TABLE 1.  Time course of sleep-wake interventions in affective illness

 

 

Latency to therapeutic effect

Duration of therapeutic effect

Total sleep deprivation

hours

usually only 1 day

Partial sleep deprivation in the 2nd half

of the night

 

hours

 

usually only 1 day, longer if repeated

Phase advance of the sleep-wake cycle

3-7 days

1-2 weeks

REM sleep deprivation

2-3 weeks

months

Temporal isolation

3-14 days

changes with reentrainment

Total sleep deprivation followed by

phase advance

 

1 day

 

several days?

 

Comparison Treatments

 

Light therapy

3-4 days

1 or more weeks

Antidepressant drugs

10-30 days

months

 

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published 2000