FIG. 1

PrP cerebral amyloid plaques develop in the spontaneous neurodegenerative disease of transgenic mice which express a mouse PrP gene mimicking the codon 102 mutation genetically linked to human ataxic GSS, Tg (MoPrP-P102L)-174 mice (Hsiao et al., in preparation). Most of the amyloid plaques were located in the caudate nucleus but also occurred in the hippocampus and cerebellar cortex. A: Multiple amyloid plaques in the caudate nucleus. Bar represents 100 mm. Periodic acid–Schiff stain. B: Amyloid plaques in the caudate nucleus react specifically with PrP antibodies (R073). Peroxidase immunohistochemistry following proteinase K digestion. Bar represents 50 mm.

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published 2000