Huntington’s Disease / Table 2

Table 2.

Similarities between Huntington’s disease, excitotoxic lesions and mitochondria toxin lesions

Huntington’s Disease	NMDA Toxicity	Complex II Inhibition
Chorea	Dopamine agonists produce chorea	Dopamine agonists produce chorea
Dementia	Learning difficulties	Learning difficulties
Sparing of striatal cholinergic interneurons	Sparing of striatal cholinergic interneurons	Sparing of striatal cholinergic interneurons
Sparing of NADPH/diaphorase-positive interneurons	Sparing of NADPH/diaphorase-positive interneurons	Sparing of NADPH/diaphorase-positive interneurons
Reduction of striatal GABA	Reduction of striatal GABA	Reduction of striatal GABA