TABLE 3. Inhibitor constants of high-affinity CCK antagonists and agonists
 

IC50 for receptor

Antagonist

CCKA

CCKB

A-65186

5 nM

4 mM

CI988

3 mM

2 nM

L-364,718

1 nM

300 nM

L-365,260

300 nM

1 nM

LY262691

10 mM

30 nM

Agonist

CCKA

CCKB

BC 264

0.32

 

A-65186 (165), CI988 = PD134308 (69), L-

364,718 = MK329 = devazepide (28), L-

365,260 (13), LY262691 (131), BC 264 = Boc-Tyr(S03H)-gNle-Trp(nMc)Nle-Asp-Phe-Nh2

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published 2000