| Figure 6B. |
|
|
| The Hypothesized Abnormalities in CSTC circuitry associated with the TS. We hypothesize that the symptoms of TS and related disorders are the result of a selective disinhibition of subsets of thalamocortical projections. This disinhibition is the product of one or more of mechanisms (dopaminergic hyperinnervation of the striatum, increased D2 receptor sensitivity, reduced activity of the subthalamic nucleus) leading to an imbalance in the direct and indirect pathways (see text and ref. 60). Not depicted in this figure are the important interactions among the sensorimotor, associative, and limbic CSTC circuits. Nor does it present the importance of relative activation of left versus right CSTC circuits or the cerebellar inputs to the thalamus. |
published 2000