FIG. 5

Plasma midazolam concentrations in a healthy volunteer who received a 0.1 mg/kg intravenous dose by constant-rate (zero-order) infusion over a period of 3 hr. The solid lines are the pharmacokinetic functions determined by simultaneous fitting of Eqs. 2 and 3 to data points during and after the infusion, respectively. Pharmacokinetic variables based on the fitted functions are indicated on the figure.

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published 2000