1. Anderson JP, Esch FS, Keim PS, Sambamurti K, Lieberburg I, Robakis NK. Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells. Neurosci Lett 1991;128:126–128.

2. Beisiegel U, Weber W, Ihrke G, Herz J, Stanley K. The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. Nature 1989;341:162–164.

3. Bendotti C, Forloni G, Morgan R, et al. Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid and lesioned mice. Proc Natl Acad Sci USA 1988;85:3628–3632.

4. Cai X-D, Golde TE, Younkin SG. Release of excess amyloid b protein from a mutant amyloid b protein precursor. Science 1993;259:514–516.

5. Carlsson J, Armstrong V, Reiber H, Felgenhauer K, Seidel D. Clinical relevance of the quantification of apolipoprotein E in cerebrospinal fluid. Clin Chim Acta 1991;196:167–176.

6. Carter DA, Desmarais E, Bellis M, et al. More missense in amyloid gene. Nature Genet 1992;2:255–256.

7. Chartier Harlin MC, Crawford F, Houlden H, et al. Early onset Alzheimer's disease caused by mutations at codon 717 of the b-amyloid precursor protein gene. Nature 1991;353:844–846.

8. Citron M, Oltersdorf T, Haass C, et al. Mutation of the b-amyloid precursor protein in familial Alzheimer's disease increases bprotein production. Nature 1992;360:672–674.

9. Clark R, Goate A. Molecular genetics of Alzheimer's disease. Arch Neurol 1993;50:1164–1172.

10. Coon H, Hoff M, Holik J, et al. C to T nucleotide substitution in codon 713 of amyloid precursor protein gene not found in 86 unrelated schizophrenics from multiplex families. Am J Med Gen (Neuropsychiatr Genet) 1993;48:36–39.

11. Corder E, Saunders A, Strittmatter W, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921–923.

12. Das H, McPherson J, Bruns G, Karathanasis S, Breslow J. Isolation, characterization and mapping to chromosome 19 of the human apolipoprotein E gene. J Biol Chem 1985;260:6240–6247.

13. Delabar JM, Goldgaber D, Lamour Y, et al. Beta amyloid gene duplication in Alzheimer's disease and karyotypically normal Down syndrome. Science 1987;235:1390–1392.

14. Fabian H, Szendrei G, Mantsch H, Otvos L Jr. Comparative analysis of human and Dutch-type Alzheimer beta-amyloid peptides by infrared spectroscopy and circular dichroism. Biochem Biophys Res Commun 1993;191(1):232–239.

15. Felenstein K, Lewis-Higgins L. Processing of the b-amyloid precursor protein carrying the familial, Dutch-type, and a novel recombinant C-terminal mutation. Neurosci Lett 1993;152:185–189.

16. Fidani L, Rooke K, Chartier-Harlin MC, et al. Screening for mutations in the open reading frame and promoter of the b-amyloid precursor protein gene in familial Alzheimer's disease: identification of a further family with APP717 Val{ewc MVIMG, MVIMAGE,!rtarrow.bmp}Ile. Hum Mol Genet 1992;1:165–168.

17. Glenner GG, Wong CW. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984;120:885–890.

18. Goate A, Chartier Harlin MC, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991;349:704–706.

19. Goate AM, Haynes AR, Owen MJ, et al. Predisposing locus for Alzheimer's disease on chromosome 21. Lancet 1989;1:352–355.

20. Haass C, Schlossmacher M, Hung A, et al. Amyloid b-peptide is produced by cultured cells during normal metabolism. Nature 1992;359:322–325.

21. Hendriks L, van Duijn C, Cras P, et al. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the b-amyloid precursor protein gene. Nature Genet 1992;1(3):218–221.

22. Heyman A, Wilkinson WE, Stafford JA, Helms MJ, Sigmon AH, Weinberg T. Alzheimer's disease: a study of epidemiological aspects. Ann Neurol 1984;15:335–341.

23. Jones LM, Knowler JT. Role of ribonuclease and ribonuclease inhibitor activities in Alzheimer's disease. J Neurochem 1989;53: 1341–1344.

24. Kang J, Lemaire HG, Unterbeck A, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987;325:733–736.

25. Levy E, Carman MD, Fernandez Madrid IJ, et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 1990;248:1124–1126.

26. Lin F-H, Lin R, Wisniewski H, et al. Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's disease. Biochem Biophys Res Commun 1992;182: 238–246.

27. Luyendijk W, Bots GT, Vegter Van der Vlis M, Went LN, Frangione B. Hereditary cerebral haemorrhage caused by cortical amyloid angiopathy. J Neurol Sci 1988;85:267–280.

28. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988;240:622–630.

29. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984;34:939–944.

30. Meggendorfer F. Uber familiengeschichtliche Untersuchungen bei arteriosklerotischer und seniler Demenz. Zentralbl Neurol Psychiatr 1925;40:359.

31. Menzel H, Kladetzky R, Assmann G. Apolipoprotein E polymorphism and coronary artery disease. Arteriosclerosis 1983;3:310–315.

32. Mortimer JA, van Duijn CM, Chandra V, et al. Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies. Int J Epidemiol 1991;20(Suppl 2):S28–S35.

33. Mullan M, Crawford F, Axelman K, et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of b-amyloid. Nature Genet 1992;1(4):345–347.

34. Mullan M, Houlden H, Windelspecht M, et al. A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the a1-antichymotrypsin gene. Nature Genet 1992;2:340–342.

35. Murrell J, Farlow M, Ghetti B, Benson M. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 1991;254:97–99.

36. Namba Y, Tomonaga M, Kawasaki H, Otomo E, Ikeda K. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt–Jakob disease. Brain Res 1991;541:163–166.

37. Oliver C, Holland AJ. Down's syndrome and Alzheimer's disease: a review. Psychol Med 1986;16:307–322.

38. Paik Y-K, Chang D, Reardon C, Davies G, Mahley R, Taylor J. Nucleotide sequence and structure of the human apolipoprotein E gene. Proc Natl Acad Sci USA 1985;82:3445–3449.

39. Payami H, Kaye J, Heston L, Bird T, Schellenberg G. Apolipoprotein E genotype and Alzheimer's disease. Lancet 1993;342:738.

40. Pericak-Vance MA, Bebout JL, Gaskell PC Jr, et al. Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. Am J Hum Genet 1991;48:1034–1050.

41. Pericak-Vance MA, Yamaoka LH, Haynes CS, et al. Genetic linkage studies in familial Alzheimer's disease. Exp Neurol 1988; 102:271–279.

42. Poirier J, Davignon J, Kogan S, Bertrand P, Gauthier S. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 1993; 342:697–699.

43. Prusiner SB. Molecular biology of prion diseases. Science 1991;252:1515–1522.

44. Rebeck G, Reiter J, Strickland D, Hyman B. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron 1993;11:575–580.

45. Rooke K, Talbot C, James L, Anand R, Hardy J, Goate A. A physical map of the human APP gene in YACs. Mammalian Genome 1993;4:662–669.

46. Ropers HH, Pericak-Vance MA, Siciliano MJ, Mohrenweiser HW. Report of the second international workshop on human chromosome 19 mapping. Cytogenet Cell Genet 1992;60:87–95.

47. Rumble B, Retallack R, Hilbich C, et al. Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. N Engl J Med 1989;320:1446–1452.

48. Saunders A, Schmader K, Breitner J, et al. Apolipoprotein E e4 allele distributions in late onset Alzheimer's disease and in other amyloid forming diseases. Lancet 1993;342:710–711.

49. Saunders A, Strittmatter W, Schmechel D, et al. Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467–1472.

50. Schellenberg GD, Anderson L, O'Dahl S, et al. APP717, APP693, and PRIP gene mutations are rare in Alzheimer's disease. Am J Hum Genet 1991;49:511–517.

51. Schellenberg GD, Bird TD, Wijsman EM, et al. Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. Science 1988;241:1507–1510.

52. Schellenberg GD, Bird TD, Wijsman EM, et al. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 1992;258:668–671.

53. Schellenberg GD, Boehnke M, Wijsman EM, Moore DK, Martin GM, Bird TD. Genetic association and linkage analysis of the apolipoprotein C11 locus and familial Alzheimer's disease. Ann Neurol 1992;31:223–227.

54. Schmechel D, Saunders A, Strittmatter W, et al. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA 1993;90:9649–9653.

55. Seubert P, Oltersdorf T, Lee MG, et al. Secretion of b-amyloid precursor protein cleaved at the amino terminus of the b-amyloid peptide. Nature 1993;361:260–263.

56. Seubert P, Vigo-Pelfrey C, Esch F, et al. Isolation and quantification of soluble Alzheimer's b-peptide from biological fluids. Nature 1992;359:325–327.

57. Sisodia S, Koo E, Beyreuther K, Unterbeck A, Price D. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 1990;248:492–494.

58. Snow AD, Mar H, Nochlin D, et al. The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease. Am J Pathol 1988;133:456–463.

59. St. George-Hyslop P, Haines J, Rogaev E, et al. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nature Genet 1992;2:330–334.

60. St. George-Hyslop PH, Tanzi RE, Polinsky RJ, et al. The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science 1987;235:885–890.

61. Strittmatter W, Weisgraber K, Huang D, et al. Binding of human apolipoprotein E to synthetic amyloid beta-peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci USA 1993;90:8098–8102.

62. Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to b-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease. Proc Natl Acad Sci USA 1993;90:1977–1981.

63. Van Broeckhoven C, Backhovens H, Cruts M, et al. Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3. Nature Genet 1992;2:335–339.

64. Van Broeckhoven C, Genthe AM, Vandenberghe A, et al. Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families. Nature 1987;329:153–155.

65. van Duijn CM, Stijnen T, Hofman A. Risk factors for Alzheimer's disease: overview of the EURODEM collaborative re-analysis of case–control studies. Int J Epidemiol 1991;20(Suppl 2):S4–S12.

66. van Duijn CM, Van Broechhoven C, Hardy JA, et al. Evidence for allelic heterogeneity in familial early onset Alzheimer's disease. Br J Psychiatry 1991;158:471–474.

67. Wang R, Meschai J, Cotter R, Sisodia S. Secretion of the b/A4 amyloid precursor protein. J Biol Chem 1991;266(25):16960–16964.

68. Wasco W, Brook JD, Tanzi RE. The amyloid precursor-like protein (aplp) gene maps to the long arm of human chromosome-19. Genomics 1993;15(1):237–239.

69. Weissenbach J, Gynapay G, Dib C, et al. A second-generation linkage map of the human genome. Nature 1992;359:794–801.

70. Wisniewski T, Frangione B. Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett 1992;135:235–238.