Figure 4

Regulation of gene expression by DNA-binding proteins. Steroid hormones bind to receptors that interact with simple response elements in promoter regions of certain genes and with composite response elements in promoter regions of other genes. Composite response elements require CREB or another DNA-binding protein that does not bind steroids. Complex response elements involve cooccupancy by two different DNA binding proteins, but these proteins can also interact with each other, including tethering or mutual inhibition. Adapted from Miner and Yamamoto (ref. 2).

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published 2000