FIG. 2

Relative potency of representative antidepressants for neurotransmitter uptake inhibition and binding affinity for various receptor types. Data is presented as nanomolar concentrations derived from the inhibition constant (Ki) for blockade of neurotransmitter uptake in vitro using rat brain synaptosome and the equilibrium dissociation constant (Kd) for selected receptors in vitro using human brain tissues. n norepinephrine uptake , g 5-HT (serotonin) uptake, ¨ dopamine uptake, Ñ 5-HT-2A receptor, 5-HT-1A receptor, t alpha-1 adrenergic receptor , s alpha-2 adrenergic receptor, ¡ acetylcholine muscarinic receptor, ¨ histamine-1 receptor, à dopamine-2 receptor. Data are taken from Bolden-Watson and Richelson (9) and Cusak, et al (14).

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published 2000