| Figure 1. |
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| Left: The neuroleptic dissociation constants (K) at the dopamine D2 receptor correlate with the daily antipsychotic doses used clinically. Right: The neuroleptic dissociation constants at the D2 receptor closely match the free neuroleptic concentrations in the patients' plasma water or spinal fluid. Each point indicates a K value published from a different laboratory (146). The concentration for clozapine includes that of its major metabolite (norclozapine, or desmethylclozapine). The molarities in plasma water for cis-flupentixol and for S-sulpiride are half those published for the racemates (which are used clinically). [Adapted from ref. 146] |
published 2000