1. Adams LM, Foote SL, Neville HJ. Effects of locally infused pharmacological agents on spontaneous and sensory-evoked activity of locus coeruleus neurons. Brain Res 1988;21:395–400.

2. Aghajanian GK, Wang YY. Common alpha-2 and opiate effector mechanisms in the locus coeruleus: intracellular studies in brain slices. Neuropharmacology 1987;26:789–800.

3. Akaoka H, Aston-Jones G. Opiate withdrawal-induced hyperactivity of locus coeruleus neurons is substantially mediated by augmented excitatory amino acid input. J Neurosci 1991;11:3830–3839.

4. Akaoka H, Aston-Jones G. Indirect serotonergic agonists attenuate neuronal opiate withdrawal. Neuroscience 1993;54:561–565.

5. Andrade R, Aghajanian GK. Locus coeruleus activity in vitro: intrinsic regulation by a calcium-dependent potassium conductance but not alpha 2-adrenoceptors. J Neurosci 1984;4(1):161–170.

6. Andrade R, Aghajanian GK. Opiate- and a2-adrenoceptor-induced hyperpolarizations of locus ceruleus neurons in brain slices: reversal by cyclic adenosine 3¢:5¢-monophosphate analogues. J Neurosci 1985;5(9):2359–2364.

7. Aston-Jones G, Akaoka H, Charlety P, Chouvet G. Serotonin selectively attenuates glutamate-evoked activation of locus coeruleus neurons in vivo. J Neurosci 1991;11:760–769.

8. Aston-Jones G, Chiang C, Alexinsky T. Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance. Prog Brain Res 1991;88:501–520.

9. Aston-Jones G, Foote SL, Bloom FE. Anatomy and physiology of locus coeruleus neurons: functional implications. In: Ziegler M, Lake CR, eds. Norepinephrine. Frontiers of clinical neuroscience, vol 2. Baltimore: Williams & Wilkins, 1984;92–116.

10. Aston-Jones G, Rajkowski J, Kubiak P, Alexinsky T. Locus coeruleus neurons in the monkey are selectively activated by attended stimuli in a vigilance task. J Neurosci 1994{ewc MVIMG, MVIMAGE,!infinity.bmp} press.

11. Aston-Jones G, Shiekhattar R, Rajkowski J, Kubiak P, Akaoka H. Opiates influence noradrenergic locus coeruleus neurons by potent indirect as well as direct effects. In: Hammer R, ed. The neurobiology of opiates. New York: CRC Press, 1993;175–202.

12. Aston-Jones G, Shipley MT, Ennis M, Williams JT, Pieribone VA. Restricted afferent control of locus coeruleus neurons revealed by anatomic, physiologic and pharmacologic studies. In: Marsden CA, Heal DJ, eds. The pharmacology of noradrenaline in the central nervous system. Oxford: Oxford University Press, 1990;187–247.

13. Aston-Jones G, Shipley MT, Chouvet G, et al. Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology. Prog Brain Res 1991;88:47–75.

14. Babstock DM, Harley W. Paragigantocellularis stimulation induces b-adrenergic hippocampal potentiation. Brain Res Bull 1992;28: 709–714.

15. Berridge CW, Foote SL. Effects of locus coeruleus activation on electroencephalographic activity in neocortex and hippocampus. J Neurosci 1991;11:3135–3145.

16. Berridge CW, Page ME, Valentino RJ, Foote SL. Effects of locus coeruleus inactivation on electroencephalographic activity in neocortex and hippocampus. Neuroscience 1993;55:381–393.

17. Christie MJ, Williams JT, North RA. Cellular mechanisms of opioid tolerance: studies in single brain neurons. Mol Pharmacol 1987;32(5):633–638.

18. Chu NS, Bloom FE. Activity patterns of catecholamine-containing potine neurons in the dorsolateral tegmentum of unrestrained cats. J Neurobiol 1974;5:527–544.

19. Correa-Sales C, Rabin BC, Maze M. A hypnotic response to dexmedetomidine, and a2-agonist, is mediated in the locus coeruleus in rats. Anesthesiology 1992;76:948–952.

20. Dahl D, Sarvey JM. Norepinephrine induces pathway-specific long-lasting potentiation and depression in the hippocampal dentate gyrus. Proc Natl Acad Sci USA 1989;86:4776–4780.

21. De Sarro GB, Ascioti C, Froio F, Libri V, Nistico G. Evidence that locus coeruleus is the site where clonidine and drugs acting at alpha-1-and alpha-2-adrenoceptors affect sleep and arousal mechanisms. Br J Pharmacol 1987;90:675–685.

22. Dunwiddie TV, Taylor M, Heginbotham LR, Proctor WR. Long-term increases in excitability in the CA1 region of rat hippocampus induced by b-adrenergic stimulation: possible mediation by cAMP. J Neurosci 1992;12(2):506–517.

23. Egan TM, Henderson G, North RA, Williams JT. Noadrenaline-mediated synaptic inhibition in rat locus coeruleus neurones. J Physiol 1983;345:477–488.

24. Foote SL, Berridge CW, Adams LM, Pineda JA. Electrophysiological evidence for the involvement of the locus coeruleus in alerting, orienting, and attending. Prog Brain Res 1991;88:521–532.

25. Foote SL, Bloom FE, Aston-Jones G. The nucleus locus coeruleus: new evidence of anatomical and physiological specificity. Physiol Rev 1983;63:844–914.

26. Foote SL, Morrison JH. Extrathalamic modulation of neocortical function. Annu Rev Neurosci 1987;10:67–95.

27. Harley CW. A role for norepinephrine in arousal, emotion and learning: limbic modulation by norepinephrine and the Kety hypothesis. Prog Neuropsychopharmacol Biol Psychiatry 1987;11:419–458.

28. Harley C. Noradrenergic and locus coeruleus modulation of the performant path-evoked potential in rat dentate gyrus supports a role for the locus coeruleus in attentional and memorial processes. In: Barnes CD, Pompeiano O, eds. Progress in brain research. Amsterdam: Elsevier Science Publishers, 1991;307–321.

29. Harley C, Milway JS, LaCaille J-C. Locus coeruleus potentiation of dentate gurus responses: evidence for two systems. Brain Res Bull 1989;22:643–650.

30. Heginbotham LR, Dunwiddie TV. Long-term increase in the evoked population spike in the CA1 region of rat hippocampus induced by b-adrenergic receptor activation. J Neurosci 1991;11:2519–2527.

31. Hillyard SA. Electrophysiology of human selective attention. Trends Neurosci 1985;8:400–405.

32. Hopkins WF, Johnston D. Noradrenergic enhancement of long-term potentiation at mossy fiber synapses in the hippocampus. J Neurophysio 1988;59(2):667–687.

33. Madison DV, Nicoll RA. Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampus. Nature 1982;299: 636–638.

34. McCormick DA. Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus. J Neurosci 1992; 12(1):278–289.

35. McCormick DA. Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity. Prog Neurobiol 1992;39:337–388.

36. McCormick DA. Cholinergic and noradrenergic modulation of thalamocortical processing. Trends Neurosci 1989;12(6):215–221.

37. McCormick DA, Prince DA. Noradrenergic modulation of firing pattern in guinea pig and cat thalamic neurons, in vitro. J Neurophysiol 1988;59(3):978–996.

38. McCormick DA, Wang Z. Serotonin and noradrenaline excite GABAergic neurones of the guinea-pig and cat nucleus reticularis thalami. J Physiol 1991;442:235–255.

39. Miyake M, Christie M, North R. Single potassium channels opened by opioids in rat locus ceruleus neurons. Proc Natl Acad Sci USA 1989;86:3419–3422.

40. Mouradian RD, Sessler FM, Waterhouse BD. Noradrenergic potentiation of excitatory transmitter action in cerebrocortical slices: evidence for mediation by an a1 receptor-linked second messenger pathway. Brain Res 1991;546:83–95.

41. Nakamura S, Sakaguchi T. Development and plasticity of the locus coeruleus: a review of recent physiological and pharmacological experimentation. Prog Neurobiol 1990;34(6):505–526.

42. North RA, Williams JT. Opiate activation of potassium conductance inhibits calcium action potentials in rat locus coeruleus neurones. Br J Pharmacol 1983;80(2):225–228.

43. North RA, Williams JT. On the potassium conductance increased by opioids in rat locus coeruleus neurones. J Physiol 1985;364:265–280.

44. North RA, Williams JT, Surprenant A, Christie MJ. Mu and delta receptors belong to a family of receptors that are coupled to potassium channels. Proc Natl Acad Sci USA 1987;84:5487–5491.

45. Osmanovic SS, Shefner SA. Gamma-aminobutyric acid responses in rat locus coeruleus neurones in vitro: a current-clamp and voltage-clamp study. J Physiol 1990;421:151–170.

46. Pineda JA, Foote SL, Neville HJ, Holmes T. Endogenous event-related potential in squirrel monkeys: the role of task relevance, stimulus probability, and behavioral response. Electroencephalogr Clin Neurophysiol 1988;70:155–171.

47. Rajkowski J, Kubiak P, Aston-Jones G. Activity of locus coeruleus neurons in behaving monkeys varies with focussed attention: short-and long-term changes. Soc Neurosci Abstr 1992;18:538.

48. Regenold JT, Illes P. Inhibitory adenosine a1-receptors on rat locus coeruleus neurones. An intracellular electrophysiological study. Naunyn Schmiedebergs Arch Pharmacol 1990;341(3):225–231.

49. Shen KZ, North RA. Muscarine increases cation conductance and decreases potassium conductance in rat locus coeruleus neurones. J Physiol 1992;455:471–485.

50. Shen KZ, North RA. Substance P opens cation channels and closes potassium channels in rat locus coeruleus neurons. Neuroscience 1992;50(2):345–353.

51. Shen KZ, North RA. Excitation of rat locus coeruleus neurons by adenosine 5¢-triphosphate: ionic mechanism and receptor characterization. J Neurosci 1993;13(3):894–899.

52. Stanton PK, Sarvey JM. Norepinephrine regulates long-term potentiation of both the population spike and dendritic EPSP in hippocampal dentate gyrus. Brain Res Bull 1987;18:115–119.

53. Steriade M, Datta S, Pare D, Oakson G, Dossi RC. Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems. J Neurosci 1990;10:2541–2559.

54. Vanderwolf CH. Cerebral activity and behavior: control by central cholinergic and serotonergic systems. Int Rev Neurobiol 1988;30: 225–341.

55. Wang YY, Aghajanian GK. Excitation of locus coeruleus neurons by vasoactive intestinal peptide: role of a cAMP and protein kinase A. J Neurosci 1990;10(10):3335–3343.

56. Wang Z, McCormick DA. Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R-ACPD. J Neurosci 1993;13:2199–2216.

57. Washburn M, Moises HC. Electrophysiological correlates of presynaptic a2-receptor-mediated inhibition of norepinephrine release at locus coeruleus synapses in dentate gyrus. J Neurosci 1989; 9:2131–2140.

58. Waterhouse BD, Azizi A, Burne RA, Woodward DJ. Modulation of rat cortical area 17 neuronal responses to moving visual stimuli during norepinephrine and serotonin microiontophoresis. Brain Res 1990;546:276–292.

59. Waterhouse BD, Sessler FM, Cheng J, Woodward DJ, Azizi A, Moises HC. New evidence for a gating action of norepinephrine in central neuronal circuits of mammalian brain. Brain Res Bull 1988;21:425–432.

60. Williams JT, Henderson G, North RA. Characterization of alpha 2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones. Neurosci 1985;14(1):95–101.

61. Williams JT, Marshall KC. Membrane properties and adrenergic responses in locus coeruleus neurons of young rats. J Neurosci 1987;7(11):3687–3694.

62. Williams JT, North RA. Catecholamine inhibition of calcium actin potentials in rat locus coeruleus neurones. Neuroscience 1985;14 (1):103–109.

63. Woodward DJ, Moises HC, Waterhouse BD, Hoffer BJ, Freedman R. Modulatory actions of norepinephrine in the central nervous system. Fed Proc 1979;38:2109–2116.

64. Xiong HG, Marshall KC. Angiotensin II modulation of glutamate excitation of locus coeruleus neurons. Neurosci Lett 1990;118 (2):261–264.