TABLE 1.  Functional classification of proto-oncogenes a

 

Class

Proto-oncogene

nomenclature

 

Homolog

Receptor ligand

c-sis

int-2

hst

PDGF B chain

Basic-FGF-like

FGF-like

Transmembrane tyrosine kinases

c-erbB

c-fms

neu (c-erbB-2)

trk, trkB, trkC

c-met

c-kit

c-ros

c-sea

EGF receptor

CSF -1 receptor

EGF receptor-like

Neurotrophin receptors

Insulin receptor-like

w locus gene

Insulin receptor-like

Insulin receptor-like

Membrane-associated tyrosine kinases

c-src

hck

c-abl

c-yes-1 and-2

c-fgr

c-lck

c-fps/fes

fer

flk

flk

c-syn

c-lyn

c-slk

fyn

 

Nontyrosine kinase receptors

mas

Angiotensin receptor

Serine/threonine kinases

c-raf-1

c-mos

pim-1

 

G-protein-like

c-Ha-ras

c-Ki-ras

c-N-ras

rab (1-4)

ypt-1

rho

smg

 

Signal transduction enzymes

crk

Phospholipase C-like

Nuclear proteins

c-ski

c-erbA

snoA and B

ets-1 and -2

c-myb

mybA and B

 

Thyroid hormone receptor

 

 

Related to NFkB

Zinc finger proteins

gli

gr-1 and -2

Related to krueppel

Related to krueppel

Leucine zipper protein

c-fos

fra-1 and -2

fosB

c-jun, -B, -D

 

AP-1 complexes

 

Helix-loop-helix

c-myc

N-myc

L-myc

 

   a Reproduced with permission from Discussions in Neuroscience, vol. VII, no. 4, August 1991.

Elsevier Science Publishers B.V.

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published 2000