TABLE 2. Biological and psychosocial factors relevant to circadian hypotheses
of affective illness
Factors |
Biological |
Psychosocial |
|
heredity intrauterine influences |
Developmental: poor parental bonding poor socialization learned helplessness
paradigm (uncontrollable stress) |
PREDISPOSING |
Pacemaker properties: abnormal period abnormal limits of
entrainment weak &/or altered
coupling altered sensitivity
&/or response to zeitgebers |
|
PRECIPITATING |
maturation/aging hormonal state season primary sleep disorders physical trauma |
Changes in Temporal Order:
family, social, work, meal
disruption jet lag shift work unusual pattern of chosen
behavior breakdown/loss of social
interactions separation or death |
PERPETUATING |
Zeitgebers absent or weak phase shifts change of photoperiod |
Stress: symbolic significance of
losses learned helplessness
paradigm (uncontrollable stress) |
PROTECTING |
absence of predisposing
factors lithium, tricyclics,
NAOI’s sleep-wake manipulations light exposure |
absence of predisposing
factors normal 24-hr social cues activity scheduling timing of treatments stress management |
Modified
and reprinted with permission from ref. 20.
published 2000