Neurophysiological and Psychophysiological Approaches to Schizophrenia and Its Pathogenesis
Keith H. Nuechterlein, Ph.D.REFERENCES
1. Adler LE, Pachtman E, Franks RD, Pecevich M, Waldo MC, Freedman R. Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biol Psychiatry 1982;17:639-654.
2. Adler LE, Hoffer LJ, Griffith J, Waldo M, Freedman R. Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics. Biol Psychiatry 1992;32:607-616.
3. Andreasen NC. Negative symptoms in schizophrenia: Definition and reliability. Arch Gen Psychiatry 1982;39:784-788.
4. Anthony BJ. In the blink of an eye: Implications of reflex modification for information processing. In: Ackles PK, Jennings JR, Coles MGH, eds. Advances in psychophysiology, vol. 1. Greenwich, CT: JAI Press, 1985;167-218.
5. Asarnow RF, Granholm E, Sherman T. Span of apprehension in schizophrenia. In: Steinhauer SR, Gruzelier JH, Zubin J, eds. Handbook of schizophrenia, vol 5: Neuropsychology, psychophysiology, and information processing. Amsterdam: Elsevier, 1991;335-370.
6. Bernstein AS. Orienting response research in schizophrenia: Where we have come and where we might go. Schizophr Bull 1987;13:623-641.
7. Bernstein AS, Frith CD, Gruzelier JH, et al. An analysis of the skin conductance orienting response in samples of American, British, and German schizophrenics. Biol Psychology 1982;14:155-211.
8. Bernstein A, Taylor KW, Starkey P, Juni S, Lubowsky J, Paley, H. Bilateral skin conductance, finger pulse volume, and EEG orienting response to tones of differing intensities in chronic schizophrenics and controls. J Nerv Ment Dis 1981;169:513-528.
9. Blackwood DHR, St. Clair DM, Muir WJ, Duffy JC. Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees. Arch Gen Psychiatry 1991;48:899-909.
10. Boucsein, W. Electrodermal activity. New York: Plenum Press, 1992.
11. Boutros NN, Zouridakis G, Overall J. Replication and extension of P50 findings in schizophrenia. Clin Electroencephalogr 1991;22:40-45.
12. Braff DL. Information processing and attention dysfunctions in schizophrenia. Schizophr Bull 1993;19:233-259.
13. Braff DL, Geyer MA. Sensorimotor gating and schizophrenia: Human and animal model studies. Arch Gen Psychiatry 1990;47:181-188.
14. Braff DL, Grillon C, Geyer MA. Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry 1992;49:206-215.
15. Braff D, Stone C, Callaway E, Geyer M, Glick I, Bali L. Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 1978;15:339-343.
16. Callaway E, Naghdi S. An information processing model for schizophrenia. Arch Gen Psychiatry 1982;39:339-347.
17. Caine SB, Geyer MA, Swerdlow NR. Carbachol infusion into the dentate gyrus disrupts sensorimotor gating of startle in the rat. Psychopharmacology 1991;105:347.
18. Cannon TD, Mednick SA, Parnas J. Antecedents of predominantly negative and predominantly positive symptom schizophrenia in a high-risk population. Arch Gen Psychiatry 1990;47:622-632.
19. Cullum CM, Harris JG, Waldo MC, et al. Neurophysiological and neuropsychological evidence for attentional dysfunction in schizophrenia. Schizophr Res 1993;10:131-141.
20. Davis M, Gendelman DS, Tischler MD, Gendelman PM. A primary acoustic startle circuit: Lesion and stimulation studies. J Neurosci 1982;2:791-805.
21. Dawson ME, Hazlett EA, Filion DL, Nuechterlein KH, Schell AM. Attention and schizophrenia: Impaired modulation of the startle reflex. J Abnorm Psychol 1993;102:633-641.
22. Dawson ME, Nuechterlein KH. Psychophysiological dysfunctions in the developmental course of schizophrenic disorders. Schizophr Bull 1984;10:204-232.
23. Dawson ME, Nuechterlein KH, Schell AM. Electrodermal abnormalities in recent-onset schizophrenia: Relationships to symptoms and prognosis. Schizophr Bull 1992;18:295-311.
24. Dawson ME, Nuechterlein KH, Schell AM, Gitlin M, Ventura J. Autonomic abnormalities in schizophrenia: State or trait indicators? Arch Gen Psychiatry 1994;51:813-824.
25. Dawson ME, Nuechterlein KH, Schell AM, Mintz J. Concurrent and predictive electrodermal correlates of symptomatology in recent-onset schizophrenia patients. J Abnorm Psychol 1992;101:153-164.
26. Dawson ME, Schell AM, Filion DL. The electrodermal system. In: Cacioppo JT, Tassinary LG, eds. Principles of psychophysiology. Cambridge: Cambridge University Press, 1990;295-324.
27. Dawson ME, Schell AM, Swerdlow NR, Filion DL. Cognitive, clinical and neurophysiological implications of startle modification. In: Lang PJ, Simons RF, Balaban MT, eds. Attention and orienting: sensory and motivational processes. Hillsdale, NJ: Erlbaum, 1997;257-275.
28. DelPezzo EM, Hoffman HS. Attentional factors in the inhibition of a reflex by a visual stimulus. Science 1980;210:673-674.
29. Elbert T, Rockstroh B, Kowalik ZJ, et al. Chaotic brain activity. Electroencephalogr Clin Neurophysiol Supplement 1995;44:441-449.
30. Filion DL, Ciranni M. The functional significance of prepulse inhibition: A test of the protection of processing theory. Psychophysiology 1994;31:S46.
31. Filion DL, Dawson ME, Schell AM. Modification of the acoustic startle-reflex eyeblink: A tool for investigating early and late attentional processes. Biol Psychology 1993;35:185-200.
32. Ford JM, Pfefferbaum A, Roth W. P3 and schizophrenia. Ann NYAcad Sci 1992;658:146-162.
33. Freedman R, Adler LE, Waldo MC, Pachtman E, Franks RD. Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: Comparison of medicated and drug-free patients. Biol Psychiatry 1983;18:537-551.
34. Freedman R, Adler LE, Myles-Worsley M, et al. Inhibitory gating of an evoked response to repeated auditory stimuli in schizophrenic and normal subjects: human recordings, computer simulation, and an animal model. Arch Gen Psychiatry 1996;53:1114-1121.
35. Freedman R, Coon H, Myles-Worsley M, et al. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci USA 1997;94:587-592.
36. Freedman R, Mirsky AF. Event-related potentials: Exogenous components. In: Steinhauer SR, Gruzelier JH, Zubin J, eds. Handbook of schizophrenia, vol 5: Neuropsychology, psychophysiology, and information processing. Amsterdam: Elsevier, 1991;71-90.
37. Freedman R, Adler LE, Gerhardt GA, et al. Neurobiological studies of sensory gating in schizophrenia. Schizophr Bull 1987;13:669-678.
38. Friedman D. Endogenous scalp-recorded brain potentials in schizophrenia: A methodological review. In: Steinhauer SR, Gruzelier JH, Zubin J, eds. Handbook of schizophrenia, vol 5: Neuropsychology, psychophysiology, and information processing. Amsterdam: Elsevier, 1991;91-127.
39. Friedman D, Cornblatt B, Vaughan HG Jr, Erlenmeyer-Kimling L. Auditory event-related potentials in children at risk for schizophrenia: The complete initial sample. Psychiatry Res 1988;26:203-221.
40. Friedman D, Squires-Wheeler E. Event-related potentials (ERPs) as indicators of risk for schizophrenia. Schizophr Bull 1994;20:63-74.
41. Frith CD, Stevens M, Johnstone EC, Crow TJ. Skin conductance responsivity during acute episodes of schizophrenia as a predictor of symptomatic improvement. Psychol Med 1979;9:101-106.
42. Geyer MA, Swerdlow NR, Mansbach RS, Braff D. Startle response models of sensorimotor gating and habituation deficits in schizophrenia. Brain Res Bull 1990;25:485-449.
43. Gottesman II, Shields J. Schizophrenia: The epigenetic puzzle. New York: Cambridge University Press, 1982.
44. Graham, FK. The more or less startling effects of weak prestimulation. Psychophysiology 1975;12:238-248.
45. Grillon C, Ameli R, Charney DS, Krystal J, Braff DL. Startle gating deficits occur across prepulse intensities in schizophrenic patients. Biol Psychiatry 1992;32:939-943.
46. Gruzelier J, Raine A. Bilateral electrodermal activity and cerebral mechanisms in syndromes of schizophrenia and the schizotypal personality. Int J Psychophysiol 1994;16:1-16.
47. Gruzelier JH, Venables PH. Skin conductance orienting activity in a heterogeneous sample of schizophrenics: Possible evidence of limbic dysfunction. J Nerv Ment Dis 1972;155:277-287.
48. Guich SM, Buchsbaum MS, Burgwald L, et al. Effect of attention on frontal distribution of delta activity and cerebral metabolic rate in schizophrenia. Schizophr Res 1989;2:439-448.
49. Hackley SA, Graham FK. Effects of attending selectively to the spatial position of reflex-eliciting and reflex-modulating stimuli. J Exper Psychol 1987;13:411-424.
50. Hazlett EA, Buchsbaum MS, Haznedar MM, Biren M, Schnur DB. Impaired attentional modulation of startle in unmedicated schizophrenics. Psychophysiology 1996;33:S45.
51. Hazlett EA, Dawson ME, Buchsbaum MS, Nuechterlein KH. Reduced regional brain glucose metabolism assessed by PET in electrodermal nonresponder schizophrenics: A pilot study. J Abnorm Psychol 1993:102:39-46.
52. Hazlett EA, Dawson ME, Filion DL, Schell AM, Nuechterlein KH. Autonomic orienting and the allocation of processing resources in schizophrenia patients and putatively at-risk individuals. J Abnorm Psychol 1997;106:171-181.
53. Hazlett H, Dawson ME, Schell AM, Nuechterlein KH. Electrodermal activity as a prodromal sign in schizophrenia. Biol Psychiatry [in press].
54. Hillyard SA, Kutas M. Electrophysiology of cognitive processing. Ann Rev Psychol 1983;34:33-61.
55. Hoffman HS, Ison JR. Reflex modification in the domain of startle: 1. Some empirical findings and their implications for how the nervous system processes sensory input. Psychol Rev 1980;87:175-189.
56. Hoffman RE, Buchsbaum MS, Escobar MD, Makuch RW, Nuechterlein KH, Guich SM. EEG coherence of prefrontal areas in normal and schizophrenic males during perceptual activation. J Neuropsychiatr Clin Neurosci 1991;3:169-175.
57. Hoffman RE, Buchsbaum MS, Jensen RV, Guich SM, Tsai K, Nuechterlein KH. Dimensional complexity of EEG waveforms in neuroleptic-free schizophrenic patients and normal control subjects. J Neuropsychiatr Clin Neurosci 1996;8:436-441.
58. Hollister JM, Mednick SA, Brennan P, Cannon TD. Impaired autonomic nervous system habituation in those at genetic risk for schizophrenia. Arch Gen Psychiatry 1994;51:552-558.
59. Holzman PS. Eye movement dysfunctions in schizophrenia. In: Steinhauer SR, Gruzelier JH, Zubin J, eds. Handbook of schizophrenia, vol 5: Neuropsychology, psychophysiology, and information processing. Amsterdam: Elsevier, 1991;129-145.
60. Holzman PS, Matthysse S. The genetics of schizophrenia: A review. Psychol Sci 1990;1:279-286.
61. Hugdahl K. Psychophysiology: The mind-body perspective. Cambridge: Harvard University Press, 1996.
62. Hultman CM, Öhman A, Öhlund LS, Wieselgren I-M, Lindstrom LF, Öst, L-G. Electrodermal activity and social network predictors of outcome of episodes in schizophrenia. J Abnorm Psychol 1996;105:626-636.
63. Iacono WG, Clementz BA. A strategy for elucidating genetic influences on complex psychopathological syndromes (with special reference to ocular motor functioning and schizophrenia). Prog Exp Pers Res 1993;16:11-65.
64. Javitt DC. Neurophysiological approaches to analyzing brain dysfunction in schizophrenia. Psychiatr Ann 1993;23:144-150.
65. Judd LL, McAdams LA, Budnick B, Braff DL. Sensory gating deficits in schizophrenia: New results. Am J Psychiatry 1992;149:488-493.
66. Katsanis J, Iacono WG. Electrodermal activity and clinical status in chronic schizophrenia. J Abnorm Psychol 1994;103:777-783.
67. Kigogami Y, Yoneda H, Asaba H, Sakai T. P300 in first degree relatives of schizophrenics. Schizophr Res 1992;6:9-13.
68. Koch M, Kungel M, Herbert H. Cholinergic neurons in the pedunculopontine tegmental nucleus are involved in the mediation of prepulse inhibition of the acoustic startle response in the rat. Exp Brain Res 1993;97:71-82.
69. Koukkou M, Lehmann D, Wackermann J, et al. Dimensional complexity of EEG brain mechanisms in untreated schizophrenia. Biol Psychiatry 1993;33:397-407.
70. Koukkou M, Manske W. Functional states of the brain and schizophrenic states of behavior. In: Shagass C, Josiassen RC, Roemer RA, eds. Brain electrical potentials and psychopathology. New York: Elsevier, 1986;91-114.
71. Lee Y, Lopez DE, Meloni EG, Davis M. A primary acoustic startle pathway: Obligatory role of cochlear root neurons and the nucleus reticularis pontis caudalis. J Neurosci 1996;16:3775-3789.
72. Leitner DS, Cohen ME. Role of the inferior colliculus in the inhibition of acoustic startle in the rat. Physiol Behav 1985;34:65-70.
73. Leonard S, Adams C, Breese CR, et al. Nicotinic receptor function in schizophrenia. Schizophr Bull 1996;22:431-445.
74. Levy DL, Holzman PS, Matthysse, Mendell NR. Eye tracking dysfunction and schizophrenia: A critical perspective. Schizophr Bull 1993;19:461-536.
75. Lingenhohl K, Friauf E. Giant neurons in the rat reticular formation: a sensorimotor interface in the elementary acoustic startle circuit? J Neurosci 1994;14:1174-1194.
76. McCarley RW, Shenton ME, O'Donnell BF, et al. Auditory P300 abnormalities and left posterior superior temporal gyrus volume reduction in schizophrenia. Arch Gen Psychiatry 1993;50:190-197.
77. McDowd JM, Filion DL, Harris MJ, Braff DL. Sensory gating and inhibitory function in late-life schizophrenia. Schizophr Bull 1993;19:733-746.
78. McGhie A, Chapman J. Disorders of attention and perception in early schizophrenia. Br J Med Psychol 1961;34:103-116.
79. Michie PT, Fox AM, Ward PB, Catts CV, McConaghy N. Event-related potential indices of selective attention and cortical lateralization in schizophrenia. Psychophysiology 1990;27:209-227.
80. Morihisa JM, Duffy FH, Wyatt RJ. Brain electrical activity mapping (BEAM) in schizophrenic patients. Arch Gen Psychiatry 1983;40,719-728.
81. Norris CM, Blumenthal TD. A relationship between inhibition of the acoustic startle response and the protection of prepulse processing. Psychobiology 1996;24:160-168.
82. Nuechterlein KH. Vigilance in schizophrenia and related disorders. In: Steinhauer SR, Gruzelier JH, Zubin J, eds. Handbook of schizophrenia, vol 5. Neuropsychology, psychophysiology, and information processing. Amsterdam: Elsevier, 1991;397-433.
83. Nuechterlein KH, Dawson ME. A heuristic vulnerability/stress model of schizophrenic episodes. Schizophr Bull 1984a;10:300-312.
84. Nuechterlein KH, Dawson ME. Information processing and attentional functioning in the developmental course of schizophrenic disorders. Schizophr Bull 1984b;10:160-203.
85. Nuechterlein KH, Dawson ME, Gitlin M, et al. Developmental processes in schizophrenic disorders: Longitudinal studies of vulnerability and stress. Schizophr Bull 1992;18:387-425.
86. Öhman A, Öhlund LS, Alm T, Wieselgren I-M, Öst, L-G, Lindstrom LH. Electrodermal nonresponding, premorbid adjustment, and symptomatology as predictors of long-term functioning in schizophrenics. J Abnorm Psychol 1989;98:426-435.
87. Olbrich, R. The contributions of psychophysiology to vulnerability models. In: Häfner H, Gattaz WF, eds. Search for the causes of schizophrenia, vol II. Berlin: Springer Verlag, 1991;192-204.
88. Perry W, Braff DL. Information-processing deficits and thought disorder in schizophrenia. Am J Psychiatry 1994;151:363-367.
89. Pfefferbaum A, Ford JM, White P, Roth WT. P3 in schizophrenia is affected by stimulus modality, response requirements, medication status and negative symptoms. Arch Gen Psychiatry 1989;46:1035-1046.
90. Raine A, Lencz T. Brain imaging research on electrodermal activity in humans. In: Roy J-C, Boucsein W, Fowles DC, Gruzelier JH, eds. Progress in electrodermal research. New York: Plenum Press, 1993;115-135.
91. Rapp PE, Bashore TR, Martinerie JM, et al. Dynamics of brain electrical activity. Brain Tomogr 1989;2:99-118.
92. Roxborough H, Muir WJ, Blackwood DHR, Walker MT, Blackburn IM. Neuropsychological and P300 abnormalities in schizophrenics and their relatives. Psychol Med 1993;23:305-314.
93. Roy J-C, Boucsein W, Fowles DC, Gruzelier JH. Progress in electrodermal research. New York: Plenum Press, 1993.
94. Roy J-C, Sequeira H, Delerm B. Neural control of electrodermal activity: Spinal and reticular mechanisms. In: Roy J-C, Boucsein W, Fowles DC, Gruzelier JH, eds. Progress in electrodermal research. New York: Plenum Press, 1993;73-92.
95. Saitoh O, Niwa S, Hiramatsu K, Kameyama T, Rymar K, Itoh K. Abnormalities in late positive components of event-related potentials may reflect a genetic predisposition to schizophrenia. Biol Psychiatry 1984;19:293-303.
96. Schreiber H, Stolz-Born G, Rothmeier J, Kornhuber A, Kornhuber HH, Born J. Endogenous event-related potentials and psychometric performance in children at risk for schizophrenia. Biol Psychiatry 1991;30:177-189.
97. Schwartkopf S, Lamberti JS, Smith DA. Concurrent assessment of acoustic startle and auditory P50 evoked potential measures of sensory inhibition. Biol Psychiatry 1993;33:815-828.
98. Sequeira H, Roy J-C. Cortical and hypothalamo-limbic control of electrodermal responses. In: Roy J-C, Boucsein W, Fowles DC, Gruzelier JH, eds. Progress in electrodermal research. New York: Plenum Press, 1993;93-114.
99. Shagass C. EEG studies of schizophrenia. In: Steinhauer SR, Gruzelier JH, Zubin J, eds. Handbook of schizophrenia, vol 5: Neuropsychology, psychophysiology, and information processing. Amsterdam: Elsevier, 1991;39-69.
100. Siddle DAT, Spinks JA. Orienting, habituation, and the allocation of processing resources. In: Campbell BA, Hayne H, Richardson R, eds. Attention and information processing in infants and adults. Hillsdale, NJ: Erlbaum, 1992;227-262.
101. Siegel C, Waldo M, Mizner G, Adler LE, Freedman R. Deficits in sensory gating in schizophrenic patients and their relatives. Arch Gen Psychiatry 1984;41:607-612.
102. Spohn HE, Coyne L, Wilson JK, Hayes K. Skin-conductance orienting response in chronic schizophrenics: The role of neuroleptics. J Abnorm Psychol 1989;98:478-486.
103. Squires-Wheeler E, Friedman D, Erlenmeyer-Kimling L. A longitudinal study relating P3 amplitude to schizophrenia spectrum disorders and to global personality functioning. Biol Psychiatry 1993;33:774-785.
104. Strandburg RJ, Marsh JT, Brown WS, Asarnow RF, Guthrie, Higa J. Reduced attention-related negative potentials in schizophrenic children. Electroenceph Clin Neurophysiol 1991;79:291-307.
105. Straube, ER. On the meaning of electrodermal nonresponding in schizophrenia. J Nerv Ment Dis 1979;167:601-611.
106. Straube ER, Wagner W, Forerster K, Heimann H. Findings significant with respect to short- and medium-term outcome in schizophrenia—A preliminary report. Prog Neuropsychopharmacol Biol Psychiatry 1989;13:185-197.
107. Strauss JS, Carpenter WT. Prediction of outcome in schizophrenia: III. Five year outcome and its predictors. Arch Gen Psychiatry 1977;34:l59-l63.
108. Swerdlow NR, Braff DL, Bakshi VP, Geyer MA. An animal model of sensorimotor gating deficits in schizophrenia predicts antipsychotic drug action. In: Born GV, Cuatrecasas P, Ganten D, Herken H, Melmon H, eds. Handbook of experimental pharmacology. New York: Springer-Verlag, 1996;120:289-312.
109. Swerdlow NR, Braff DL, Geyer MA. GABAergic projection from nucleus accumbens to ventral pallidum mediates dopamine-induced sensorimotor gating deficits of acoustic startle in rats. Brain Res 1990;532:146-150.
110. Swerdlow NR, Braff DL, Taaid N, Geyer MA. Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Arch Gen Psychiatry 1994;51:139-154.
111. Swerdlow NR, Caine SB, Braff DL, Geyer, MA. The neural substrates of sensorimotor gating of the startle reflex: A review of recent findings and their implications. J Psychopharmacol 1992;6:132-146.
112. Swerdlow NR, Caine SB, Geyer MA. Regionally selective effects of intracerebral dopamine infusion on sensorimotor gating of the startle reflex in rats. Psychopharmacology 1992;108:189-195.
113. Swerdlow NR, Keith VA, Braff DL, Geyer MA. The effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine-inhibition of sensorimotor gating of the startle response in the rat. J Pharmacol Exp Ther 1991;256:530-536.
114. Swerdlow NR, Koob GF. Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico-striato-pallido-thalamic function. Behav Brain Sci 1987;197-245.
115. Tucker DM, Roth DL, Bair TB. Functional connections among cortical regions: topography of EEG coherence. Electroencephalogr Clin Neurophysiol 1986;63:242-250.
116. Waldo M, Carey G, Myles-Worsley M, et al. Codistribution of a sensory gating deficit and schizophrenia in multi-affected families. Psychiatry Res 1991;39:257-268.
117. Wan F-J, Caine SB, Swerdlow NR. The ventral subiculum modulation of prepulse inhibition is not mediated via dopamine D2 or nucleus accumbens non-NMDA glutamate receptor activity. Eur J Pharmacol 1996;314:9-18.
118. White P, Yee C. The effect of attentional and stressor manipulations on the P50 gating response. Psychophysiology [in press].
119. Wieselgren I-M, Öhlund LS, Lindstrom LH, Öhman A. Electrodermal activity as a predictor of social functioning in female schizophrenics. J Abnorm Psychol 1994;103:570-575.
120. Yamamoto K, Arai H, Nakayama S. Skin conductance response after 6-hydroxydopamine lesion of central noradrenaline system in cats. Biol Psychiatry 1990;28:151-160.
121. Yamamoto K, Hoshino T, Takahashi Y, Kaneko H, Ozawa N. Skin conductance activity after intraventricular administration of 6-hydroxydopa in rats. Biol Psychiatry 1991;29:365-375.
122. Yeomans JS, Frankland PW. The acoustic startle reflex: neurons and connections. Brain Res Rev 1996;21:301-314.
123. Zahn TP. Psychophysiological approaches to psychopathology. In: Coles MGH, Donchin E, Porges SW, eds. Psychophysiology: Systems, processes, and applications. New York: Guilford Press, 1986;508-610.
124. Zahn TP, Carpenter WT, McGlashan TH. Autonomic nervous system activity in acute schizophrenia: II Relationship to short-term prognosis and clinical state. Arch Gen Psychiatry 1981;38:260-266.
125. Zahn TP, Kruesi MJP, Swedo SE, Leonard HL, Rapoport JL. Autonomic activity in relation to cerebrospinal fluid neurochemistry in obsessive and disruptive children and adolescents. Psychophysiology 1996;33:731-739.
published 2000