Figure 6. CRF-like immunoreactivity (a) and CRF receptor binding (b) in discrete regions of the cerebral cortex of Alzheimer's patients and controls. All values are means ± S.E.M. The number of subjects in each group is given at the bottom of each histogram. Significant differences from control group at p<0.01, p<0.05 and p<0.005 are denoted by *, ** and ***, respectively. NS, nonsignificant. (From ref. 33, by permission).