| Figure 3. |
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| Proposed transmembrane topology and structural features of SERT and NET subunits. Note the 12 proposed transmembrane domains (TMDs), the large extracellular loop between TMD3 and TMD4 bearing multiple N-linked glycosylation sites, cytoplasmic -NH2 and -COOH tails, and sites for potential intramolecular or intermolecular disulfide bridge formation and phosphorylation. |
published 2000