The Effects of Neuroleptics on Plasma Homovanillic Acid

Arnold J. Friedhoff and Raul R. Silva
Department of Psychiatry
Millhauser Laboratories
New York University Medical Center
New York, New York 10016.

REFERENCES

1. Alpert M, Diamond F, Kesselman M. Correlation between extrapyamidal and therapeutic effects of neuroleptics. Comp Psychiatry 1977;18(4):333–338.

2. Alpert M, Diamond F, Weisenfreund J, Taleporos E, Friedhoff AJ. The neuroleptic hypothesis: study of covariation of extrapyramidal and therapeutic drug effects. Br J Psychiatry 1978;133:169–175.

3. Andreasen N. Modified scale for the assessment of negative symptoms (SANS). Iowa City: University of Iowa, 1984.

4. Bowers MB, Swigar ME, Jatlow PI, Giocoechea N. Plasma catecholamine metabolites and early response to haloperidol. J Clin Psychiatry 1984;45:248–251.

5. Bowers MB, Swigar ME, Jatlow PI, Hoffman FJ, Goicoecha N. Early neuroleptic response: clinical profiles and plasma catecholamine metabolites. J Clin Psychopharmacol 1987;7:83–86.

6. Chang WH, Chen TY, Lee CF, Hung JC, Hu WH, Yeh EK. Plasma homovanillic acid levels and subtyping of schizophrenia. Psychiatry Res 1988;23:239–244.

7. Davidson M, Davis KL. A comparison of plasma homovanillic acid concentrations in schizophrenic patients and normal controls. Arch Gen Psychiatry 1988;45(6):561–563.

8. Davidson M, Kahn RS, Warne P, et al. Changes in plasma homovanillic acid concentrations in schizophrenic patients following neuroleptic discontinuation. Arch Gen Psychiatry 1991;48:73–76.

9. Davidson M, Losonczy MF, Mohs RC, et al. Effects of debrisoquin and haloperidol on plasma homovanillic acid concentration in schizophrenic patients. Neuropsychopharmacology 1987;1:17–23.

10. Davila R, Gonzales-Torres M, Zumarraga M, Andia I, Guimon J, Friedhoff AJ. The ratio of plasma prolactin to homovanillic acid: a good predictor of clinical response in schizophrenia. [Submitted.]

11. Davila R, Manero E, Zumarraga M. Plasma homovanillic acid as a predictor of response to neuroleptics. Arch Gen Psychiatry 1988;45:564–567.

12. Davis KL, Davidson M, Mohs RC, et al. Plasma homovanillic acid concentration and the severity of schizophrenic illness. Science 1985;227:1601–1692.

13. Davis KL, Kahn RS, Ko G, et al. Dopamine in schizophrenia. Am J Psychiatry 1991;148:1474–1486.

14. Friedhoff AJ. Catecholamines and behavior. In: Ramachandran VS, ed. Encyclopedia of human biology. San Diego: Academic Press; 1991:217–224.

15. Green AI, Alam MY, Boshes RA, et al. Haloperidol response and plasma catecholamines and their metabolites. Schizophr Res 1993; 10:33–37.

16. Grodsky GM. Chemistry and functions of the hormones: in thyroid, pancreas, adrenal and gastrointestinal tract. In: Harper HA, Rodwell VW, Mayers PA, eds. Review of physiological chemistry. California: Lang Medical; 1979:511–555.

17. Landsberg L, Young JB. Physiology and pharmacology of the autonomic nervous system. In: Wilson JD, Braunwald E, Isselbacher KF, et al. eds. Principles of internal medicine. New York: McGraw-Hill; 1991:380–389.

18. Matthysse S. Antipsychotic drug actions: a clue to neuropathology of schizophrenia? Fed Proc 1973;32:200–205.

19. Mazure CM, Nelson JC, Jatlow PI, Bowers MB. Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis. Soc Biol Psychiatry 1991;30:475–482.

20. Meltzer H. Duration of a clozapine trial in neuroleptic-resistant schizophrenia. Arch Gen Psychiatry 1989;46:672.

21. Pickar D, Labarca R, Linnoila M, et al. Neuroleptic-induced decrease in plasma homovanillic acid and antipsychotic activity in schizophrenic patients. Science 1984;225:954–957.

22. Pickar D, Labarca R, Doran AR. Longitudinal measurement of plasma homovanillic acid levels in schizophrenic patients. Arch Gen Psychiatry 1986;43:669–676.

23. Steinberg JL, Garver DL, Moeller FG, Raese JD, Orsulak PL. Serum homovanillic acid levels in schizophrenic patients and normal control subjects. Psychiatry Res 1993;48:93–106.

24. Van Kammen DP. The biochemical basis of relapse and drug response in schizophrenia: review and hypothesis. Psychol Med 1991;21:881–895.

25. Van Putten T, Marder SR, Aravagiri M, Chabert N, Mintz J. Plasma homovanillic acid as a predictor of response to fluphenazine treatment. Psychopharm Bull 1989;1:89–91.

Back to Chapter

published 2000