Risk to offspring
Father-to-son transmission
Father-to daughter transmission
Disease expression
Affected generations
Autosomal dominant
50%
yes
variable
multiple
Autosomal recessive
25%
less variable
one (unless inbreeding)
X-linked recessive
-50% of sons of carrier female are affected
-50% of daughters of carrier female are carriers
-100% of daughters of carrier male are carriers
no
100% of daughters of carrier male are carriers
Multifactorial
risk approximately the square root of the population risk
published 2000