Receptors and variants

Amino acids

Characteristics

% Prevalence;

Refs.

D1-like:

D1

446

~100%

(183)

D5

477

~100%

(184)

D5 pseudo-1

154

Stops before TM 4

~100%

(110)

D5 pseudo-2

154

Stops before TM 4

~100%

(110)

D2-like:

D2 long

443

~97-100%

(55)

D2 short

414

Loop 3 is missing 29 AA

~97-100%

(125)

D2 V96A

443

Valine replaced by alanine at 96 in TM2

~0.8%

(47)

D2 P310S

443

Proline replaced by serine at 310 (loop 3)

~0.4%

(47)

D2 S311C

443

Serine replaced by cysteine at 311 (loop 3)

~3%

"(47), (65)"

D3

400

~72%

(50)

D3 S9G

400

Serine replaced by glycine at 9

~28%

(79)

D3nf

342

Stops before TM 6

in SZ & Aff.D.

(143)

D3(TM4 del)

138

Stops after TM 3; no binding

(106)

D3(TM3 del)

109

Stops after TM 2; no binding

(174)

D4

D4.2

387

Loop 3 has 2 repeats of 16 amino acids each

"(88), (191)"

D4.3

403

Loop 3 has 3 repeats

"(88), (191)"

D4.4

419

Loop 3 has 4 repeats

"(88), (191)"

D4.5

435

Loop 3 has 5 repeats

"(88), (191)"

D4.6

451

Loop 3 has 6 repeats

"(88), (191)"

D4.7

467

Loop 3 has 7 repeats

"(88), (191)"

D4.8

483

Loop 3 has 8 repeats

"(88), (191)"

D4.9

499

Loop 3 has 9 repeats

"(88), (191)"

D4.10

515

Loop 3 has 10 repeats

"(88), (191)"

D4(del)

AlaSerAlaGly missing before TM 1

~8% (Italy)

(24)

D4 V194G

Valine replaced by glycine at 194

10-15% Africans

"(90), (162)"

del = Has deletion; AA = amino acid

nf = non-functional; SZ = schizophrenia; Aff.D. = affective disorder

TM = hydrophobic transmembrane region.

"There are over 20 different types of repeat units, each repeat unit

being designated by a different Greek letter (88)".