Property
* Widely ramifying projections
* Diffuse innervation of cortex
* Laminar complementarity
* Regional selectivity of innervation
* Restricted nature of LC afferents
* Monotonic relationship between unit firing and arousal
stages
* Phasic responses to novel/intense stimuli
* Neurochemical evidence of increased NE turnover in
stress
* Enhanced signal-to-noise-ratios in terminal regions
* ‘Top-down’ frontal cortical control over locus coeruleus
activity
See Ref.; also see Chapters by Foote & Aston-Jones
and Valentino & Aston-Jones
in this volume.