| Figure 8. |
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| Demonstration of dimers and monomers of the dopamine D2 receptor, as detected by radiophotolabeling of D2 receptors by means of [125I]iodoazido-nemonapride (adapted from ref. 204). After exposing the mixture of D2 receptors and the photolabel to light, the tissue was electrophoresed on an acrylamide gel. The lane on the left shows that the photolabel revealed D2 monomers at 48,000 MW and at 98,000 MW, while the lane on the right indicates the nonspecific binding of the photolabel in the presence of 100 nM (+)-butaclamol (204)). |
published 2000