TABLE 2. Affinity of mCPP, TFMPP, 5-HT , and MK-212

for various cloned 5-HT receptors (in nM)a

  5-HT mCPP TFMPP MK-212 Cimetidine
5-HT1Dß

5-HT2A

5-HT2B

5-HT2C

5-HT6

5HT7

 0.59

1,320

10

22

56

1.84

 90

231

26.8

204

2300

352

28

256

84.8

150

682

532

 N.D.

8,532

408

332

71,000

N.D.

 N.D

>10,000

N.D.

>10,000

>10,000

>10,000

a N.D. = not determined.

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published 2000