Test agent |
Receptor occupied (agonist/ antagonist) |
Result |
mCPP | 5-HT1C5-HT1D, 5-HT2 (weak agonist), 5-HT6, 5-HT7, |
Diminished PRL reponse compared to controls |
mCPP | 5-HT 1C, 5-HT 1D,5-HT2(weak agonist), 5-HT6, 5-HT7 |
Diminished cortisol response sompared to controls |
L-Tryptophan | All 5-HT receptors activated | No difference in PRL response compared to controls |
Fenfluramine | All 5-HT receptors activated | Diminished PRL response compared to controls |
MK-212 | 5-HT2c, 5-HT2A 5-HT1A (?) | Diminished temperature response compared to controls |
MK-212 + clozapine | 5-HT2, 5-HT1c activated; 5HT2, 5-HT1c, 5HT6, 5-HT7 blocked |
Blocked PRL and cortisol response to MK-212 |
Fenfluramine + clozapine | All 5-HT receptors activated; 5-HT2, 5-HT1c, 5-HT6, 5-HT7 blocked |
Blocked PRL response to fenfluramine |
L-Tryptophan + typical neuroleptics |
All 5-HT receptors activated; D2 receptors blocked |
Augmented PRL response to L-tryptophan Diminished GH response |
Cimetidine | 5-HT2 activated (indirect) | Diminished PRL response in schizophrenia compared to control |
Cimetidine + clozapine | 5-HT2 activated (indirect); 5-HT2, 5-HT1c, 5HT6, 5-HT7 blocked) |
Clozapine abolishes the PRL response induced by cimetidine |
published 2000