Beyond Second Messengers

James I. Morgan and Thomas E. Curran


1. Abate C, Patel L, Rauscher FJ III, Curran T. Redox regulation of Fos and Jun DNA binding activity in vitro. Science 1990;249:1157–1161.

2. Berreta S, Robertson HA, Graybiel AM. Dopamine and glutamate agonists stimulate neuron-specific expression of Fos-like protein in the striatum. J Neurophysiol 1992;68:767–777.

3. Castro-Alamancos MA, Borrell J, Garcia-Segura LM. Performance in an escape task induces fos-like immunoreactivity in a specific area of the motor cortex of the rat. Neuroscience 1992;49:157–162.

4. Cochran BH, Reffel AC, Stiles CD. Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell 1983; 33:939–947.

5. Curran T, Morgan JI. Memories of Fos. BioEssays 1987;7:255–258.

6. Curran T, Morgan JI. Superinduction of fos by nerve growth factor in the presence of peripherally active benzodiazepines. Science 1985;229:1265–1268.

7. Curran T, Franza BR Jr. Fos and Jun: the AP-1 connection. Cell 1988;55:395–397.

8. Demmer J, Dragunow M, Lawlor PA, et al. Differential expression of immediate early genes after hippocampal long-term potentiation in awake rats. Mol Brain Res 1993;17:279–286.

9. Dragunow M, Faull R. The use of c-fos as a metabolic marker in neuronal pathway tracing. J Neurosci Meth 1989;29:261–265.

10. Dragunow M, Robertson HA. Kindling stimulation induces c-fos protein(s) in granule cells of the dentate gyrus. Nature 1987; 329:441–442.

11. Greenberg ME, Greene LA, Ziff EB. Nerve growth factor and epidermal growth factor induce rapid transient changes in protooncogene transcription in PC12 cells. J Biol Chem 1985;260: 14101–14110.

12. Greenberg ME, Ziff EB. Stimulation of 3T3 cells induces transcription of the fos proto-oncogene. Nature 1984;311:433–438.

13. Gubits RM, Burke RE, Casey-MacIntosh G, Bandele A, Munell F. Immediate-early gene induction after neonatal hypoxia-ischemia. Mol Brain Res 1993;18:228–238.

14. Gunn AJ, Dragunow M, Faull RLM, Gluckman PD. Effects of hypoxia-ischemia and seizures on neuronal and glial-like c-fos protein levels in the infant rat. Brain Res 1990;531:105–116.

15. Hai T, Curran T. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci USA 1991;88:1–5.

16. Herdegen T, Fiallos-Estrada CE, Schmid W, Bravo R, Zimmermann M. The transcription factors c-JUN, JUN D and CREB, but not FOS and KROX-24, are differentially regulated in axotomized neurons following transection of rat sciatic nerve. Mol Brain Res 1992; 14:155–165.

17. Hilbush BS, Curran T, Morgan JI. (1994) Cellular immediate-early genes in the nervous system: genes for all reasons? In: Fuxe K, Leon A, Ottoson D, eds. Trophic regulation in the basal ganglia. Focus on dopamine neurons. New York: Pergamon Press, 1994;[in press].

18. Hughes P, Dragunow M. Muscarinic receptor-mediated induction of FOS protein in rat brain. Neurosci Lett 1993;150:122–126.

19. Hunt SP, Pini A, Evan G. Induction of c-fos like protein in spinal cord neurons following sensory stimulation. Nature 1987;328:632–634.

20. Jenkins R, Hunt SP. Long term increase in the levels of c-jun mRNA and Jun protein-like immunoreactivity in motor and sensory neurons following axon damage. Neurosci Lett 1991;129:107–110.

21. Jorgenson M, Deckert J, Wright D, Gehlert D. Delayed c-fos proto-oncogene expression in the rat hippocampus induced by transient global cerebral ischemia: an in situ hybridization study. Brain Res 1989;484:393–398.

22. Keissling M, Stumm P, Xie Y, Gass P. Differential transcription and translation of immediate-early genes after global ischaemia in gerbil brain. J Cereb Blood Flow 1993;13(Suppl 1):S465.

23. Kerppola T, Curran T. Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity. Cell 1992;66:317–326.

24. Kerppola T, Curran T. Transcription factor interactions: basics on zippers. Curr Opin Struct Biol 1991;1:71–79.

25. Landshultz WH, Johnson PF, McKnight SL. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 1988;240:1759–1764.

26. Lau LF, Nathans D. Expression of a set of growth-related immediate-early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc. Proc Natl Acad Sci USA 1987;84:1182–1186.

27. Lau LF, Nathans D. Identification of a set of genes expressed during the Go/G1 transition of cultured mouse cells. EMBO J 1985; 4:3145–3151.

28. Molinar-Rode R, Smeyne RJ, Curran T, Morgan JI. Regulation of proto-oncogene expression in adult and developing lungs. Mol Cell Biol 1993;13:3213–3220.

29. Morgan JI, Cohen DR, Hempstead JL, Curran T. Mapping patterns of c-fos expression in the central nervous system after seizure. Science 1987;237:192–197.

30. Morgan JI, Curran T. Stimulus-transcription coupling in neurons: role of cellular immediate-early genes. Trends Neurosci 1989; 12:259–462.

31. Morgan JI, Curran T. Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu Rev Neurosci 1991;14:421–451.

32. Morgan JI, Curran T. The role of ion flux in the control of c-fos expression. Nature 1986;322:552–555.

33. Morgan JI, Curran T. Calcium as a modulator of the immediate-early gene cascade in neurons. Cell Calcium 1988;9:303–311.

34. Morgan JI. Proto-oncogene expression in the nervous system. (vol. 7). Magistretti JP, ed; Discussion in neuroscience, FESN; Amsterdam: Elsevier; 1991.

35. Mugnaini E, Berrebi A, Morgan JI, Curran T. fos-like immunoreactivity induced by seizure is specifically associated with euchromatin in neurons. Eur J Neurosci 1989;1:46–52.

36. Muller R, Bravo R, Burckhardt J, Curran T. Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature 1984;312:716–720.

37. Rauscher FJ III, Sambucetti LC, Curran T, Distel RJ, Spiegelman BM. A common DNA binding site for Fos protein complexes and transcription factor AP-1. Cell 1988;52:471–480.

38. Rea MA. Light increases Fos-related protein immunoreactivity in the rat suprachiasmatic nuclei. Brain Res Bull 1989;23:577–581.

39. Ren T, Sagar SM. Induction of c-fos immunostaining in the rat brain after systemic administration of nicotine. Brain Res Bull 1992;29:589–597.

40. Richard D, Rivest S, Rivier C. The 5-hydroxytryptamine agonist fenfluramine increases Fos-like immunoreactivity in the brain. Brain Res 1992;594:131–137.

41. Sagar SM, Sharp FR, Curran T. Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science 1988;240:1328–1331.

42. Schilling K, Luk D, Morgan JI, Curran T. Regulation of a fos-lacZ fusion gene: a paradigm for quantitative analysis of stimulus-transcription coupling. Proc Natl Acad Sci USA 1991;88:5665–5669.

43. Sheng M, Greenberg ME. The regulation and function of c-fos and other immediate-early genes in the nervous system. Neuron 1990;4:477–485.

44. Smeyne RJ, Curran T, Morgan JI. Temporal and spatial expression of a fos-lacZ transgene in the developing nervous system. Mol Brain Res 1992;16:158–162.

45. Smeyne RJ, Schilling K, Robertson L, et al. Fos-lacZ transgenic mice: mapping sites of gene induction in the central nervous system. Neuron 1992;8:13–23.

46. Smeyne RJ, Vendrell M, Hayward M, et al. Continuous c-fos expression precedes programmed cell death in vivo. Nature 1993;363:166–169.

47. Sonnenberg JL, Macgregor-Leon PF, Curran T, Morgan JI. Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure. Neuron 1989;3:359–365.

48. Sonnenberg JL, Mitchelmore C, Macgregor-Leon PF, Hempstead JL, Morgan JI, Curran T. Glutamate receptor agonists increase the expression of Fos, Fra and AP-1 DNA binding activity in the mammalian brain. J Neurosci Res 1989;24:72–80.

49. Sonnenberg JL, Rauscher FJ III, Morgan JI, Curran T. Regulation of proenkephalin by proto-oncogenes fos and jun. Science 1989; 246:1622–1625.

50. Tsujino J, Sano H, Kubota Y, et al. Expression of FOS-like immunoreactivity by yohimbine and clonidine in the rat brain. Eur J Pharmacol 1992;226:69–78.

51. Xanthoudakis S, Miao G, Feng W, Pan Y-CE, Curran T. Redox activation of Fos–Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J 1992;11:3323–3335.


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published 2000