Gene Targeting Approaches to Serotonin Receptor Function

Laurence Tecott, M.D., Ph.D
UCSF Department of Psychiatry
Center for Neurobiology and Psychiatry
401 Parnassus Avenue, San Francisco, CA 94143-0984
Phone(415)476-7858
Fax: (415)476-7884.


REFERENCES

1. Blundell JE. Serotonin and the biology of feeding. Am J Clin Nutr 1992;55:155S-159S.

2. Boschert U, Amara DA, Segu L, Hen R. The mouse 5-hydroxytryptamine1B receptor is localized predominantly on axon terminals. Neuroscience 1994;58:167.

3. Crabbe JC, Phillips TJ, Feller DJ, et al. Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors. Nat Genet 1996;14:98-101.

4. Engel G, Gothert M, Hoyer D, Schlicker E, Hilenbrand K. Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn Schmiedebergs Arch Pharmacol 1986;332:1-7.

5. Furth PA, Onge L, Boger H, et al. Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci USA 1994;91:9302-9306.

6. Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, Bujard H. Transcriptional activation by tetracyclines in mammalian cells. Science 1995;268:1766-1769.

7. Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K. Deletion of DNA polymerase B gene segment in T cells using cell type-specific gene targeting. Science 1994;265:103-106.

8. Hoyer D, Middlemiss D. Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain. Trends Pharmacol Sci 1989;10:130-132.

9. Jenck F, Moreau JL, Mutel V, Martin JR. Brain 5-HT1C receptors and antidepressants. Prog Neuropsychopharmacol Biol Psychiatry 1994;18:563-574.

10. Kennett GA, Curzon G. Potencies of antagonists indicate that 5-HT1c receptors mediate 1-3(chlorophenyl) piperazine-induced hypophagia. Br J Pharmacol 1991;103:2016-2020.

11. Kitchener SJ, Dourish CT. An examination of the behavioral specificity of hypophagia induced by 5-HT1B, 5-HT1C and 5-HT2 receptor agonists using the post-prandial satiety sequence in rats. Psychopharmacology 1994;13:369-377.

12. Kuhn R, Schwenk F, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science 1995;269:1427-1429.

13. Lappalainen J, Zhang L, Dean M, et al. Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2C receptor gene. Genomics 1995;27:274-279.

14. Mansour SL, Thomas KR, Capecchi MR. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 1988;336:348-352.

15. Maura G, Raiteri M. Cholinergic terminals in rat hippocampus possess 5-HT1B receptors mediating inhibition of acetylcholine release. Eur J Pharmacol 1986;129:333-337.

16. Meltzer HY, Nash JF. Effects of antipsychotic drugs on serotonin receptors. Pharmacol Rev 1991;43:587-604.

17. Molineaux S, Jessell T, Axel R, Julius D. 5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system. Proc Natl Acad Sci USA 81989;6:6793-6797.

18. Owen EH, Logue SF, Rasmussen DL, Wehner JM. Differences in genetic background for animals involved in the assessment of cognitive function. Neuroscience Submitted

19. Ozaki HS, Wahlsten D. Cortical axon trajectories and growth cone morphologies in fetuses of acallosal mouse strains. J Comp Neurol 1993;336:595-604.

20. Pazos A, Palacios JM. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res 1985;346:205-230.

21. Raiteri M, Bonanno G, Vallebuona F. In vitro and in vivo effects of d-fenfluramine: no apparent relation between 5-hydroxytryptamine release and hypophagia. J Pharmacol Exp Ther 1995;273:643-649.

22. Samanin R, Mennini T, Ferraris A, Bendotti C, Borsini F, Garattini S. m-Chlorophenylpiperazine: a central serotonin agonist causing powerful anorexia in rats. Naunyn Schmiedebergs Arch Pharmacol 1979;308:159-163.

23. Saudou F, Amara DA, Dierich A, et al. Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science 1994;265:1875-1878.

24. Spedding M, Ouvry C, Duhault J, Dacquet C, Wurtman R. Neural control of dieting. Nature 1996;380:488.

25. Tecott LH. Serotonin receptor diversity: Implications for psychopharmacology. In: Review of psychiatry, Vol. 15. Dickstein LJ, Riba MB, Oldham JM, eds. Washington, DC: American Psychiatric Press, 1996;331-350.

26. Tecott LH, Brennan TJ, Guh L. Gene targeting approaches to analyze neurotransmitter receptor function. Sem Neurosci 1996;8:145-152.

27. Tecott LH, Sun LM, Akana SF, et al. Eating disorder and epilepsy in mice lacking 5HT2C serotonin receptors. Nature 1995;374:542-546.

28. Wright DE, Seroogy KB, Lundgren KH, Davis BM, Jennes L. Comparative localization of serotonin1A,1C, and 2 receptor subtype mRNAs in rat brain. J Comp Neurol 31995;51:357-373.

 

Back to Chapter

published 2000