Long-Term Treatment of Mood Disorders / Table 1

TABLE 1. Maintenance treatment studies for unipolar disorder

		Length of
	Symptom-free	study
Study	interval	(yr)	Treatment	Total N	Outcome^a
Bjork et al. (11)	4 months	1	Zimelidine Placebo	38	Z > P
Coppen et al. (15)	6 months	1	Amitriptyline Placebo	29	A > P
Coppen et al. (16)	Undefined ^b	2	Lithium Placebo	26	L > P
Doogan et al. (18)	Undefined	1	Sertraline Placebo	295	S > P
Eric et al. (20)	Undefined	1	Paroxetine Placebo	125	Pa > P
Frank et al. (23)	17 weeks	3	Imipramine Placebo	51	I > P
Georgotis et al. (27)	4 months	1	Phenelzine Nortriptyline Placebo	51	Ph > P Ph > N N = P
Glen et al. (28)	Undefined	3	Lithium Amitriptyline Placebo	28	L = A = P
Kane et al. (37)	6 months	2	Lithium Imipramine Placebo	19	L > P L > I I = P
Montgomery et al. (49)	18 weeks	1	Fluoxetine Placebo	220	F > P
OADIG (53)	8 weeks	2	Diothepin Placebo	69	D > P
Prien et al. (60)	Undefined ^b	2	Lithium Imipramine Placebo	88	L > P I > P L = I
Prien et al. (62)	2 months	2	Lithium Imipramine Placebo	110	L > P I > P L > I
Robinson et al. (65)	16 weeks	2	Phenelzine Placebo	47	Ph > P
Rouillan et al. (67)	Undefined	1	Maprotiline Placebo	1141	M > P

^aBased on p = 0.05 level of significance.

^bMaintenance treatment initiated at discharge from hospital.