Table 1: Some Mammalian Neuropeptides and Neuropeptide Families
Hypothalamic hormones
Oxytocin (9 amino acid residues, a.a.r.)
Vasopressin (9 a.a.r.)
Hypothalamic releasing and inhibiting hormones
Corticotropin releasing hormone (CRH) (41 a.a.r.)
Growth hormone releasing hormone (GHRH) (44 a.a.r.)
Luteinizing hormone releasing hormone (LHRH) (10 a.a.r.)
Somatostatin growth hormone release inhibiting hormone (14 a.a.r. plus several forms)
Thyrotropin releasing hormone (TRH) (3 a.a.r.)
Tachykinins
Neurokinin a (substance K) (10 a.a.r.)
Neurokinin b (10 a.a.r.)
Neuropeptide K (36 a.a.r.)
Substance P (11 a.a.r.)
Opioid peptides
b-endorphin (30 a.a.r.)
Dynorphin (17 a.a.r. and other forms)
Met- and leu-enkephalin (5 a.a.r.)
NPY and related peptides
Neuropeptide tyrosine (NPY) (36 a.a.r.)
Pancreatic polypeptide (36 a.a.r)
Peptide tyrosine-tyrosine (PYY) (36 a.a.r.)
VIP-glucagon family
Glucogen-like peptide-1 (GLP-1) (29 a.a.r.)
Peptide histidine isoleucine (PHI) (27 a.a.r.)
Pituitary adenylate cyclase activating peptide (PACAP) (27 or 38 a.a.r.)
Vasoactive intestinal polypeptide (VIP) (28 a.a.r.)
Other peptides
Brain natriuretic peptide (32 a.a.r.)
Calcitonin gene-related peptide (CGRP) (a- and b-form) (37 a.a.r.)
Cholecystokinin (CCK) (8 a.a.r. and other forms)
Galanin (29 or 30 a.a.r.)
Islet amyloid polypeptide (IAPP) or amylin (37 a.a.r)
Melanin concentrating hormone (MCH) (19 a.a.r.)
Melanocortins (ACTH, a-MSH and others)
Neuropeptide FF (F8Fa) (8a.a.r)
Neurotensin (13 a.a.r.)
Parathyroid hormone related protein (34 or 37 a.a.r.)
‘Novel’ neuropeptides
Agouti gene-related protein (AGRP) (131 a.a.r.)
Cocaine and amphetamine regulated transcript (CART)/peptide
Endomorphin-1 and -2 (both 4 a.a.r.)
5-HT-moduline (4 a.a.r.)
Nociceptin/orphanin FQ (17 a.a.r.)
Nocistatin (17 a.a.r.)
Prolactin releasing peptide (20 or 31 a.a.r.)
Secretoneurin (33 a.a.r.)
Urocortin (40 a.a.r.; 45% sequence identity with CRH)
published 2000