TABLE 4. Triiodothyronine (T3)
Potentiation in patients resistant to TCAs
Ref. |
Sample |
Medication and Design |
Results |
Earle (27) |
25 retarded UP/BP outpatient females |
IMI 150 mg + thyroid
hormone, open label, trial length
not reported |
14 of 25 (56%) responders |
Ogura et al. (71) |
44 UP/BP males and females |
TCA + T3; open
label, trial length not reported |
29 of 44 (66%)responders |
Banki (5) |
49 UP/BP females 33 T3; 16
controls |
AMI 75-200 mg or AMI
75-200 mg + 20-40 mg of T3, open
label, trial length not reported |
T3: 23 of 33
(70%) responders Controls: 4 of 16 (25%) responders T3 > control |
Tsutsui et al. (111) |
11 males |
TCA + 5-25 mg of T3, open
label, trial length not reported |
10 of 11 (91%) responders |
Goodwin et al. (39) |
6 males, 6 females; 3 UP/9 BP |
IMI or AMI 150-300 mg + 25
or 50 µg of T3, 3
wks, double blind (within-subject-design) |
8 of 12 (67%) responders 4 of 12 (33%) remitted |
Targum et al. (101) |
7 males, 14 females; all UP |
TCA + 25 mg of T3 or 100
mg of thyroxine, 3 wks, open
label |
7 of 21 (33%) responders Subclinically hypothyroid:
5 of 6 (83%) Euthyroid patients: 2 of
15 (13%) |
Gitlin et al. (37) |
9 males, 7 females; all UP |
IMI, mean dose 206 mg,
4wks, ±25 mg of T3 or
placebo, 2 wks, double blind/crossover |
T3 = PBO.
Patients in both groups improved signigicantly. Response rates not
reported. |
Thase et al. (105) |
4 males, 16 females; all UP |
IMI, mean dose 240 mg,
{ewc MVIMG, MVIMAGE,!greateq.BMP}12 wks + 25 mg T3, 4 wks; 20
controls received continued IMI
without T3 |
T3: 5 of 20
(25%) responders Controls: 4 of 20 (20%) responders |
Joffe and Singer (46) |
14 males, 24 females; all UP |
Desipramine (n = 35) or
IMI (n = 5); dose 2.5-3.0 mg/kg. T3
(37.5 mg; n = 17) vs. T4
(150 µg; n = 21), 3 wks |
T3: 10 of 17
(59%) responders T4: 4 of 21
(19%) responders T3 > T4 |
Josse et al. (47) |
20 males, 31 females; all UP outpatients |
Desipramine (n = 46) or
IMI (n = 5); T3 (37.5 mg) vs. Li2CO3
(900mg) vs PBO; randomized,
double-blind |
T3: 10 of 17
(59%) responders LI: 9 of 17 (53%)
responders PBO: 3 of 16 (19%)
responders T3 = Li >
PBO |
published 2000