Processes Underlying Sleep Regulation

Alexander A. Borbély, Peter Achermann, Beat Geering, and Irene Tobler
Institute of Pharmacology,
University of Zürich
Zürich, Switzerland


Alexander A. Borbély, M.D.
Institute of Pharmacology
University of Zurich
190 CH-8057
Zürich Switzerland

voice 411-257-5960
fax 411-257-5707

For an update of the author’s most recent literature references and information on a CD-ROM on sleep research see http:\\\phar\sleep.


1. Achermann P, Borbély AA. Simulation of human sleep: ultradian dynamics of electroencephalographic slow-wave activity. J Biol Rhythms 1990;5:141-157.

2. Achermann P, Borbély AA. A composite model of sleep regulation: parameter estimation of the homeostatic "module". Proc Ann Int Conf IEEE Eng Med Biol Soc 1992;14: 2624-2625.

3. Achermann P, Borbély AA. Combining various models of sleep regulation. J Sleep Res 1992;1:144-147.

4. Achermann P, Borbély AA. Simulation of daytime vigilance by the additive interaction of a homeostatic and a circadian process. Biol Cybern 1994;71:115-121.

5. Acherman P, Borbély AA. Low-frequency (< 1 H2) oscillations in the human sleep electroencephalogram. Neurosci 1997; 81: 213-222

5a. Achermann P, Borbély AA. Coherence analysis of the human sleep EEG. Neurosci 1998;in press

5b. Acherman P, Borbély AA. Temporal evolution of coherence and power in the human sleep EEG., J Sleep Res; in press

6. Achermann P, Dijk DJ, Brunner DP, Borbély AA. A model of human sleep homeostasis based on EEG slow-wave activity: quantitative comparison of data and simulations. Brain Res Bull 1993;31:97-113.

7. Aeschbach D, Borbély AA. All-night dynamics of the human sleep EEG. J Sleep Res 1993;2:70-81.

8. Aeschbach D, Cajochen C, Landolt HP, Borbély AA. Sleep regulation in habitual short sleepers and long sleepers. Am J Physiol 1996;39:R41-R53.

9. Åkerstedt T, Fröberg JE. Psychophysiological circadian rhythms in women during 72 h of sleep deprivation. Waking and Sleeping 1977;1:387-394.

10. Åkerstedt T, Gillberg M. The circadian variation of experimentally displaced sleep. Sleep 1981;4:159-169.

11. Åkerstedt T, Folkard S. Validation of the S and C components of the three-process model of alertness regulation. Sleep 1995;18:1-6.

12. Åkerstedt T, Folkard S. Predicting sleep latency from the three-process model of alertness regulation. Psychophysiol 1996;33:385-389.

13. Åkerstedt T, Folkard S. Predicting duration of sleep from the three process model of regulation of alertness. Occup Environ Med 1996;53:136-141.

13a. Amzica F. Steriade M. The K-complex-Its (< 1-Hz) rhythmicity and relation to delta waves. Neurology 1997; 49: 952-959

14. Aschoff J. Circadian rhythms in man. Science 1965;148:1427-1432.

15. Aschoff J, Gerecke U, Wever R. Desynchronization of human circadian rhythms. Jap J Physiol 1967;17:450-457.

16. Beersma DGM, Daan S, Dijk DJ. Sleep intensity and timing—A model for their circadian control. Lectures on mathematics in the life sciences 1987;19:39-62.

17. Beersma DGM, Dijk DJ, Blok CGH, Everhardus I. REM sleep deprivation during 5 hours leads to an intermediate REM sleep rebound and to suppression of non-REM sleep intensity. Electroencephalogr Clin Neurophysiol 1990;76:114-122.

18. Benington JH, Heller HC. Restoration of brain energy metabolism as the function of sleep. Prog Neurobiol 1995;45:347-360.

19. Berger RJ, Oswald I . Effects of sleep deprivation on behavior, subsequent sleep, and dreaming. J Mental Sci 1962;108:457-465.

20. Blake H, Gerard RW: Brain potentials during sleep. Am J Physiol 1937;119:692-703.

21. Borbély AA. Effects of light and circadian rhythm on the occurrence of REM sleep in the rat. Sleep 1980;2:289-298.

22. Borbély AA. A two process model of sleep regulation. Human Neurobiol 1982;1:195-204.

23. Borbély AA. Sleep regulation: Circadian rhythm and homeostasis. In: Ganten D, Pfaff D, eds. Sleep. Clinical and experimental aspects. Current topics in neuroendocrinology. New York, Berlin, Heidelberg: Springer-Verlag, 1982;1:83-103.

24. Borbély AA. Sleep homeostasis and models of sleep regulation. In: Kryger MH, Roth T, Dement WC, eds. Principles and practice of sleep medicine. 2nd ed. Philadelphia: Saunders, 1994;309-320.

25. Borbély AA, Neuhaus HU. Sleep-deprivation: Effects on sleep and EEG in the rat. J Comp Physiol 1979;133:71-87.

26. Borbély AA, Achermann P. Concepts and models of sleep regulation, an overview. J Sleep Res 1992;1:63-79.

27. Borbély AA, Tobler I. Endogenous sleep-promoting substances and sleep regulation. Physiol Rev 1989;69:605-670.

28. Borbély AA, Baumann F, Brandeis D, Strauch I, Lehmann D. Sleep-deprivation: Effect on sleep stages and EEG power density in man. Electroencephalogr Clin Neurophysiol 1981;51:483-493.

29. Borbély AA, Loepfe M, Mattmann P, Tobler I. Midazolam and triazolam: hypnotic action and residual effects after a single bedtime dose. Arzneimittel-Forsch/Drug Res 1983;33:1500-1502.

30. Borbély AA, Tobler I, Hanagasioglu M. Effect of sleep deprivation on sleep and EEG power spectra in the rat. Behav Brain Res 1984;14:171-182.

31. Borbély AA, Mattmann P, Loepfe M, Strauch I, Lehmann D. Effect of benzodiazepine hypnotics on all-night sleep EEG spectra. Hum Neurobiol 1985;4:189-194.

32. Borbély AA, Achermann P, Trachsel L, Tobler I. Sleep initiation and sleep intensity: interaction of homeostatic and circadian mechanisms. J Biol Rhythms 1989;4:149-160.

33. Brunner DP, Dijk DJ, Tobler I, Borbély AA. Effect of partial sleep deprivation on sleep stages and EEG power spectra: evidence for non-REM and REM sleep homeostasis. Electroencephalogr Clin Neurophysiol 1990;75:492-499.

34. Brunner DP, Dijk DJ, Münch M, Borbély AA. Effect of zolpidem on sleep and sleep EEG spectra in healthy young men. Psychopharmacol 1991;104:1-5.

35. Brunner DP, Dijk DJ, Borbély AA. Repeated partial sleep deprivation progressively changes the EEG during sleep and wakefulness. Sleep 1993;16:100-113.

36. Buchsbaum MS, Mendelson WB, Duncan WC, Coppola R, Kelsoe J, Gillin JC. Topographic cortical mapping of EEG sleep stages during daytime naps in normal subjects. Sleep 1982;5:248-255.

37. Cartwright RD, Monroe LJ, Palmer C. Individual differences in response to REM deprivation. Arch Gen Psychiatry 1967;16:297-303.

38. Church MW, March JD, Hibi S, Cavness C, Feinberg I. Changes in frequency and amplitude of delta activity during sleep. Electroencephalogr Clin Neurophysiol 1975;39:1-7.

39. Cirelli C, Pompeiano M, Tononi G. Sleep deprivation and c-fos expression in the rat brain. J Sleep Res 1995;4:92-106.

40. Cirelli C, Pompeiano M, Tononi G. Neuronal gene expression in the waking state: a role for the locus coeruleus. Science 1996;274:1211-1215.

41. Cooley WJ, Tukey JW. An algorithm for the machine calculation of complex Fourier series. Math Comput 1965;19:297-301.

42. Czeisler CA. Human circadian physiology: internal organization of temperature, sleep-wake and neuroendocrine rhythms monitored in an environment free of time cues. Ph. D. Dissertation, Stanford University, 1978.

43. Czeisler CA, Zimmerman JC, Ronda JM, Moore-Ede MC, Weitzman ED. Timing of REM sleep is coupled to the circadian rhythm of body temperature in man. Sleep 1980;2:329-346.

44. Czeisler CA, Weitzman ED, Moore-Ede MC, Zimmerman JC, Kronauer RS. Human sleep: Its duration and organization depend on its circadian phase. Science 1980;210:1264-1267.

45. Czeisler CA, Duffy JF, Shanahan TL, Brown EN, Mitchell JF, Dijk DJ, Rimmer DW, Ronda JM, Allan JS, Emens JS, Kronauer RE. Reassessment of the intrinsic period of the human circadian pacemaker in young and older subjects. Sleep Res 1995;24A:505.

46. Daan S, Beersma DGM. Circadian gating of human sleep-wake cycles. In: Moore-Ede MC, Czeisler CA, eds. Mathematical models of the circadian sleep-wake cycle. New York: Raven Press, 1984;129-158.

47. Daan S, Beersma DGM, Borbély AA. Timing of human sleep: Recovery process gated by a circadian pacemaker. Am J Physiol 1984;246:R161-R178.

48. Daan S, Beersma DGM, Dijk DJ, aNkerstedt T, Gillberg M: Kinetics of an hourglass component involved in the regulation of human sleep and wakefulness. In: Hekkens WTJM, Kerkhof GA, Rietveld WJ, eds. Advances in the bio-sciences, trends in chronobiology. Oxford; Pergamon Press, 1988;73:183-193.

49. Deboer T, Tobler I. Vigilance state episodes and cortical temperature in the Djungarian hamster: the influence of photoperiod and ambient temperature. Pflügers Arch 1996;433:230-237.

50. Dement WC. The effects of dream deprivation. Science 1960;131:1705-1707.

51. Dijk DJ, Czeisler CA. Body temperature is elevated during the rebound of slow wave sleep following 40-h of sleep deprivation on a constant routine. J Sleep Res 1993;2:117-120.

52. Dijk DJ, Czeisler CA. Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans. Neurosci Lett 1994;166:63-68.

53. Dijk DJ, Czeisler CA. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure and electroencephalographic slow waves and sleep spindle activity in humans. J Neurosci 1995;15:3526-3538.

54. Dijk DJ, Beersma DGM, Daan S: EEG power density during nap sleep: reflection of an hourglass measuring the duration of prior wakefulness. J Biol Rhythms 1987;2:207-219.

55. Dijk DJ, Beersma DGM, Daan S, Bloem GM, van den Hoofdakker RH. Quantitative analysis of the effects of slow-wave sleep deprivation during the first 3 h of sleep on subsequent EEG power density. Eur Arch Psychiatr Neurol Sci 1987;236:323-328.

56. Dijk DJ, Beersma DGM, Daan S. Bright morning light advances the human circadian system without affecting NREM sleep homeostasis. Am J Physiol 1989;256:R106-R111.

57. Dijk DJ, Brunner D, Borbély AA. Time course of EEG power density during long sleep in humans. Am J Physiol 1990;258:R650-R661.

58. Dijk DJ, Brunner DP, Beersma DGM, Borbély AA. Electroencephalogram power density and slow wave sleep as a function of prior waking and circadian phase. Sleep 1990;13:430-440.

59. Dijk DJ, Brunner DP, Borbély AA. EEG power density during recovery sleep in the morning. Electroencephalogr Clin Neurophysiol 1991;78:203-214.

60. Dijk DJ, Cajochen C, Tobler I, Borbély AA. Sleep extension in humans: sleep stages, EEG power spectra, and body temperature. Sleep 1991;14:294-306.

61. Dijk D J, Hayes B, Czeisler C A. Dynamics of electroencephalographic sleep spindles and slow wave activity in men: effect of sleep deprivation. Brain Res 1993;626:190-199.

61a. Dijk D J, Shanahan TL, Duffy JF, Ronda JM, Czeisler CA. Variation of electroencephalographic activity during non-rapid eyemovement and rapid eye movement sleep with phase of circadian melatonin rhythm in humans. J Physiol 1997; 505: 851-858

62. Edgar DM, Dement WC, Fuller CA. Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation. J Neurosci 1993;13:1065-1079.

63. Endo T, Roth C, Landolt HP, Werth E, Aeschbach D, Achermann P, Borbély AA. Selective REM sleep deprivation in humans: effects on sleep and sleep EEG. Am J Physiol 1998;274: R1186-R1194.

64. Feinberg I. Changes in sleep cycle patterns with age. J Psychiatry Res 1974;10:283-306.

65. Feinberg I, March JD, Fein G, Floyd TC, Walker JM, Price L. Period and amplitude analysis of 0.5-3 Hz activity in NREM sleep of young adults. Electroencephalogr Clin Neurophysiol 1978;44:202-213.

66. Feinberg I, March JD, Floyd TC, Jimison R, Bossom-Demitrack L, Katz PH. Homeostatic changes during post-nap sleep maintain baseline levels of delta EEG. Electroencephalogr Clin Neurophysiol 1985;61:134-137.

67. Feinberg I, Maloney T, March JD. Precise conservation of nonREM Period 1 (nonREMP1) delta across naps and nocturnal sleep: Implications for REM latency and nonREM/REM alternation. Sleep 1992;15:400-403.

68. Folkard S, Åkerstedt T. Towards a model for the prediction of alertness and/or fatigue on different sleep/wake schedules. In: Oginski A, Polorski J, Rutenfranz J, eds. Contemporary advances in shiftwork research: Theoretical and practical aspects in the late eighties. Medical Academy, Krakow, Poland, 1987;231-240.

69. Folkard S, Åkerstedt T. A three-process model of the regulation of alertness-sleepiness. In: Broughton RJ, Ogilvie RD, eds. Sleep, arousal, and performance. Boston, Basel, Berlin: Birkhäuser, 1992;11-26.

70. Franken P, Dijk DJ, Tobler I, Borbély AA. Sleep deprivation in the rat: effects of electroencephalogram power spectra, vigilance states, and cortical temperature. Am J Physiol 1991;261:R198-R208.

71. Franken P, Tobler I, Borbély AA. Sleep homeostasis in the rat: simulation of the time course of EEG slow-wave activity. Neurosci Lett 1991;130:141-144.

72. Franken P, Tobler I, Borbély AA. Varying the photoperiod in the laboratory rat: profound effect on the 24-h sleep pattern but no effect on sleep homeostasis. Am J Physiol 1995;269:R691-R701.

73. Geering BA, Achermann P, Eggimann F, Borbély AA. Period-amplitude and power spectral analysis: a comparison based on all-night sleep EEG recordings. J Sleep Res 1993;2:121-129.

74. Hayaishi O, Matsumura H. Prostaglandins and sleep. Adv Neuroimmunol 1995;5:211-216.

75. Hirsch JC, Fourment A, Marc ME. Sleep-related variations of membrane potential in the lateral geniculate body relay neurons of the cat. Brain Res 1983;259:308-312.

76. Horne JA. Human sleep, sleep loss and behaviour: implications for the prefrontal cortex and psychiatric disorder. Br J Psychiatry 1993;162:413-419.

77. Inoue S, Honda K, Komoda Y. Sleep as neuronal detoxification and restitution. Behav Brain Res 1995;69:91-96.

78. Ishimori K. True cause of sleep—A hypnogenic substance as evidenced in the brain of sleep-deprived animals. Tokyo Igakkai Zasshi 1909;23:423-457.

79. Kales A., Hoedemaker FS, Jacobson A., Lichtenstein EL. Dream deprivation: an experimental reappraisal. Nature 1964;204:1337-1338.

80. Kaiser W. Busy bees need rest, too. J Comp Physiol 1988;=+A163:565-584.

81. Kaiser W, Steiner-Kaiser J. Neuronal correlates of sleep, wakefulness and arousal in a diurnal insect. Nature 1983;301:707-709.

82. Karacan I, Williams RL, Finley WW, Hursch CJ. The effects of naps on nocturnal sleep: Influence on the need for stage 1-REM and stage 4 sleep. Biol Psychiatry 1970;2:391-399.

83. Kattler H, Dijk DJ, Borbély AA. Effect of unilateral somatosensory stimulation prior to sleep on the sleep EEG in humans. J Sleep Res 1994;3:159-164.

84. Kecklund G, Åkerstedt T. The pattern of slow wave activity in spontaneously occurring long sleep. J Sleep Res 1992;1:30-34.

85. Knowles JB, MacLean AW, Salem L, Vetere C, Coutler M. Slow-wave sleep in daytime and nocturnal sleep: an estimation of the time course of 'Process S'. J Biol Rhythms 1986;1:303-308.

86. Knowles JB, Coulter M, Wahnon S, Reitz W, Maclean AW. Variations in process S: effects on sleep continuity and architecture. Sleep 1990;13:97-107.

87. Knowles JB, Maclean AW, Brunet D, Coulter M. Nap-induced changes in the time course of Process S. Effects on nocturnal slow wave activity. In: Horne JA, ed. Sleep '90. Bochum: Pontenagel Press, 1990;68-70.

88. Krueger JM, Obál F. A neuronal group theory of sleep function. J Sleep Res 1993;2:63-69.

89. Krueger JM, Takahashi S, Kapas L, Bredow S, Roky R, Fang J, Floyd R, Renegar KB, Guha-Thakurta N, Novitzky S. Cytokines in sleep regulation. Adv Neuroimmunol 1995;5:171-188

90. Ktonas PY. Editorial comment: period-amplitude EEG analysis. Sleep 1987;10:505-507.

91. Maquet P, Péters JM, Aerts J, Delfiore G, Degueldre C, Luxen A, Franck G. Functional neuroanatomy of human rapid-eye-movement sleep and dreaming. Nature 1996;383:163-166.

92. Maron L, Rechtschaffen A, Wolpert EA. Sleep cycle during napping. Arch Gen Psychiatry 1964;11:503-507.

93. Massaquoi S, McCarley RW. Extension of the limit cycle reciprocal interaction model of REM cycle control: an integrated sleep control model. J Sleep Res 1992;1:132-137.

94. Mistlberger R, Bergmann B, Waldenar W, Rechtschaffen A. Recovery sleep following sleep deprivation in intact and suprachiasmatic nuclei lesioned rats. Sleep 1983;6:217-233.

95. Mistlberger R, Bergmann B, Rechtschaffen A. Period-amplitude analysis of rat electroencephalogram: effects of sleep deprivation and exercise. Sleep 1987;10:508-522.

96. Mukhametov LM. Sleep in marine mammals. Exp Brain Res 1984;8:227-236.

97. Neuner-Jehle M, Rhyner TA, Borbély AA. Sleep deprivation differentially alters the mRNA and protein levels of neurogranin in rat brain. Brain Res 1995;685:143-153.

98. Neuner-Jehle M, Denizot JP, Borbély AA, Mallet J. Characterization and sleep deprivation-induced expression modulation of dendrin, a novel dendritic protein in rat brain neurons. J Neurosci Res 1996;46:138-151.

99. Oleksenko AI, Mukhametov LM, Polyakova IG, Supin AY, Kovalzon VM. Unihemispheric sleep deprivation in bottlenose dolphins. J Sleep Res 1992;1:40-44.

100. Piéron H. Le problème physiologique du sommeil. Paris: Masson, 1913.

101. Rechtschaffen A, Kales A, eds. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Bethesda, MD: US Department of Health, Education and Welfare, 1968.

102. Rhyner TA, Borbély AA, Mallet J. Molecular cloning of forebrain mRNAs modulated by sleep deprivation. Eur J Neurosci 1990;2:1063-1073.

103. Satoh S, Matsumura H, Suzuki F, Hayaishi O. Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in rats. Proc Natl Acad Sci USA 1996;93:5980-5984.

104. Sherin JE, Shiromani PJ, McCarley RW, Saper CB. Activation of ventrolateral preoptic neurons during sleep. Science 1996;271:216-219.

105. Skaggs WE, McNaughton BL. Replay of neuronal firing sequences in rat hippocampus during sleep following spatial experience. Science 1996;271:1870-1873.

106. Steriade M., McCormick DA, Sejnowski TJ. Thalamocortical oscillations in the sleeping and aroused brain. Science 1993;262:679-685.

106a. Steriade M, Nuñez A, Amzica F. A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components. J Neurosci 1993; 12: 3252-3265

107. Steriade M, Contreras D, Amzica F. Synchronized sleep oscillations and their paroxysmal developments. TINS 1994;17:199-208.

108. Strogatz SH, Kronauer RE, Czeisler CA. Circadian regulation dominates homeostatic control of sleep length and prior wake length in humans. Sleep 1986;9:353-364.

109. Tobler I. Effect of forced locomotion on the rest-activity cycle of the cockroach. Behav Brain Res 1983;8:351-360.

110. Tobler I. Is sleep fundamentally different between mammalian species? In: Giuditta A. ed. Behav Brain Res: The function of sleep, Elsevier, 1995;69:35-41.

111. Tobler I, Borbély AA. Sleep EEG in the rat as a function of prior waking. Electroencephalogr Clin Neurophysiol 1986;64:74-76.

112. Tobler I, Stalder J. Rest in the scorpion-A sleep-like state? J Comp Physiol 1988;=+A163:227-235.

113. Tobler I, Borbély AA. The effect of 3-h and 6-h sleep deprivation on sleep and EEG spectra of the rat. Behav Brain Res 1990;36:73-78.

114. Tobler I, Neuner-Jehle M. 24-h variation of vigilance in the cockroach Blaberus giganteus. J Sleep Res 1992;1:231-239.

115. Tobler I, Borbély AA, Groos G. The effect of sleep deprivation on sleep in rats with suprachiasmatic lesions. Neurosci Lett 1983;42:49-54.

116. Tobler I, Gaus SE, Deboer T, Achermann P, Fischer M, Rülicke T, Moser B, Oesch B, McBride PA, Manson JC. Altered circadian activity rhythms and sleep in mice devoid of prion protein. Nature 1996;380:639-642.

117. Tobler I, Deboer T, Fischer M. Sleep and sleep regulation in normal and prion protein deficient mice. J Neurosci, 1997;17: 1869-1879

118. Tononi G, Cirelli C, Pompeiano M. Changes in gene expression during the sleep-waking cycle: a new view of activating systems. Arch Ital Biol 1995;134:21-37.

118a. Tononi C, Cirellic. Changes in the expression of mitochondrial genes during the sleep-walking cycle. Society for neuroscience Abstacts 1997;1846.

119. Trachsel L, Tobler I, Borbély AA. Sleep regulation in rats: Effects of sleep deprivation, light, and circadian phase. Am J Physiol 1986;251:R1037-R1044.

120. Trachsel L, Dijk DJ, Brunner D, Klene C, Borbély AA. Effect of zopiclone and midazolam on sleep and EEG spectra in a phase-advanced sleep schedule. Neuropsychopharmacol 1990;3:11-18.

121. Trachsel L, Edgar DM, Wesley FS, Heller HC, Dement WC. Sleep homeostasis in suprachiasmatic nuclei-lesioned rats: effects of sleep deprivation and triazolam administration. Brain Res 1992;589:253-261.

122. Webb WB, Agnew HW Jr. Stage 4 sleep: Influence of time course variables. Science 1971;174:1354-1356.

123. Werth E, Dijk DJ, Achermann P, Borbély AA. Dynamics of the sleep EEG after an early evening nap: Experimental data and simulations. Am J Physiol 1996;271:R501-R510.

124. Werth E, Achermann P, Borbély AA. Brain topography of the human sleep EEG: antero-posterior shifts of spectral power. Neuroreport 1996;8:123-127.

124a. Werth E, Achermann P, Borbély AA. Fronto-occipital EEG power gradients in human sleep Res 1997;6:102-112

125. Wever RA. The circadian system of man. Results of experiments under temporal isolation. New York: Springer-Verlag, 1979.

126. Williams HL, Hammack JT, Daly RL, Dement WC, Lubin A. Responses to auditory stimulation, sleep loss and the EEG stages of sleep. Electroencephalogr Clin Neurophysiol 1964;16:269-279.

127. Zeitlhofer J, Anderer P, Obergottsberger S, Schimicek P, Lurger S, Marschnigg E, Saletu B, Deecke L. Topographic mapping of EEG during sleep. Brain Topogr 1993;6:123-129.

128. Zulley J. Der einfluss von zeitgebern auf den schlaf des menschen. Frankfurt: Fischer, 1979.

129. Zulley J, Wever R, Aschoff J. The dependence of onset and duration of sleep on the circadian rhythm of rectal temperature. Pflügers Arch 1981;391:314-318.

130. Zulley J, Wever RA. Interaction between the sleep-wake cycle and the rhythm of rectal temperature. In: Aschoff J, Daan S, Groos G, eds. Vertebrate circadian systems: structure and physiology. Berlin, Heidelberg, New York: Springer, 1982;253-261.
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published 2000