TABLE 1. Phenomena in the course of mood disorders modeled by kinding and behavioral sensitization
       
Descriptors Kinding Sensitization Phenomenona
Stressor vulnerability + + + + Initial stressors early in development may be

without effect but predispose to greater reactivity

upon rechallenge

Stressor precipitation + + + + Later stress may precipitate full-blown episode
Conditioning may be involved ¾ + + Stressors may become more symbolic
Episode autonomy + + ¾ Initially-precipitated episodes may occur

spontaneously

Cross-sensitization with

stimulants

¾ + + Comorbidity with drug abuse may work in both

directions (affective illness {ewc MVIMG, MVIMAGE,!biarrow.BMP} drug abuse)

Vulnerability to relapse + + + + S and K demonstrate long-term increases in

responsivity

Episodes may

a. become more severe

b. show more rapid onsets

+ +

+ +

+ +

S and K both show behavioral evolution in severity

or stages

Hyperactivity and stereotypy show more rapid

onsets

Anatomical and biochemical

substrates evolve

+ + + + K memory-trace evolves from unilateral to bilateral
IEGs involved + + + + IEGs, such as c-fos induced
Alterations in gene

expression occur

+ + + + IEGs may change gene expression, especially of

peptides over long time domains

Change in synaptic

microstructure occurs

+ + ¾ Neuronal sprouting and cell loss indicate structural

changes

Pharmacology differs as a

function or stage as a

evolution

+ + + + K differs as a function of stage; S differs as a

function of development versus expression

a S, sensitization; K, kinding.

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published 2000