| |
N-STR
|
M-ACC
|
M-PFR
|
M-PIR
|
M-AMY
|
TINF
|
THYP
|
IHYP
|
OLF-B
|
RETN
|
|
Perikarya location:
|
A9 > A8 > A10
|
A10 > A8 > A9
|
A10
|
A9 > A8
|
A8, A9, A10
|
A12
|
A12
|
A11, A13, A14
|
A16
|
A17
|
|
Efferent fiber length:
|
Long
|
Long
|
Long
|
Long
|
Long
|
Interm.
|
Interm.
|
Interm. and
long
|
Short
|
Short
|
|
Possible functions:
|
Motor
|
Reward,
emotion
|
Cognition
|
Cognition
|
Integration
of sensory
stimuli
|
Pituitary
hormone
release
|
Pituitary
hormone
release
|
Pituitary
hormone
release
|
Olfaction
|
Light/dark
adaptation
|
|
High-affinity DA uptake:
|
Yes
|
Yes
|
Yes
|
Yes
|
No ?
|
No
|
No
|
Yes
|
No
|
Yes
|
|
6-OHDA sensitivity:
|
Yes
|
Yes
|
Yes
|
Yes
|
Low
|
No
|
No
|
Yes
|
?
|
Yes
|
|
Synthesis-modulating
autoreceptor:
|
Yes
|
Yes
|
No
|
Yes
|
No
|
No
|
Yes/no
(mixed)c
|
Yes
|
?
|
Yes
|
|
Tyrosine dependency-
basal:
|
No
|
No
|
Yes
|
?
|
?
|
?
|
?
|
?
|
?
|
No
|
|
Tyrosine dependency-
activated:
|
Yes
|
Yes
|
Yes
|
?
|
Yes
|
?
|
?
|
?
|
?
|
Yes
|
|
Response to agonist
(decrease in DA
synthesis,
catabolism, turnover):
|
Yes
|
Yes
|
Yes
(small)
|
Yes
|
Yes
|
Yes
(delayed)
|
Yes
|
Yes
|
?
|
Yes
|
|
Response to antagonist
(increase DA synthesis,
catabolism, turnover):
|
Yes
|
Yes
|
Yes
(small)
|
Yes
|
Yes
|
Yes
(delayed)
|
Yes
|
Yes
|
?
|
Yes
|
|
Tolerance to chronic
typical
neuroleptic:
|
Marked
|
Yes
|
Less
|
?
|
Yes/no
(mixed)c
|
No
|
No
|
?
|
?
|
Less
|
|
Response to mild stress
(BZ-sensitive, increase
in synthesis and
metabolism):
|
No
|
Yes
(shell)
|
Yes
|
No
|
Yes/no
(mixed)c
|
No
|
No
|
?
|
?
|
?
|
|
Response to beta
cabolines
(increase in DA
catabolism):
|
No
|
No (core)
Yes
(shell)
|
Yes
|
No
|
No
|
?
|
?
|
?
|
?
|
?
|
|
Psychostimulant
sensitization
(augmentation of DA
release):
|
Moderate
|
High
|
Low
|
?
|
?
|
?
|
?
|
?
|
?
|
?
|
|
Cocaine withdrawal
(decrease in Bmax for
transporter):
|
No
|
?
|
Yes
|
?
|
?
|
?
|
?
|
?
|
?
|
?
|
|
|
a For references, see citations in text; also see
refs. 10 and 35.
b Abbreviations: N-STR, nigrostriatal; M-ACC, mesoaccumbens;
M-PRF, mesoprefrontal; M-PIR, mesopiriform; M-AMY, mesoamygdaloid; TINF,
tuberoinfundibular; THYP, tuberohypophyseal; IHYP, incertohypothalamic;
OLF-B, olfactory bulb; RETN, retina; interm., intermediate.
c Mixed indicates that the response differs
within the category, depending on the neuronal subset examined.
|