TABLE 2. Glucose metabolism in AD patients of different dementia severity, in relation to metabolism in age-matched healthy controls a

 

rCMRglc (mg/100 g/min)

 

Region

Controls

( N = 30 )

Mild AD

( N = 17 )

Moderate AD

( N = 19 )

Severe AD

( N = 11 )

Association neocortex

 

 

 

 

Prefrontal

7.96 ± 1.09

6.59 ± 1.34 !popup(ch132ref83)c

6.22 ± 1.40 (78)c

4.69 ± 1.64 (59)c

Premotor

8.69 ± 1.16

6.90 ± 1.46 c

6.26 ± 1.43 (72)c

4.70 ± 1.74 (54)c

Parietal

8.27 ± 1.13

6.09 ± 1.37 (74)c

5.36 ± 1.28 (65)c

3.83 ± 1.46 (46)c

Temporal

7.53 ± 0.79

5.98 ± 0.91

5.63 ± 1.23 (75)c

3.97 ± 1.28 (52)c

Occipital

7.72 ± 0.94

6.65 ± 1.28 c

 6.13 ± 1.23 c

5.00 ± 1.83 (65)c

 

 

 

 

 

Primary neocortex

 

 

 

 

Sensorimotor

8.31 ± 1.00

7.27 ± 1.03 c

6.75 ± 1.14 c

5.61 ± 1.71 (68))c

Calcarine

8.06 ± 1.12

7.02 ± 1.09 c

7.09 ± 1.02 c

6.52 ± 1.89 c

 

 

 

 

 

Subcortical nuclei

 

 

 

 

Caudate

9.24 ± 1.64

8.35 ± 1.26

7.72 ± 1.87 c

5.45 ± 1.21 (70)c

Lenticular

9.41 ± 1.37

8.76 ± 1.45

8.71 ± 1.85 c

6.87 ± 1.48 (73)c

Thalamus

8.99 ± 1.37

8.27 ± 1.46

8.15 ± 0.94 c

6.42 ± 2.05 (71)c

a From ref. 45.
b Mean ± SD (percent of  control mean).
c Differs significantly from control mean (p < 0.05), corrected for six comparisons.
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published 2000