TABLE 3. Alterations of 5-HT receptors in schizophernia

Receptor Ligand Direction of change Brain regions Ref.
5-HT1A [3H]-8-OH-DPAT Increase Crotex (Brodmann areas 10 and 11) Hashimoto et al. (24)
5-HT1A [3H]-8-OH-DPAT Increase Prefrontal cortex Hashimoto et al. (24)
5-HT1 [3H]-5-HT No change Prefrontal cortex Bennett et al. (6)
5-HT2 [3H]-spiperone No change Nucleus accumbens Mackay (47)
5-HT2 [3H]-LSD Decrease Brodmann areas 6, 8, 11, 44, 47 Bennett et al. (6)
5-HT2 [3H]-LSD No change Caudate nucleus Owen (62)
5-HT2 [3H]-LSD No change Brodmann areas 4, 10, 11 Whitaker et al. (85)
5-HT2 [3H]-LSD Increase (drug free) Brodmann areas 4, 10, 11 Whitaker et al. (85)
5-HT2 [3H]-ketanserin No change Brodmann area 10 Reynolds et al. (66)
5-HT2 [3H]-ketanserin Decrease (on and off drugs) Brodmann area 9 Mita et al. (52)
5-HT2 [3H]-spiperone Decrease Brodmann areas 8 and 9 Arora and Meltzer (2)
5-HT2 [125l]-LSD Increase Postcingulate cortex, ventral putamen,

n. accumbens, hippocampus

Joyce et al. (30)
5-HT1A [3H]-8-OH-DPAT Increase Hippocampus, postcingulate cortex,

motor and temporal cortex

Joyce et al. (30)
5-HT uptake

sites

[3H]-cyanoimipramine Decrease Anterior cingulate, postcingulate,

prefrontal and temporal cortex

Joyce et al. (30)
5-HT uptake

sites

[3H]-cyanoimipramine Increase Dorsal caudate, dorsal putamen,

ventral putamen, n. accumbens,

motor cortex

Joyce et al. (30)

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published 2000