G. K. Aghajanian
REFERENCES
1. Aghajanian GK. Serotonin-induced inward current in rat facial motoneurons: evidence for mediation by G proteins but not protein kinase C. Brain Res 1990;524:171174.
2. Aghajanian GK, Sprouse JS, Rasmussen K. Physiology of the midbrain serotonin system. In: Meltzer HY, ed. Psychopharmacology: The third generation of progress. New York: Raven Press, 1987; 141149.
3. Aghajanian GK, Rasmussen K. Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices. Synapse 1989;3:331338.
4. Andrade R, Chaput Y. 5-HT4-like receptors mediate the slow excitatory response to serotonin in the rat hippocampus. J Pharmacol Exp Ther 1991;257:930937.
5. Andrade R, Nicoll RA. Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. J Physiol (Lond) 1987;394:99124.
6. Araneda R, Andrade R. 5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience 1991;40:399412.
7. Ashby CR Jr, Edwards E, Harkins K, Wang RY. Characterization of 5-hydroxytryptamine-3 receptors in the medial prefrontal cortex: a microiontophoretic study. Eur J Pharmacol 1989;173:193196.
8. Ashby CR Jr, Jiang LH, Kasser RJ, Wang RY. Electrophysiological characterization of 5-hydroxytryptamine-2 receptors in rat medial prefrontal cortex. J Pharmacol Exp Ther 1989;252:171178.
9. Beck SG. 5-Carboxyamidotryptamine mimics only the 5-HT elicited hyperpolarization of hippocampal pyramidal cells via 5-HT1A receptor. Neurosci Lett 1989;99:101106.
10. Blier P, Lista A, deMontigny C. Differential properties of pre-and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus. I. Effect of spiperone. J Pharmacol Exp Ther 1992;265:715.
11. Blier P, Steinberg S, Chaput Y, deMontigny C. Electrophysiological assessment of putative antagonists of 5-hydroxytryptamine receptors: a single-cell study in the dorsal raphe nucleus. Can J Physiol Pharmacol 1989;67:98105.
13. Bobker DH, Williams JT. Serotonin agonists inhibit synaptic potentials in the rat locus ceruleus in vitro via 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptors. J Pharmacol Exp Ther 1989; 250:3743.
14. Bobker DH, Williams JT. Serotonin augments the cationic current Ih in central neurons. Neuron 1989;2:15351540.
15. Bobker DH, Williams JT. Serotonin-mediated inhibitory postsynaptic potential in guinea-pig prepositus hypoglossi and feedback inhibition by serotonin. J Physiol (Lond) 1990;422:447462.
16. Bockaert J, Fozard JR, Dumuis A, Clarke DE. The 5-HT4 receptor: a place in the sun. Trends Pharmacol Sci 1992;13:141145.
17. Carter BD, Medzihradsky F. Go mediates the coupling of the m opioid receptor to adenylyl cyclase in cloned neural cells and brain. Proc Natl Acad Sci USA 1993;90:40624066.
18. Chalmers DT, Watson SJ. Comparative anatomical distribution of 5-HT1A receptor mRNA and 5-HT1A binding in rat braina combined in situ hybridisation/in vitro receptor autoradiographic study. Brain Res 1991;561:5160.
19. Chaput Y, Araneda RC, Andrade R. Pharmacological and functional analysis of a novel serotonin receptor in the rat hippocampus. Eur J Pharmacol 1990;182:441456.
20. Charlety PJ, Aston-Jones G, Akaoka H, Buda M, Chouvet G. 5-HT decreases glutamate-evoked activation of locus coeruleus neurons through 5-HT 1A receptors. Neurophysiology 1991;421426.
21. Clement HW, Gemsa D, Wesemann W. Serotonin-norepinephrine interactions: a voltammetric study on the effect of serotonin receptor stimulation followed in the N. raphe dorsalis and the locus coeruleus of the rat. J Neural Trans 1992;88:1123.
22. Crain SM, Crain B, Makman MH. Pertussis toxin blocks depressant effects of opioid, monoaminergic and muscarinic agonists on dorsal-horn network responses in spinal cord-ganglion cultures. Brain Res 1987;400:185190.
23. Darrow EJ, Strahlendorf HK, Strahlendorf JC. Response of cerebellar Purkinje cells to serotonin and the 5-HT1A agonists 8-OH-DPAT and ipsapirone in vitro. Eur J Pharmacol 1990;175:145153.
24. Davies MF, Deisz RA, Prince DA, Peroutka SJ. Two distinct effects of 5-hydroxytryptamine on single cortical neurons. Brain Res 1987;423:347352.
25. Fagni L, Dumuis A, Sebben M, Bockaert J. The 5-HT4 receptor subtype inhibits K+ current in colliculi neurones via activation of a cyclic AMP-dependent protein kinase. Br J Pharmacol 1992; 105:973979.
26. Garratt JC, Alreja M, Aghajanian GK. LSD has high efficacy relative to serotonin in enhancing the cationic current Ih: intracellular studies in rat facial motoneurons. Synapse 1993;13:123134.
27. Gellman RL, Aghajanian GK. Pyramidal cells in piriform cortex receive a convergence of inputs from monoamine activated GABAergic interneurons. Brain Res 1993;600:6373.
28. Glaum SR, Brooks PA, Spyer KM, Miller RJ. 5-Hydroxytryptamine-3 receptors modulate synaptic activity in the rat nucleus tractus solitarius in vitro. Brain Res 1992;589:6268.
29. Innis RB, Nestler EJ, Aghajanian GK. Evidence for G protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons. Brain Res 1988;459:2736.
30. Joels M, Shinnick-Gallagher P, Gallagher JP. Effect of serotonin and serotonin analogues on passive membrane properties of lateral septal neurons in vitro. Brain Res 1987;417:99107.
31. Larkman PM, Kelly JS. Ionic mechanisms mediating 5-hydroxytryptamine- and noradrenaline-evoked depolarization of adult rat facial motoneurones. J Physiol (Lond) 1992;456:473490.
32. Larkman PM, Penington NJ, Kelly JS. Electrophysiology of adult rat facial motoneurones: the effect of serotonin (5-HT) in a novel in vitro brainstem slice. J Neurosci Methods 1989;28:133146.
33. Leslie RA, Moorman JM, Coulson A, Grahame-Smith DG. Serotonin2/1C receptor activation causes a localized expression of the immediate-early gene c-fos in rat brain: evidence for involvement of dorsal raphe nucleus projection fibres. Neuroscience 1993;53:457463.
34. Lovenberg TW, Baron BM, de Lecea L, Miller JD, Prosser RA, Rea MA, Foye PE, Racke M, Slone AL, Siegel BW, Danielson PE, Sutcliffe JG, Erlander MG. A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated the regulation of mammalian circadian rhythms. Neuron 1993;11:449458.
35. Luebke JI, Greene RW, Semba K, Kamond A, McCarley RW, Reiner PB. Serotonin hyperpolarizes cholinergic low-threshold burst neurons in the rat laterodorsal tegmental nucleus in vitro. Proc Natl Acad Sci USA 1992;89:743747.
36. Lum JT, Piercey MF. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. Eur J Pharmacol 1987;149:915.
37. Maricq AV, Peterson AS, Brake AJ, Myers RM, Julius D. Primary source and functional expression of the 5-HT3 receptor, a serotonin-gated ion channel. Science 1991;254:432437.
38. McCormick DA, Wang Z. Serotonin and noradrenaline excite GABAergic neurones of the guinea-pig and cat nucleus reticularis thalami. J Physiol (Lond) 1991;442:235255.
39. McCormick DA, Williamson A. Convergence and divergence of neurotransmitter action in human cerebral cortex. Proc Natl Acad Sci USA 1989;86:80988102.
40. Mengod G, Nguyen H, Lee H, Waeber C, Lubbert H, Palacios JM. The distribution and cellular localization of 5-HT1C receptor mRNA in the rodent brain examined by in situ hybridization histochemistry. Comparison with receptor binding distribution. Neuroscience 1990;35:577592.
41. Mengod G, Pompeiano M, Martinez-Mir MI, Palacios JM. Localization of the mRNA for the 5-HT2 receptor by in situ hybridization histochemistry. Correlation with the distribution of receptor sites. Brain Res 1990;524:139143.
42. Miquel MC, Doucet E, Boni C, El Mestikawy S, Matthiessen L, Daval G, Verge D, Hamon M. Central serotonin1A receptors: respective distributions of encoding mRNA, receptor protein and binding sites by in situ hybridization histochemistry, radioimmunohistochemistry and autoradiographic mapping in the rat brain. Neurochem Int 1991;19:453465.
43. Monsma FJ Jr, Shen Y, Ward RP, Hamblin MW, Sibley DR. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol 1993;43:320327.
44. Nedergaard S, Flatman JA, Engberg I. Excitation of substantia nigra pars compacta neurones by 5-hydroxytryptamine in vitro. NeuroReport 1991;2:329332.
45. Newberry NR. 5-HT1A receptors activate a potassium conductance in rat ventromedial hypothalamic neurones. Eur J Pharmacol 1992; 210:209212.
46. Newberry NR, Priestley T. A 5-HT1-like receptor mediates a pertussis toxin-sensitive inhibition of rat ventromedial hypothalamic neurons in vitro. Br J Pharmacol 1988;95:68.
47. North RA, Uchimura N. 5-Hydroxytryptamine acts at 5-HT2 receptors to decrease potassium conductance in rat nucleus accumbens neurones. J Physiol (Lond) 1989;417:112.
48. Pape HC, McCormick DA. Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current. Nature 1989;340:715718.
49. Penington NJ, Kelly JS. Serotonin receptor activation reduces calcium current in an acutely dissociated adult central neuron. Neuron 1990;4:751758.
50. Pennington NJ, Kelly JS, Fox AP. A study of the mechanism of Ca2+ current inhibition produced by serotonin in rat dorsal raphe neurons. J Neurosci 1991;11:35943609.
51. Pompeiano M, Palacios JM, Mengod G. Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat: correlation with receptor binding. J Neurosci 1992;12:440453.
52. Rahman S, Neuman RS. Activation of 5-HT2 receptors facilitates depolarization of neocortical neurons by N-methyl-D-aspartate. Eur J Pharmacol 1993;231:347354.
53. Rasmussen K, Aghajanian GK. Potency of antipsychotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2 binding affinity. Neuropsychopharmacology 1988;1:101107.
54. Rasmussen K, Aghajanian GK. Serotonin excitation of facial motoneurons: receptor subtype characterization. Synapse 1990;5:324332.
55. Ropert N. Inhibitory action of serotonin in CA1 hippocampal neurons in vitro. Neuroscience 1988;26:6981.
56. Ropert N, Guy N. Serotonin facilitates GABAergic transmission in the CA1 region of rat hippocampus in vitro. J Physiol (Lond) 1991;441:121136.
57. Scroggs RS, Anderson EG. 5-HT1 receptor agonists reduce the Ca++ component of sensory neuron action potentials. Eur J Pharmacol 1990;178:229232.
58. Segal M. Serotonin attenuates a slow inhibitory postsynaptic potential in rat hippocampal neurons. Neuroscience 1990;36:631641.
59. Segal M, Azmitia EC, Whitaker-Azmitia PM. Physiological effects of selective 5-HT1A and 5-HT1B ligands in rat hippocampus: comparison to 5-HT. Brain Res 1989;502:6774.
60. Sheldon PW, Aghajanian GK. Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriform cortex: evidence for the involvement of a 5-HT2-activated interneuron. Brain Res 1990;506:6269.
61. Sheldon PW, Aghajanian GK. Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: evidence for mediation by 5-HT1C receptors in pyramidal cells and 5-HT2 receptors in interneurons. Synapse 1991;9:208218.
62. Smrcka AV, Hepler JR, Brown KO, Sternweis PC. Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq. Science 1991;251:804808.
63. Stevens DR, McCarley RW, Greene RW. Serotonin1 and serotonin2 receptors hyperpolarize and depolarize separate populations of medial pontine reticular formation neurons in vitro. Neuroscience 1992;47:545553.
64. Sugita S, Shen KZ, North RA. 5-Hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala. Neuron 1992;8:199203.
65. Tani A, Yoshihara Y, Mori K. Increase in cytoplasmic free Ca2+ elicited by noradrenalin and serotonin in cultured local interneurons of mouse olfactory bulb. Neuroscience 1992;49:193199.
66. Todorovic S, Anderson EG. 5-HT2 and 5-HT3 receptors mediate two distinct depolarizing responses in rat dorsal root ganglion neurons. Brain Res 1990;511:7179.
67. White SR, Fung SJ. Serotonin depolarizes cat spinal motoneurons in situ and decreases motoneuron afterhyperpolarizing potentials. Brain Res 1989;502:205213.
68. Williams JT, Colmers WF, Pan ZZ. Voltage- and ligand-activated inwardly rectifying currents in dorsal raphe neurons in vitro. J Neurosci 1988;8:34993506.
69. Yakel JL, Jackson MB. 5-HT3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line. Neuron 1988;1:615621.
70. Yakel JL, Shao XM, Jackson MB. The selectivity of the channel coupled to the 5-HT3 receptor. Brain Res 1990;533:4652.
71. Yamazaki J, Fukuda H, Nagao T, Ono H. 5-HT2/5-HT1C receptor-mediated facilitatory action on unit activity of ventral horn cells in rat spinal cord slices. Eur J Pharmacol 1992;220:237242.
72. Zgombick JM, Beck SG, Mahle CD, Craddock-Royal B, Maayani S. Pertussis toxin-sensitive guanine nucleotide-binding protein(s) couple adenosine A1 and 5-hydroxytryptamine1A receptors to the same effector system in rat hippocampus: biochemical and electrophysiological studies. Mol Pharmacol 1989;35:484494.
published 2000