1. Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Ann Rev Neurosci 1986;9:357–381.

2. Andreasen NC: Brain imaging: applications in psychiatry. Science 1988;239:1381–1388.

3. Andreasen NC: Brain imaging: applications in psychiatry. Washington, DC: American Psychiatric Press; 1989.

4. Baxter LR. PET studies of cerebral function in major depression and obsessive-compulsive disorder: the emerging prefrontal cortex consensus. Ann Clin Psychiatry 1991;3:103–109.

5. Baxter LR. Neuroimaging studies of obsessive-compulsive disorder. Psychiatr Clin No Am 1992;15:871–884.

6. Baxter LR, Phelps ME, Mazziotta JC, et al. Cerebral metabolic rates for glucose in mood disorders. Arch Gen Psychiatry 1985;42:441–447.

7. Baxter LR, Phelps ME, Mazziotta JC, Guze BH, Schwartz JM, Selin CE. Local cerebral glucose metabolic rates in obsessive–compulsive disorder—a comparison with rates in unipolar depression and in normal controls. Arch Gen Psychiatry 1987;44:211–218.

8. Baxter LR, Mazziotta JC, Phelps ME, Selin CE, Guze BH, Fairbanks L. Cerebral glucose metabolic rates in normal human females vs. normal males. Psychiatry Res 1987;21:237–245.

9. Baxter LR, Schwartz JM, Mazziotta JC, et al. Cerebral glucose metabolic rates in nondepressed obsessive–compulsives. Am J Psychiatry 1988;145:1560–1563.

10. Baxter LR, Schwartz JM, Phelps ME, et al. Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychiatry 1989;46:243–250.

11. Baxter LR, Schwartz JM, Guze BH, Bergman K, Szuba MP. PET imaging in obsessive–compulsive disorder with and without depression. J Clin Psychiatry 1990;51(s):61–69.

12. Baxter LR, Schwartz JM, Guze BH, Bergman K, Szuba MP. Neuroimaging in obsessive–compulsive disorder: seeking the mediating neuroanatomy. In: Jenike MA, Baer L, Minichiello WE, eds. Obsessive–compulsive disorders: theory and management, 2nd ed. Chicago: Year Book Medical Publishers; 1990:167–188.

13. Baxter LR, Schwartz JM, Guze BH. Brain Imaging: toward a neuroanatomy of OCD. In Zohar Y, Insel TR, Rasmussen S, eds. The psychobiology of obsessive–compulsive disorder. New York: Springer-Verlag; 1991:101–125.

14. Baxter LR, Mazziotta JC, Pahl JJ, et al. Psychiatric, genetic, and positron emission tomographic evaluation of persons at risk for Huntington's disease. Arch Gen Psychiatry 1992;49:148–154.

15. Baxter LR, Schwartz JM, Bergman KS, et al. Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive–compulsive disorder. Arch Gen Psychiatry, 1992; 49:681–689.

16. Baxter LR, Guze BH. Neuroimaging in Tourette's and related disorders. In: Kurland R, ed. Handbook of Tourette's syndrome and related tic and behavioral disorders. Paris: Marcel Dekker; 1993:289–304.

17. Behar D, Rapoport JL, Berg CJ, Computerized tomography and neuropsychological test measures in adolescents with obsessive–compulsive disorder. Am J Psychiatry 1984;141:363–369.

18. Benkelfat C, Nordhal TE, Semple WE, King AC, Murphy DL, Cohen RM. Local cerebral glucose metabolic rates in obsessive–compulsive disorder: patients treated with clomipramine. Arch Gen Psychiatry 1990;47:840–848.

19. Blomqvist G, Bergstrom K, Bergstrom M, et al. Models for 11C-glucose. In: Greitz T, Ingvar DH, Widen L, eds. The metabolism of the human brain studied with positron emission tomography. New York: Raven Press; 1985.

20. Cummings JL, Frankel M. Gilles de la Tourette's syndrome and the neurological basis of obsessions and compulsions. Biol Psychiatry 1985;20:1117–1126.

21. Cummings JL. Frontal-subcortical circuits and human behavior. Arch Neurol 1993;50:873–880.

22. Drevets WC, Videen TO, MacLeod AK, Haller JW, Raichle ME. PET images of blood flow changes during anxiety: correction. Science 1992;256:1696.

23. Drevets WC, Videen TO, Price JL, Preskorn SH, Carmichael T, Raichle ME. A functional anatomical study of unipolar depression. J Neurosci 1992;12:3628–3641.

24. DeCristofaro MTR, Sessarego A, Pupi A, Biondi F, Faravelli C. Brain perfusion abnormalities in drug-naive, lactate-sensitive panic patients: a SPECT study. Biol Psychiatry 1993;33:505–512.

25. Freud S. The question of lay analysis (1926). In: Strachey J, ed. The standard edition of the complete psychological works of Sigmund Freud. Vol. 20. London: Hogarth Press; 1964:231.

26. Freud S. Project for a scientific psychology. In: Strachey J, ed. The standard edition of the complete psychological works of sigmund freud. Vol. 1. London: Hogarth Press; 1964:283–294.

27. Garber HJ, Ananth JV, Chiu LC, Griswold VJ, Oldendorf WH. Nuclear magnetic resonance study of obsessive–compulsive disorder. Am J Psychiatry 1989;146:1001–1005.

28. Giodani B, Boivin MJ, Berent S, Anxiety and cerebral cortical metabolism in normal persons. Psychiatry Res Neuroimag 1990;35:49–60.

29. Hoehn-Saric R, Pearlson GD, Harris GJ, Machlin SR, Camargo EE. Effects of fluoxetine on regional cerebral blood flow in obsessive–compulsive patients. Am J Psychiatry 1991;148:1243–1245.

30. Horwitz B, Swedo SE, Grady CL, et al. Cerebral metabolic pattern in obsessive–compulsive disorder: altered intercorrelations between regional rates of glucose utilization. Psychiatry Res Neuroimag 1991;40:221–237.

31. Husby G, van de Rijn I, Zabriskie JB, Abdin ZH, Williams RC. Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever. J Exp Med 1976;144:1094–1110.

32. Insel TR, Donnelly EF, Lalakea ML, Alterman IS, Murphy DL. Neurological and neuropsychological studies of patients with obsessive–compulsive disorder. Biol Psychiatry 1983;18:741–751.

33. Insel TR. Obsessive–compulsive disorder: a neuroethological perspective. Psychopharmacol Bull 1988;24:365–369.

34. Insel TR, Winslow JT. Neurobiology of obsessive–compulsive disorder. In: Jenike MA, Baer L, Minichiello WE, eds. Obsessive–compulsive disorders: theory and management, 2nd ed. Chicago: Year Book Medical Publishers; 1990:116–131.

35. Insel TR. Toward a neuroanatomy of obsessive–compulsive disorder. Arch Gen Psychiatry 1992;49:739–744.

36. Iversen SD. Behavioral aspects of cortico–subcortical interaction with special reference to frontostriatal relations. In: Reinoso-Suarez G, Ajmone-Marsan C, eds. Cortical integration. New York: Raven Press; 1984.

37. Kellner CH, Jolley RR, Holgate RC, et al. Brain MRI in obsessive–compulsive disorder. Psychiatry Res 1991;36:45–49.

38. Lear JL, Ackermann RF. Autoradiographic comparison of FDG-based and GLU-based measurements of cerebral glucose transport and metabolism: normal and activated conditions. In: Lassen NA, Ingvar DH, Raichle ME, Friberg L, eds. Brain work and mental activity: quantitative studies with radioactive tracers. Copenhagen: Munksgaard; 1991:142–157. (31st Alfred Benson Symposium).

39. Lepola U, Nousiainen U, Puranen M, Riekkinen P, Rimon R. EEG and CT findings in patients with panic disorder. Biol Psychiatry 1990;28:721–727.

40. Luxenberg JS, Swedo SE, Flament MF, Friedland RP, Rapoport J, Rapoport SI. Neuroanatomical abnormalities in obsessive– compulsive disorder determined with quantitative x-ray computed tomography. Am J Psychiatry 1988;145:1089–1093.

41. Machlin SR, Harris GJ, Pearlson GD, Hoehn-Saric R, Jeffery P, Camargo EE. Elevated medial-frontal cerebral blood flow in obsessive–compulsive patients: a SPECT study. Am J Psychiatry 1991;148:1240–1242.

42. Maricle RA, Sennhauser S, Burry M. Panic disorder associated with right parahippocampal infarction. J Nerv Ment Dis 1991;179:374–375.

43. Martinot JL, Allilaire JF, Mazoyer BM, et al. Obsessive– compulsive disorder: a clinical, neuropsychological and positron emission tomography study. Acta Psychiatr Scand 1990;82:233–242.

44. Martinot JL, Hardy P, Feline A, et al. Left prefrontal glucose hypometabolism in the depressed state: a confirmation. Am J Psychiatry 1990;147:1313–1317.

45. Mazziotta JC, Grafton ST, Woods RC. The human motor system studied with PET measurements of cerebral blood flow: topography and motor learning. In: Lassen NA, Ingvar DH, Raichle ME, Friberg L, eds. Brain work and mental activity: quantitative studies with radioactive tracers. Copenhagen: Munksgaard; 1991:280–293. (31st Alfred Benson Symposium).

46. Mindus P, Nyman H, Mogard J, Meyerson BA, Ericson K. Orbital and caudate glucose metabolism studied by positron emission tomography (PET) in patients undergoing capsulotomy for obsessive–compulsive disorder. In: Jenike MA, Asberg M, eds. Understanding obsessive–compulsive disorder (OCD). Toronto: Hogrefe & Huber Publishers; 1991:52–57.

47. Mindus P, Nyman HL. Normalization of personality characteristics in patients with incapacitating anxiety disorders after capsulotomy. Acta Psychiatr Scand 1991;83:283–291.

48. Mindus P. Capsulotomy in anxiety disorders: a multidisciplinary study. Stockholm: Karolinska Institute; 1991.

49. Modell JG, Mountx JM, Curtis GC, Greden JF. Neuropshysiological dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive–compulsive disorder. J Neuropsychiatry 1989;1:27–36.

50. Mountz JM, Modelll JG, Wilson MW, et al. Positron emission tomographic evaluation of cerebral blood flow during state anxiety in simple phobia. Arch Gen Psychiatry 1989;46:501–504.

51. Nauta WJH, Domesick VB. Afferent and efferent relationships of the basal ganglia. Functions of the basal ganglia. London: Pitman; 1984:3–29. (CIBA foundation Symposium #107).

52. Nordahl TE, Benkelfat C, Semple WE, Gross M, King AC, Cohen RM. Cerebral glucose metabolic rates in obsessive–compulsive disorder. Neuropsychopharmacology 1989;2:23–28.

53. Nordahl TE, Semple WE, Gross M, et al. Cerebral glucose metabolic differences in patients with panic disorder. Neuropshchopharmacology 1990;3:261–272.

54. Ontiveros A, Fontaine R, Breton G, Elie R, Fontaine S, Dery R. Correlation of severity of panic disorder and neuroanatomical changes on magnetic resonance imaging. J Neuropsychiatry Clin Neurosci 1989;1:404–408.

55. Parent A. Comparative Neurobiology of the Basal Ganglia. New York: John Wiley; 1986.

56. Pauls DL, Leckman JF. The inheritance of Gilles de la Tourette's syndrome and associated behaviors–evidence for autosomal dominant transmission. N Engl J Med 1986;315:993–997.

57. Phelps ME, Mazziotta JC. Positron emission tomography: human brain function and biochemistry. Science 1985;228:799–809.

58. Phelps ME, Mazziotta JC, Shelbert HR, eds. Positron emission tomography and autoradiography. New York: Raven Press; 1986.

59. Rapaport JL, Wise SP. Obsessive–compulsive disorder: is it a basal ganglia dysfunction? Psychopharm Bull 1988;24:380–384.

60. Rauch SL, Jenike MJ, Alpert NA, Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using 15O-labeled CO2 and positron emission tomography. Arch Gen Psychiatry 1994;51:62–70.

61. Reiman EM, Raichle ME, Butler FK, Herscovitch P, Robins E. A focal brain abnormality in panic disorder, a severe form of anxiety. Nature 1984;310:683–685.

62. Reiman EM, Raichle ME, Robins E, et al. Neuroanatomical correlates of a lactate-induced anxiety attack. Arch Gen Psychiatry 1989;46:493–500.

63. Reiman EM, Fusselman MJ, Fox PT, Raichle ME. Neuroanatomical correlates of anticipatory anxiety. Science 1989;243:1071–1074.

64. Rubin RT, Villanueva-Meyer J, Ananth J, Trajmar PG, Mena I. Regional 133Xe cerebral blood flow and cerebral 99mHMPAO uptake in unmedicated obsessive–compulsive disorder patients and matched normal control subjects: determination by high-resolution single-photon emission computed tomography. Arch Gen Psychiatry, 1992;49:695–702.

65. Rubin RT, Ananth J, Villanueva-Meyer J, Trajmar PG, Mena I. Regional xenon 133 cerebral blood flow and cerebral technetium 99m HMPAO uptake in patients with obsessive–compulsive disorder before and during treatment. Arch Gen Psychiatry [submitted].

66. Schneider JS. Review: basal ganglia role in behavior: importance of sensory gating and its relevance to psychiatry. Biol Psychiatry 1984;19:1693–1710.

67. Swedo SE, Rapoport JL, Cheslow DL, et al. High prevalence of obsessive–compulsive symptoms in patients with Sydenham's chorea. Am J Psychiatry 1989;146:246–249.

68. Swedo SE, Pietrini P, Leonard HL, et al. Cerebral glucose metabolism in childhood-onset obsessive–compulsive disorder: revisualization during pharmacotherapy. Arch Gen Psychiatry 1992; 49:690–694.

69. Swedo SE, Schapiro MB, Grady CL, et al. Cerebral glucose metabolism in childhood-onset obsessive–compulsive disorder. Arch Gen Psychiatry 1989;46:518–523.

70. Swerdlow NR, Koob GF. Dopamine, schizophrenia, mania and depression: toward a unified hypothesis of cortico-striato-pallidothalamic function. Behav Brain Sci 1987;10:197–245.

71. Teresa M, De Cristofaro DER, Sessarego A, Pupi A, Biondi F, Faravelli C. Brain perfusion abnormalities in drug-naive, lactate-sensitive panic patients: a SPECT study. Biol Psychiatry 1993; 33:505–512.

72. Thompson JM, Baxter LR, Schwartz JM. Freud, obsessive– compulsive disorder and neurobiology. Psychoanal Contemp Thought 1992;15:483–505.

73. Wik G, Fredrikson M, Ericson K, Driksson L, Stone-Elander S, Greitz T. A functional cerebral response to frightening visual stimulation. Psychiatry Res Neuroimag 1993;50:15–24.

74. Winslow JT, Insel T. Neuroethological models of obsessive– compulsive disorder. In: Zohar J, Insel T, Rasmussen S, eds. The psychobiology of obsessive–compulsive disorder New York: Springer-Verlag; 1991.

75. Wu JC, Buchsbaum MS, Hershey TG, Hazlett E, Sicotte N, Johnson JC. PET in generalized anxiety disorder. Biol Psychiatry 1991;29:1181–1199.

76. Zohar J, Insel TR, Berman KF, Foa EB, Hill JL, Weinberger DR. Anxiety and cerebral blood flow during behavioral challenge: dissociation of central from peripheral and subjective measures. Arch Gen Psychiatry 1989;46:505–510.

77. Zohar J, Insel TR. Obsessive-compulsive disorder: psychobiological approaches to diagnosis, treatment, and pathophysiology. Biol Psychiatry 1987;22:667–687.