Neuroendocrine Interactions
Bruce S. McEwen
Rockefeller University
1230 York Avenue, Box 165
New York, New York 10021
Tel: (212) 327-8624
Fax: (212) 327-8634
E-Mail: mcewen@rockvax.rockefeller.edu
REFERENCES
1. McEwen BS, Stellar
E. Stress and the Individual: Mechanisms leading to disease. Archives of Internal Medicine 1993;153:2093-2101.
2. Miner JN, Yamamoto
KR. Regulatory crosstalk at composite response elements. Trends in Biochem Sci 1991;16:423-426.
3. Landfield P. Modulation
of brain aging correlates by long-term alterations of adrenal steroids and neurally-active
peptides. Prog Brain Res 1987;72:279-300.
4. Baulieu EE. Steroid
hormones in the brain: several mechanisms?
In: AnonymousSteroid Hormone Regulation
of the Brain. London: Pergamon Press, 1981:3-14.
5. Baulieu EE. Neurosteroids:
a function of the brain. In: Costa E, Paul SM, eds. Neurosteroids and Brain Function. New York:
Thieme, 1991:63-73.
6. McEwen BS. Non-genomic
and genomic effects of steroids on neural activity. TIPS 1991;112:141-147.
7. Gee KW. Steroid
modulation of the GABA/Benzodiazepine receptor-linked chloride lonophore. Molecular Neurobiology 1988;2:291-317.
8. Orchinik M, Murray
TF, Moore FL. A corticosteroid receptor in neuronal membranes. Science 1991;252:1848
9. Orchinik M, Murray
TF, Franklin PH, Moore FL. Guanyl nucleotides modulate binding to steroid receptors
in neuronal membranes. Proc Natl acad
Sci USA 1992;89:3830
10. Blackmore PF, Neulen
J, Lattanzio F, Beebe SJ. Cell surface-binding sites for progesterone mediate
calcium uptake in human sperm. J Biol
Chem 1990;199:1266:18655
11. Wehling M, Christ
M, Thiesen K. Membrane receptors for aldosterone: a novel pathway for mineralocorticoid
action. Am J Physiol
1992;263:E974
12. Wong M, Moss RL.
Long-term and short-term electrophysiological effects of estrogen on the synaptic
properties of hippocampal CA1 neurons. The Journal of Neuroscience 1992;12:3217-3225.
13. McEwen BS, Alves
SH. Estrogens: Non-reproductive actions in the brain. Endocrine Rev 1998;
14. Erulkar SD, Wetzel
DM. 5 alpha dihydrotestosterone has nonspecific effects on membrane channels
and possible genomic effects on ACh-activated channels. J Neurophysiol
1989;61:1036-1052.
15. Rendt JM, Toro
L, Stefani E, Erulkar SD. Progesterone increases Ca currents in myometrial cells
from immature and nonpregnant adult rats. Am J Physiol 1992;262:C293-C301.
16. Toro L, Stefani
E, Erulkar SD. Hormonal regulation of potassium currents in single myometrial
cells. Proc Natl acad Sci USA
1990;87:2892-2895.
17. Joels M, DeKloet
ER. Control of neuronal excitability by corticosteroid hormones. Trends in Neurosci 1992;15:25-30.
18. McEwen BS, Cameron
H, Chao H, Gould E, Luine V, et al. Resolving a mystery: progress in understanding
the function of adrenal steroid receptors in hippocampus. Prog Brain Res 1994;100:149-157.
19. Pfaff DW. Estrogens and Brain Function. New York:
Springer-Verlag, 1980;-281.
20. McEwen BS. Our
changing ideas about steroid effects on an ever-changing brain. Seminars in Neurosciences 1991;3:497-507.
21. McEwen BS, Jones
K, Pfaff D. Hormonal control of sexual behavior in the female rat: molecular,
cellular and neurochemical studies. Biol
Reprod 1987;36:37-45.
22. Frankfurt M, Gould
E, Wolley C, McEwen BS. Gonadal steroids modify dendritic spine density in ventromedial
hypothalamic neurons: a golgi study in the adult rat. Neuroendo 1990;51:530-535.
23. Schumacher M, Coirini
H, Pfaff D, McEwen BS. Behavioral effects of progesterone associated with rapid
modulation of oxytocin receptors. Science 1990;250:691-694.
24. McEwen BS, Biegon
A, Davis P, et al. Steroid hormones: humoral signals which alter brain cell
properties and functions. In: AnonymousRecent
Progress in Hormone Research. New York: Academic Press, 1982:41-92.
25. Frye CA, Gardiner
SG. Progestins can have a membrane-mediated action in rat midbrain for facilitation
of sexual receptivity. Horm Behav
1996;30:682-691.
26. Flanagan L, Pfaus
J, Pfaff D, McEwen BS. Induction of FOS immunoreactivity in oxytocin neurons
after sexual activity in female rats. Neuroendo 1993;58:352-358.
27. Parsons B, McEwen
BS. Sequential inhibition of sexual receptivity by progesterone is not related
to decreased hypothalamic progestin receptors in the female rat. J Neurosci 1981;1:527-531.
28. Woolley C, McEwen
BS. Roles of estradiol and progesterone in regulation of hippocampal dendritic
spine density during the estrous cycle in the rat. J Comp Neurol 1993;336:293-306.
29. Stephan F. Coupling
between feeding-and light-entrainable circadian pacemakers in the rat. Physiol
Behav 1986;38:537-544.
30. McEwen BS, Angulo
J, Cameron H, Chao H, Daniels D, et al. Paradoxical effects of adrenal steroids
on the brain: protection versus degeneration. Biol.Psych. 1992;31:177-179.
31. McEwen BS, Sakai
RR, Spencer RL. Adrenal steroid effects on the brain: versatile hormones with
good and bad effects. In: Schulkin J, ed. Hormonally-Induced
Changes in Mind and Brain. San Diego: Academic Press, 1993:157-189.
32. Diamond DM, Bennett
MC, Fleshner M, Rose GM. Inverted-U relationship between the level of peripheral
corticosterone and the magnitude of hippocampal primed burst potentiation. Hippocampus
1992;2:421-430.
33. Rasika S, Nottebohm
F, Alvarez-Buylla A. Testosterone increases the recruitment and/or survival
of new high vocal center neurons in adult female canaries. Proc Natl
acad Sci USA
1994;91:7854-7858.
34. Calof AL, Hagiwara
N, Holcomb JD, Mumm JS, Shou J. Neurogenesis and cell death in olfactory epithelium.
J Neurobiol 1996;30:67-81.
35. Lim DA, Fishell
GJ, Alvarez-Buylla A. Postnatal mouse subventricular zone neuronal precursors
can migrate and differentiate within multiple levels of the developing neuraxis.
Proc Natl acad Sci USA
1997;94:14832-14836.
36. Goldman SA, Luskin
MB. Strategies utilized by migrating neurons of the postnatal vertebrate forebrain.
Trends in Neuroscience 1998;21:107-114.
37. McEwen BS. Stress,
sex, hippocampal plasticity: Implications for psychiatric illness. blank for now 1998;
38. Eriksson PS, Permlieva
E, Bjork-Eriksson T, Alborn A-M, Nordborg C, et al. Neurogenesis in the adult
human hippocampus. Nature Medicine
1998;4:1313-1317.(Abstract)
39. Gould E, McEwen
BS. Neuronal birth and death. Current
Opinion in Neurobiology 1993;3:676-682.
40. Sherry DF, Jacobs
LF, Gaulin SJC. Spatial memory and adaptive specialization of the hippocampus.
TINS 1992;15:298-303.
41. McEwen BS. Re-examination
of the glucocorticoid cascade hypothesis of stress and aging. In: Swaab D, Hoffman
M, Mirmiran R, Ravid F, van Leeuwen F, eds. Progress in Brain Research. Amsterdam:
Elsevier, 1992:365-383.
42. Joels M, DeKloet
ER. Control of neuronal excitability by corticosteroid hormones. TINS 1992;15:25-30.
43. Sapolsky R. Stress,
the Aging Brain and the Mechanisms of Neuron Death. Cambridge MIT Press 1992;1:423
44. Manuck SB, Kapley
JR, Adams MR, Clarkson TB. Studies of psychosocial influences on coronary artery
atherosclerosis in cynomolgus monkey. Health Psychol 1988;7:113-124.
45. Pouliot wA, Handa
RJ, Beck SG. Androgen Modulates N-Methyl-D-Aspartate-mediated Depolarization
in CA1 Hippocampal Pyramidal Cells. Synapse 1996;23:10-19.
46. Woolley C, McEwen
BS. Estradiol mediates fluctuation in hippocampal synapse density during the
estrous cycle in the adult rat. Journal
Neuroscience 1992;12:2549-2554.
47. McEwen BS. Possible
mechanisms for atrophy of the human hippocampus. Molecular Psychiatry 1997;2:255-262.
48. Weiner H. Perturbing the Organism: The Biology of Stressful
Experiences. Chicago, IL: University of Chicago Press, 1992;357pp
49. McEwen BS. Protective
and Damaging Effects of Stress Mediators. New England J Med 1998;338:171-179.
50. Munck A, Guyre
PM, Holbrook NJ. Physiological Functions of Glucocorticoids in Stress and Their
Relation to Pharmacological Actions. Endocrine
Review 1984;5:25-43.
51. Pacak K, Kvetnansky
R, Palkovits M, Fukuhara K, Yadid G, et al. Adrenalectomy augments in vivo release
of norepinephrine in the paraventricular nucleus during immobilization stress.
Endocrinology 1993;133:1404-1410.
52. Rubinow DR. The
premenstrual syndrome: New views. JAMA
1992;268:1908-1912.
53. Stone E, McEwen
BS, Herrera A, Carr K. Regulation of a and b components of noradrenergic cyclic
AMP response in cortical slices. Eur.J.Pharm.
1987;141:347-356.
54. Kuroda Y, Mikuni
M, Ogawa T, Takahashi K. Effect of ACTH, adrenalectomy and the combination treatment
on the density of 5-HT2 receptor binding sites in neocortex of rat forebrain
and 5-HT2 receptor-mediated wet-dog shake behaviors. Psychopharmacology 1992;108:27-32.
55. Imaki T, Nahan
J, Rivier C, Sawchenko P, Vale W. Differential regulation of corticotrophin-releasing
factor mRNA in rat brain regions by glucocorticoids and stress. Journal
Neuroscience 1991;11:585-599.
56. Swanson L, Simmons
DM. Differential steroid hormone and neural influences on peptide mRNA levels
in CRH cells of the paraventricular nucleus: a hybridization histochemical study
in the rat. Journal Comp Neurol 1989;285:413-435.
57. Azmitia E, McEwen
BS. Adrenocortical influence on rat brain tryptophan hydroxylase activity. Brain
Res 1974;78:291-302.
58. Paul SM, Purdy
RH. Neuroactive steroids. FASEB Journal
1992;6:2311-2322.
59. Edwards E, Harkins
K, Wright G, Henn F. Effects of bilateral adrenalectomy on the induction of
learned helplessness behavior. Neuropsychopharmacology
1990;3:109-114.
60. Sterling P, Eyer
J. Allostasis: A New Paradigm to Explain Arousal Pathology. In: Fisher S, Reason
J, eds. Handbook of Life Stress, Cognition
and Health. New York: John Wiley & Sons, 1988:629-649.
61. Manuck SB, Kaplan
JR, Adams MR, Clarkson TB. Studies of psychosocial influences on coronary artery
atherosclerosis in cynomolgus monkeys. Health Psychol 1995;7:113-124.
62. Manuck SB, Kaplan
JR, Muldoon MF, Adams MR, Clarkson TB. The behavioral exacerbation of atherosclerosis
and its inhibition by propranolol. In: McCabe PM, Schneiderman N, Field TM,
Skyler JS, eds. Stress, Coping And Disease.
Hove and London: Lawrence Erlbaum Associates, 1991:51-72.
63. Gould E, Woolley
C, McEwen BS. The hippocampal formation: morphological changes induced by thyroid,
gonadal and adrenal hormones. Psychoneuroendocrinology
1991;16:67-84.
64. Westlind-Danielsson A, Gould E, McEwen BS. Thyroid hormone causes
sexually distinct neurochemical and morphological alterations in rat septal-diagonal
band neurons. J Neurochem 1991;56:119-128.
65. Pavlides C, Westlind-Danielsson
A, Nyborg H, McEwen BS. Neonatal hyperthyroidism disrupts hippocampal LTP and
spatial learning. Exp Brain Res 1991;85:559-564.
66. Schwegler H, Crusio
WE, Lipp HP, Brust I, Mueller GG. Early postnatal hyperthyroidism alters hippocampal
circuitry and improves radial-maze learning in adult mice. J Neurosci 1991;11:2102-2106.
67. Adkins-Regan E.
Early organizational effects of hormones. Neuroendocrinology
of Reproduction 1981;159-228.
68. McEwen BS. Actions
of sex hormones on the brain: "organization" and "activation"
in relation to functional teratology. In: Boer G, Feenstra M, Mirmiran M, Swaab
D, Van Haaren F, eds. Progress in Brain Research, Vol. 73. Amsterdam: Elsevier, 1988:121-134.
69. Pfaff D. Morphological
changes in the brains of adult male rats after neonatal castration. J
Endocr 1966;36:415-416.
70. Raisman G, Field
P. Sexual dimorphism in the preoptic area of the rat. Science 1971;173:731-733.
71. Becker J, Breedlove
SM, Crews D. Behavioral Endocrinology
1992;MIT Press:574
72. Swaab D, Gooren
L, Hofman M. The human hypothalamus in relation to gender and sexual orientation.
Progress in Brain Research 1992;93:205-219.
73. Gorski RA, Gordon
JH, Shryne JE, Southam AM. Evidence for a morphological sex differences within
the medial preoptic area of the rat brain. Brain Res 1978;148:333-346.
74. Nottebohm F, Arnold
AP. Sexual dimorphism in vocal control areas of the songbird brain. Science 1976;194:211-213.
75. Forger NG, Breedlove
SM. Steroid influences on a mammalian neuromuscular system. Seminars in The Neurosciences 1991;3:459-468.
76. Allen LS, Richey
MF, Chai YM, Gorski RA. Sex differences in the Corpus Callosum of the Living
Human Being. The Journal of Neuroscience
1991;11:933-942.
77. Allen L, Gorski
R. Sexual dimorphism of the anterior commissure and massa intermeida of the
human brain. Journal Comp Neurol 1991;312:97-104.
78. Witelson SF. Hand
And Sex Differences In The Isthmus And Genu Of The Human Corpus Callosum A Postmortem
Morphological Study. Brain 1989;112:799-835.
79. Hier D. Sex differences
in hemispheric specialization: hypothesis for the excess of dyslexia in boys.
Bull Orton Soc 1979;29:74-83.
80. Allen L, Hines
M, Shryne J, Gorski R. Two sexually dimorphic cell groups in the human brain.
J Neurosci 1989;9:497-506.
81. Ehrhardt AA. Behavioral
sequellae of prenatal hormonal exposure in animals and man. Psychopharmacology: A Generation of Progress
1978;531-539.
82. Uno H, Ross T,
Else J, Suleman M, Sapolsky R. Hippocampal damage associated with prolonged
and fatal stress in primates. J Neurosci
1989;9:1709-1711.
83. Swaab D, Hofman
M. An enlarged suprachiasmatic nucleus in homosexual men. Brain Res 1990;537:141-148.
84. LeVay S. A difference
in hypothalamic structure between heterosexual and homosexual men. Science 1991;253:1036-1038.
85. Allen L, Gorski
R. Sexual orientation and the size of the anterior commissure in the human brain.
PNAS 1993;89:7199-7202.
86. Fride E, Dan Y,
Feldon J, Halevy G, Weinstock M. Effects of prenatal stress on vulnerability
to stress in prepubertal and adult rats. Physiol
Behav 1986;37:681-687.
87. Meaney M, Mitchell
J, Aitken D. The effects of neonatal handling on the development of the adrenocortical
response to stress: implications for neuropathology and cognitive deficit later
in life. Psychoneuroendo 1991;16:85-103.
88. Bonuccelli U, Melis
GB, Paoletti AM, Fioretti P, Murri L, et al. Unbalanced progesterone and estradiol
secretion in catamenial epilepsy. Epilepsy
Research 1989;3:100-106.
89. Herzog AG. Reproductive
endocrine considerations and hormonal therapy for women with epilepsy. Epilepsy
1991;62:S27-S33.
90. DeVane GW. Editorial:
Premenstrual Syndrome. J Clin Endocrinol
Metab 1991;72:250-251.
91. Orth-Gomer K. Intervention
on coronary risk factors by adapting a shift work schedule to biologic rhythmicity.
Psychosomatic Med 1983;45:407-415.
92. Regier DA, Boyd
JH, Burke JD, Rae DS, Myers JK, et al. One-month prevalence of mental disorders
in the U.S. Arch Gen Psychiatry 1988;45:977-986.
93. Bedard PJ, Langelier
P, Villeneuve A. Estrogens and the extrapyramidal system. The Lancet 1977;2:1367-1368.
94. Seeman MV, Lang
M. The role of estrogens in schizophrenia gender differences. Schizophrenia Bull 1990;16:185-194.
95. Mizoguchi K, Kunishita
T, Chui DH, Tabira T. Stress induces neuronal death in the hippocampus of castrated
rats. Neurosci Letts 1992;138:157-160.
Return to Chapter
published 2000