Potential DA–5-HT interaction in schizophrenia. Shown is a diagram of potential DA–5-HT interactions and the specific 5-HT receptor subtypes that could be involved. In general, 5-HT exerts an inhibitory effect on neurotransmitter release. ACH, cholinergic neuron; DA, dopaminergic neuron; GABA, gaba-ergic neuron; GLu, glutamatergic neuron; VTA, ventral tegmental area; 5HT, serotonergic neuron.