren T. Seabrook & Stephanie L. Borgland