The Dopamine Transporter : Potential Involvement in Neuropsychiatric Disorders / Table 1

TABLE 1. Comparison of the Ki values of drugs at cloned and native dopamine transportersa

Drug	Cloned human dopamine transporterb	Cloned rat dopamine transporterb	Rat striatal synaptosomesc
Dopamine	1220	890, 885,d 1190e	105, 300
Mazindol	11	23, 70,d 30e	85, 280
GBR 12783	13	22	2
GBR 12209	17	17	51
Nomifensine	17	60, 150d	50, 100, 220, 780, 48, 85
Benztropine	55	109	170, 100
Cocaine	58	330, 2000,d 1000e	310, 670, 1400
Amfebutamone	330	521	600
d-Amphetamine	2260	2160	240, 980, 640
Desipramine	13,000	12,000	20,000
l-Amphetamine	22,000	22,600	2900
MPP+	23,000	23,000	400

a From ref. (25), with permission. Note the lower affinity of the heterologously expressed transporters for various substrates.

b Data taken from ref. (27).

c Data taken from ref. (36).

d Data taken from ref. (49).

e Data taken from ref. (81).

published 2000