FIG. 3

Intracranial self-stimulation thresholds following 0, 3, 6, 12, 24, and 48 hr of cocaine self-administration at several time points postcocaine (0, 1, 3, 6, 12, 24, 48, and 72 hr). The results are expressed as percent change from baseline threshold levels. The mean ± SEM baseline threshold for the experimental group was 37.414 ± 2.516 mA and for the control group 35.853 ± 3.078 mA. The asterisks indicate statistically significant differences (p < 0.05) between control and experimental groups with Dunnett's tests after a significant group spent x hours interaction in the ANOVA. From Markou and Koob (46) with permission.

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published 2000