Proto-Oncogenes / Table 1

TABLE 1. Functional classification of proto-oncogenes ^a

Class	Proto-oncogene nomenclature	Homolog
Receptor ligand	c-sis int-2 hst	PDGF B chain Basic-FGF-like FGF-like
Transmembrane tyrosine kinases	c-erbB c-fms neu (c-erbB-2) trk, trkB, trkC c-met c-kit c-ros c-sea	EGF receptor CSF -1 receptor EGF receptor-like Neurotrophin receptors Insulin receptor-like w locus gene Insulin receptor-like Insulin receptor-like
Membrane-associated tyrosine kinases	c-src hck c-abl c-yes-1 and-2 c-fgr c-lck c-fps/fes fer flk flk c-syn c-lyn c-slk fyn
Nontyrosine kinase receptors	mas	Angiotensin receptor
Serine/threonine kinases	c-raf-1 c-mos pim-1
G-protein-like	c-Ha-ras c-Ki-ras c-N-ras rab (1-4) ypt-1 rho smg
Signal transduction enzymes	crk	Phospholipase C-like
Nuclear proteins	c-ski c-erbA snoA and B ets-1 and -2 c-myb mybA and B	Thyroid hormone receptor Related to NFkB
Zinc finger proteins	gli gr-1 and -2	Related to krueppel Related to krueppel
Leucine zipper protein	c-fos fra-1 and -2 fosB c-jun, -B, -D	AP-1 complexes
Helix-loop-helix	c-myc N-myc L-myc

^a Reproduced with permission from Discussions in Neuroscience, vol. VII, no. 4, August 1991.

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