Figure 3.
Effects of 6-OHDA-induced depletion of tissue DA in striatum on extracellular DA. The data were organized a posterior into the following groups: intact (open bars; n = 13), 1080% tissue DA depletion (solid bars; n = 7), and >80% tissue DA depletion (hatched bars; n = 12). A: The absolute amount of DA obtained in striatal dialysates was not significantly affected unless tissue DA level in striatum was decreased by more than 80%. B: Because dialysate DA level was decreased by a lesser amount than was tissue DA level, the ratio of these two measures increased with increasing lesion size. This ratio is an estimate of the contribution of each surviving DA terminal to the pool of extracellular DA. Results are expressed as mean SEM; *, p < 0.05 versus intact. (From ref. 56.)
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published 2000