| Figure 4. |
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| Graph portraying the time course of the cellular and molecular events occurring after a single exposure of rat dorsolateral striatal neurons to haloperidol. Activation of c-fos mRNA production immediately precedes production of NT-NMN primary transcripts. This is followed by a steady increase over 7 hr in cytoplasmic mRNA for NT and NMN, which does not result in peak immunoreactive concentrations until around 16 hr after the initial haloperidol exposure. (From Merchant KM. Dobie DI, Dorsa DM. Expression of the proneurotensin gene in the rat brain and its regulation by antipsychotic drugs. In: Nemeroff CB, Kitabgi P, eds. The neurobiology of neurotensin. Annals of the New York Academy of Sciences, vol 668. New York: New York Academy of Sciences, 1992; 54-69., with permission.) |
published 2000