FIG. 2

Conditioned place aversions following a 6-day conditioning regimen with i.c.v. methylnaloxonium (MN) in naive vs. morphine-dependent rats, presented as group mean with standard errors (**p < 0.01). Ordinate shows the percent reduction in time spent in the MN-paired compartment (1 - test time/preconditioning time {ewc MVIMG, MVIMAGE,!times.bmp} 100%). Abscissa shows the dose of i.c.v. MN applied before conditioning sessions. From Hand et al. (31) with permission.

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published 2000