1. Baldwin HA, Koob GF. Rapid induction of conditioned opiate withdrawal. Neuropsychopharmacology 1993;8:15–21.

2. Bergman J, Kamien JB, Spealman RD. Antagonism of cocaine self-administration by selective dopamine D1 and D2 antagonist. Behav Pharmacol 1990;1:355–363.

3. Bertalmio AJ, Herling S, Hampton RY, Winger G, Woods JH. A procedure for rapid evaluation of the discriminative stimulus effects of drugs. J Pharmacol Exp Ther 1982;141:289–299.

4. Brady JV. Emotion revisited. J Psychiatr Res 1971;8:363–384.

5. Caine SB, Koob GF. Modulation of cocaine self-administration in the rat through D-3 dopamine receptors. Science 1993;260:1814–1816.

6. Caine SB, Lintz R, Koob GF. Intravenous drug self-administration techniques in animals. In: Sahgal A, ed. Behavioral neuroscience: a practical approach. New York: Oxford University Press; 1993:93–115.

7. Carr GD, Fibiger HC, Phillips AG. Conditioned place preference as a measure of drug reward. In: Liebman JM, Cooper SJ, eds. The neuropharmacological basis of reward. New York: Oxford University Press; 1989:264–319.

8. Carroll ME, Lac TL, Nygaard SL. A concurrently available nondrug reinforcer prevents the acquisition or decreases the maintenance of cocaine-reinforced behavior. Psychopharmacology 1989;97:23–29.

9. Childress AR, McLellan AT, Ehrman R, O'Brien CP. Classically conditioned responses in opioid and cocaine dependence: a role in relapse? NIDA Research Monograph 84. Rockville, MD: Department of Health and Human Services; 1988:25–43.

10. Collins RJ, Weeks JR, Cooper MM, Good PI, Russell RR. Prediction of abuse liability of drugs using IV self-administration by rats. Psychopharmacology 1984;82:6–13.

11. Colpaert FC, Lal H, Niemegeers CJE, Janssen PAJ. Investigations on drug produced and subjectively experienced discriminative stimuli. 1. The fentanyl cue, a tool to investigate subjectively experienced narcotic actions. Life Sci 1975;16:705–716.

12. Davis WM, Smith SG. Role of conditioned reinforcer in the initiation, maintenance and extinction of drug-seeking behavior. Pavlov J Biol Sci 1976;11:222–236.

13. Denoble U, Begleiter H. Response suppression on a mixed schedule of reinforcement during alcohol withdrawal. Pharmacol Biochem Behav 1976;5:227–229.

14. Ehrman RN, Robbins SJ, Childress AR, O'Brien CP. Conditioned responses to cocaine-related stimuli in cocaine abuse patients. Psychopharmacology 1992;107:523–529.

15. Elsmore TF, Fletcher GV, Conrad DG, Sodetz FJ. Reduction of heroin intake in baboons by an economic constraints. Pharmacol Biochem Behav 1980;13:729–731.

16. Emmett-Oglesby MW, Mathis DA, Moon RTY, Lal H. Animal models of drug withdrawal symptoms. Psychopharmacology 1990;101:292–309.

17. Fischman MW. Relationship between self-reported drug effects and their reinforcing effects: studies with stimulant drugs. In: Fischman MW, Mello NK, eds. Testing for abuse liability of drugs in humans. NIDA Research Monograph 92. Rockville, MD: Department of Health and Human Services; 1989:211–230.

18. France CP, Woods JH. Discriminative stimulus effects of naltrexone in morphine-treated rhesus monkeys. J Pharmacol Exp Ther 1989;250:937–943.

19. Gallistel CR. Self-stimulation. In: Deutsch JA, ed. The physiological basis of memory. New York: Academic Press; 1983:73–77.

20. Gauvin DV, Holloway FA. Cue dimensionality in the 3-choice pentylenetetrazole-saline-chlordiazepoxide discrimination task. Behav Pharmacol 1991;2:417–428.

21. Gellert VF, Holtzman SG. Discriminative stimulus effects of naltrexone in the morphine-dependent rat. J Pharmacol Exp Ther 1979;211:596–605.

22. Gellert VF, Sparber SB. A comparison of the effects of naloxone upon body weight loss and suppression of fixed-ratio operant behavior in morphine-dependent rats. J Pharmacol Exp Ther 1977;201:44–54.

23. Gerber GJ, Stretch R. Drug-induced reinstatement of extinguished self-administration behavior in monkeys. Pharmacol Biochem Behav 1975;3:1055–1061.

24. Goldberg SR. Stimuli associated with drug injections as events that control behavior. Pharmacol Rev 1976;27:325–340.

25. Goldberg SR, Gardner ML. Second-order schedules: extended sequences of behavior controlled by brief environmental stimuli associated with dosing administration. In: Thompson T, Johanson CE, eds. Behavioral pharmacology of human drug dependence. NIDA Research Monograph No. 37, DHEW Publication No. (ADM) 81-1137, Washington, DC: U.S. Government Printing Office; 1981:241–270.

26. Goldberg SR, Hoffmeister F, Schlichting V, Wolfgang W. Aversive properties of nalorphine and naloxone in morphine-dependent rhesus monkeys. J Pharmacol Exp Ther 1971;179:268–276.

27. Goldberg SR, Schuster CR. Suppression by a stimulus associated with nalorphine in morphine-dependent monkeys. J Exp Anal Behav 1967;10:235–242.

28. Goldberg SR, Schuster CR. Conditioned nalorphine-induced abstinence changes: persistence in post morphine-dependent monkeys. J Exp Anal Behav 1970;14:33–46.

29. Goldberg SR, Woods JH, Schuster CR. Morphine: conditioned increases in self-administration in rhesus monkeys. Science 1969;166:1306–1307.

30. Griffiths RR, Brady JV, Snell JD. Progressive ratio performance maintained by drug infusions: comparison of cocaine, diethylpropion, chlorphentermine, and fenfluramine. Psychopharmacology 1978;56:5–13.

31. Hand TH, Koob GF, Stinus L, Le Moal M. Aversive properties of opiate receptor blockade are centrally mediated and are potentiated by previous exposure to opiates. Brain Res 1988;474:364–368.

32. Holtzman SG. Discriminative stimulus effects of drugs: relationship to potential for abuse. In: Modern methods in pharmacology. Vol. 6. Testing and evaluation of drugs of abuse. New York: Wiley-Liss; 1990:193–210.

33. Holtzman SG, Villarreal JE. Operant behavior in the morphine-dependent rhesus monkey. J Pharmacol Exp Ther 1973;184(3): 528–541.

34. Johanson CE. Pharmacological and environmental variables affecting drug preference in rhesus monkeys. Pharmacol Rev 1976;27:343–355.

35. Johanson CE, Balster RL. A summary of the results of a drug self-administration study using substitution procedures in rhesus monkeys. Bull Narc 1978;30:43–54.

36. Katz JL, Goldberg SR. Second-order schedules of drug injection: implications for understanding reinforcing effects of abused drugs. In: Mello NK, ed. Advances in substance abuse. vol. 4. London: Jessica Kingsley Publishers; 1991:205–223.

37. Kelleher RT. Characteristics of behavior controlled by scheduled injections of drugs. Pharmacol Rev 1975;27:307–323.

38. Kelley AE, Delfs JM. Amphetamine and conditioned reinforcement. II. Contrasting effects of amphetamine microinjection into the nucleus accumbens with peptide microinjection into the ventral tegmental area. Psychopharmacology 1991;103:197–203.

39. Kokkinidis L, McCarter BD. Postcocaine depression and sensitization of brain stimulation reward: analysis of reinforcement and performance effects. Pharmacol Biochem Behav 1990;36:463–471.

40. Koob GF, Bloom FE. Cellular and molecular mechanisms of drug dependence. Science 1988;242:715–723.

41. Koob GF, Goeders N. Neuroanatomical substrates of drug self-administration. In: Liebman JM, Cooper SJ, eds. Neuropharmacological basis of reward, Vol. 6. New York: Oxford University; 1989:214–264.

42. Koob GF, Markou A, Weiss F, Schulteis G. Opponent process and drug dependence: Neurobiological mechanisms. Semin Neurosci 1993;5:351–358.

43. Kornetsky C, Esposito RU. Euphorigenic drugs: effects on reward pathways of the brain. Fed Proc 1979;38:2473–2476.

44. Lamb RJ, Preston KL, Schindler CW, et al. The reinforcing and subjective effects of morphine in post-addicts: a dose–response study. J Pharmacol Exp Ther 1991;259:1165–1173.

45. Leith NJ, Barrett RJ. Amphetamine and the reward system: evidence for tolerance and post-drug depression. Psychopharmacologia 1976;46:19–25.

46. Markou A, Koob GF. Post cocaine anhedonia. An animal model of cocaine withdrawal. Neuropharmacology 1991;4:17–26.

47. Markou A, Koob GF. Intracranial self-stimulation thresholds as a measure of reward. In: Sahgal A, ed. Behavioral neuroscience: a practical approach. New York: Oxford University Press; 1993:93–115.

48. Markou A, Weiss F, Gold LH, Caine SB, Schulteis G, Koob GF. Animal models of drug craving. Psychopharmacology 1993;112: 163–182.

49. McDonald RJ, White NM. A triple dissociation of memory systems: hippocampus, amygdala, and dorsal striatum. Behav Neurosci 1993;107(1):3–22.

50. Milliaressis E, Rompre PP, Laviolette P, Philippe L, Coulombe D. The wave-shift paradigm in self-stimulation. Physiol Behav 1986;37:85–91.

51. O'Brien CP, Jesta J, O'Brien TJ, Brady JP, Wells B. Conditioned narcotic withdrawal in humans. Science 1977;195:1000–1002.

52. Olds J, Milner P. Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. J Comp Physiol Psychol 1954;47:419–427.

53. Overton DA. Experimental methods for the study of state-dependent learning. Fed Proc 1974;33:1800–1813.

54. Piazza PV, Deminiere J-M, LeMoal M, Simon H. Factors that predict individual vulnerability to amphetamine self-administration. Science 1989;245:1511–1513.

55. Robbins TW. The potentiation of conditioned reinforcement by psychomotor stimulant drugs: a test of Hill's hypothesis. Psychopharmacologia 1975;45:103–114.

56. Roberts DCS, Loh EA, Vickers G. Self-administration of cocaine on a progressive ratio schedule in rats: dose–response relationship and effect of haloperidol pretreatment. Psychopharmacology 1989;97:535–538.

57. Robinson TE, Berridge KC. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Rev 1993;18:247–291.

58. Schulteis G, Carrera R, Markou A, Gold LH, Koob GF. Motivational consequences of naloxone-precipitated opiate withdrawal: a dose-response analysis. Neurosci Abstr 1993;19:1247.

59. Schuster CR, Johanson CE. Relationship between the discriminative stimulus properties and subjective effects of drugs. In: Colpaert FC, Balster RL, eds. Transduction mechanisms of drug stimuli. Berlin: Springer-Verlag, 1988;161.

60. Schuster CR, Thompson T. Self-administration and behavioral dependence on drugs. Annu Rev Pharmacol Toxicol 1969;9:483–502.

61. Schuster CR, Woods JH. The conditioned reinforcing effects of stimuli associated with morphine reinforcement. Int J Addict 1968;3:223–230.

62. Shannon HE. Pharmacological analysis of the phencyclidine-like discriminative stimulus properties of narcotic derivatives in rats. J Pharmacol Exp Ther 1982;222(1):146–151.

63. Stellar JR, Stellar E. The neurobiology of reward and motivation, New York: Springer-Verlag, 1985.

64. Stewart J, deWit H. Reinstatement of drug-taking behavior as a method of assessing incentive motivational properties of drugs. In: Bozarth MA, ed. Assessing the reinforcing properties of abused drugs. New York: Springer-Verlag; 1987:211–227.

65. Stewart J, Eikelboom R. Conditioned drug effects. In: Iversen LI, Iversen SD, Snyder SH, eds. New directions in behavioral pharmacology. Vol 19. New York: Plenum Press; 1987:1–57.

66. Stinus L, Le Moal M, Koob GF. The nucleus accumbens and amygdala as possible substrates for the aversive stimulus effects of opiate withdrawal. Neuroscience 1990;37:767–773.

67. Stolerman IP, Rasul F, Shine PJ. Trends in drug discrimination research analysed with a cross-indexed bibliography, 1984–1987. Psychopharmacology 1989;73:1–19.

68. Swerdlow NR, Gilbert D, Koob GF. Conditioned drug effects on spatial preference. In: Boulton AB, Baker GB, Greenshaw AJ, eds. Neuromethods. Vol 13. Clifton, NJ: The Humana Press, 1989;399–446.

69. van der Kooy D. Place conditioning: a simple and effective method for assessing the motivational properties of drugs. In: Bozarth MA, ed. Methods of assessing the reinforcing properties of abused drugs. New York: Springer-Verlag; 1987:229–240.

70. Wikler A. Dynamics of drug dependence: implications of a conditioning theory of research and treatment. Arch Gen Psychiatry 1973;28:611–616.

71. Wikler A, Pescor FT. Classical conditioning of a morphine abstinence phenomenon, reinforcement of opioid-drinking behavior and "relapse" in morphine addicted rats. Psychopharmacologia 1967;10:255–284.

72. Wikler A, Pescor FT, Miller D, Norrell H. Persistent potency of a secondary (conditioned) reinforcer following withdrawal of morphine from physically dependent rats. Psychopharmacology 1971;20:103–117.

73. Winger G, Woods JH. Comparison of fixed-ratio and progressive-ratio schedules of maintenance of stimulant drug-reinforced responding. Drug Alcohol Depend 1985;15:123–130.

74. Wise R. The neurobiology of craving: implications for the understanding and treatment of addiction. J Abnorm Psychol 1988;97:118–132.

75. Yanagita T. An experimental framework for evaluations of dependence liability of various types of drugs in monkeys. Bull Narc 1973;25:57–64.

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