Figure 2.

The effect of acute tail shock on two indices of hippocampal NE synthesis in naive and chronically cold-stressed rats. A: Extracellular DOPA accumulation during local infusion of NSD-1015 via the dialysis probe. Basal DOPA levels did not differ significantly between the two groups. In naive rats (solid bars), 30 min of intermittent tail shock (line) resulted in a 24% increase in extracellular DOPA (n = 6), whereas in chronically stressed rats (hatched bars) a 35% increase above baseline was recorded (n = 6). (From ref. 40.) B: Tissue DOPA accumulation after systemic administration of NSD-1015. Rats were injected with NSD-1015 (100 mg/kg, i.p.) and either placed back in their home cages for 30 min or exposed to 30 min of intermittent tail shock. All rats were then immediately decapitated, and hippocampus dissected out. Basal accumulation of DOPA (solid bars) did not differ between naive and chronically cold-stressed rats. Following 30 min of intermittent tail shock (hatched bars), DOPA accumulation was increased 45% over basal level in naive rats (n = 10) and 101% over basal level in chronically stressed rats (n = 12). (From ref. 41) All results are expressed as mean ± SEM; *, p < 0.05 versus respective baseline; †, p < 0.05 chronically cold-stressed versus naive rats.

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published 2000