The Dopamine Transporter: Potential Involvement in Neuropsychiatric
Disorders
Michael J. Bannon, Paola Sacchetti and James G. Granneman
Department of Psychiatry and Behavioral Neurosciences
Wayne State University School of Medicine
2309 Scott Hall, 540 E. Canfield Avenue
Detroit, Michigan 48201
telephone: (313) 577-5949
fax: (313) 993-4269
e-mail: mbannon@med.wayne.edu
REFERENCES
- Allard PO, Marcusson JO. Age-correlated loss of dopamine uptake sites labeled
with [3H]GBR-12935 in human putamen. Neurobiol Aging 1989;10:661-664.
- Allard PO, Rinne J, Marcusson JO. Dopamine uptake sites in Parkinson’s disease
and in dementia of the Alzheimer type. Brain Res 1994;637:262-266.
- Amara SG, Arriza JL. Neurotransmitter transporters: three distinct gene
families. Curr Opin Neurobiol 1993;3:337-344.
- Bannon MJ, Granneman JG, Kapatos G. The dopamine transporter. In: Bloom
FE, Kupfer DJ, eds. Psychopharmacology: the fourth generation of progress.
New York: Raven Press, 1995;179-188.
- Bannon MJ, Poosch MS, Xia Y, Goebel DJ, Cassin B, Kapatos G. Dopamine transporter
mRNA content in human substantia nigra decreases precipitously with age. Proc
Natl Acad Sci USA 1992;89:7095-7099.
- Bannon MJ, Whitty CJ. Age-related and regional differences in dopamine transporter
mRNA expression in human midbrain. Neurol 1997;48:969-977.
- Berger SP, Farrell K, Conant D, Kempner ES, Paul SM. Radiation inactivation
studies of the dopamine reuptake transporter protein. Mol Pharm 1994;46:726-731.
- Biederman J, Faraone SV, Keenan K, Knee D, Tsuang MT. Family-genetic and
psychosocial risk factors in DMS-III attention deficit disorder. J Am Acad
Child Adolesc Psychiat 1990;29:526-533.
- Buck KJ, Amara SG. Chimeric dopamine-norepinephrine transporters delineate
structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium.
Proc Natl Acad Sci USA 1994;91:12584-12588.
- Buck KJ, Amara SG. Structural domains of catecholamine transporter chimeras
involved in selective inhibition by antidepressants and psychomotor stimulants.
Mol Pharm 1995;48:1030-1037.
10a. Bull PC, Thomas GR, Rommens JM, Forbes JR, Cox DW. The Wilson disease
gene is a putative copper transporting P-type ATPase similar to the Menkes
gene. Nat Genet 1993;5:327-337.
- Byerley W, Coon H, Hoff M, Waldo M, Freedman R, Caron MG, Giros B. Human
dopamine transporter gene not linked to schizophrenia in multigenerational
pedigrees. Hum Hered 1993;43:319-322.
- Byerley W, Hoff M, Holik J, Caron MG, Giros B. VNTR polymorphism for the
human dopamine transporter gene (DAT1). Hum Molec Genet 1993;2:335.
- Bruss M, Hammermann R, Brimijoin S, Bonisch H. Antipeptide antibodies confirm
the topology of the human norepinephrine transporter. J Biol Chem 1995;270:9197-201.
- Cass WA, Gerhardt GA. Direct in vivo evidence that D2 dopamine receptors
can modulate dopamine uptake. Neurosci Lett 1994;17:259-63.
- Castillo SO, Baffi JS, Palkovits M, Goldstein DS, Kopin IJ, Witta J, Magnuson
MA, Nikodem VM. Dopamine biosynthesis is selectively abolished in substantia
nigra/ventral tegmental area but not in hypothalamic neurons in mice with
targeted disruption of the Nurr1 gene. Mol Cell Neurosc 1998;11:36-46.
- Chinaglia G, Alvarez FJ, Probst A, Palacios JM. Mesostriatal and mesolimbic
dopamine uptake binding sites are reduced in Parkinson’s disease and progressive
supranuclear palsy: a quantitative autoradiographic study using [3H]
Mazindol. Neurosc 1992;49:317-327.
- Ciliax BJ, Heilman C, Demchyshyn LL, Pristupa ZB, Ince E, Hersch SM, Niznik
HB, Levey AI. The dopamine transporter: immunochemical characterization and
localization in brain. J Neurosc 1995;15:1714-1723.
- Cook EH, Stein MA, Krasowski MD, Cox NJ, Olkon DM, Kieffer JE, Leventhal
BL. Association of attention-deficit disorder and the dopamine transporter
gene. Am J Hum Genet 1995;56:993-998.
- Daniels J, Williams J, Asherson P, McGuffin P, Owen M. No association between
schizophrenia and polymorphisms within genes for debrisoquine 4-hydroxylase
(CYP2D6) and the dopamine transporter (DAT). Am J Med Genet 1995;60:85-87.
- De Keyser J, Ebinger G, Vauquelin G. Age-related changes in the human nigrostriatal
dopaminergic system. Ann Neurol 1990;27:157-161.
- Donovan DM, Vanderbergh DJ, Perry MP, Bird GS, Ingersoll R, Nanthakumar
E, Uhl GR. Human and mouse dopamine transporter genes: conservation of 5'-flanking
sequence elements and gene structures. Mol Brain Res 1995;30:327-335.
- Doucette-Stamm L, Blakely DJ, Tian J, Mockus S, Mao J. Population genetic
study of the human dopamine transporter gene (DAT1). Genet Epidemiol 1995;12:303-308.
- Ernst M, Zametkin AJ, Matochik JA, Pascualvaca D, Jons PH, Hardy K, Hankerson
JG, Doudet DJ, Cohen RM. Presynaptic dopaminergic deficits in Lesch-Nyhan
disease. N Engl J Med 1996;334:1568-1572.
- Fischman AJ, Bonab AA, Babich JW, Prather Palmer E, Alpert NM, Elmaleh DR,
Callahan RJ, Barrow SA, Graham W, Meltzer PC, Hanson RN, Madras BK. Rapid
detection of Parkinson’s disease by SPECT with altropane: a selective ligand
for dopamine transporters. Synapse 1998;29:128-141.
- Freed C, Revay R, Vaughan RA, Kriek E, Grant S, Uhl GR, Kuhar MJ. Dopamine
transporter immunoreactivity in rat brain. J Comp Neurol 1995;359:340-349.
- Frost JJ, Rosier AJR, Reich SG, Smith JS, Ehlers MD, Snyder SH, Ravert HT,
Dannals RF. Positron emission tomographic imaging of the dopamine transporter
with 11C-WIN 35,428 reveals marked declines in mild Parkinson’s
disease. Ann Neurol 1993;34:423-431.
- Fujiwara Y, Yamaguchi K, Tanaka Y, Tomita H, Shiro Y, Kashihara K, Sato
K, Kuroda S. Polymorphism of dopamine receptors and transporter genes in neuropsychiatric
diseases. Eur Neurol 1997;38:6-10.
- Fumagalli F, Gainetdinov RR, Valenzano KJ, Caron MC. Role of dopamine transporter
in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter.
J Neurosc 1998;18:4861-4869.
- Gainetdinov RR, Fumagalli F, Jones SR, Caron MG. Dopamine transporter is
required for in vivo MPTP neurotoxicity: evidence from mice lacking
the transporter. J Neurochem 1997;69:1322-1325.
- Gelernter J, Vandenbergh D, Kruger SD, Pauls DL, Kurlan R, Pakstis AJ, Kidd
KK, Uhl GR. The dopamine transporter protein gene (SLC6A3): primary linkage
mapping and linkage studies in Tourette syndrome. Genomics 1995;30:459-463.
- Gill M, Daly G, Heron S, Hawi Z, Fitgerald M. Confirmation of association
between attention deficit hyperactivity disorder and a dopamine transporter
polymorphism. Molec Psychiat 1997;2:311-313.
- Gillis JJ, Gilger JW, Pennington BF, DeFries JC. Attention deficit disorder
in reading disabled twins: evidence for a genetic etiology. J Abnorm Child
Psych 1992;20:343-348.
- Giros B, Caron MG. Molecular characterization of the dopamine transporter.
Trends Pharmacol Sci 1993;14:43-49.
- Giros B, El Mestikawy S, Bertrand L, Caron MG. Cloning and functional characterization
of a cocaine-sensitive dopamine transporter. FEBS Lett 1991;295:149-154.
- Giros B, El Mestikawy S, Godinot N, Zheng K, Han H, Yang-Feng T, Caron MG.
Cloning, pharmacological characterization, and chromosome assignment of the
human dopamine transporter. Mol Pharm 1992;42:383-390.
- Giros B, Jaber M, Jones SR, Wightman RM, Caron MG. Hyperlocomotion and indifference
to cocaine and amphetamine in mice lacking the dopamine transporter. Nat
1996;379:606-612.
- Giros B, Wang YM, Suter S, McLeskey SB, Pifl C, Caron MG. Delineation of
discrete domains for substrate, cocaine, and tricyclic antidepressant interactions
using chimeric dopamine-norepinephrine transporters. J Biol Chem 1994;269:15985-15988.
- Guttman M, Burkholder J, Kish SJ, Hussey D, Wilson A, DaSilva J, Houle S.
[11C]RTI-32 PET studies of the dopamine transporter in early dopa-naive
Parkinson’s disease: implications for the symptomatic threshold. Neurol
1997;48:1578-1583.
- Haberland N, Hetey L. Studies in postmortem dopamine uptake – II.Alterations
of the synaptosomal catecholamine uptake in postmortem brain regions
in schizophrenia. J Neural Transm 1987;68:303-313.
- Harrington KA, Augood SJ, Kinsbury AE, Foster OJF, Emson PC. Dopamine transporter
(DAT) and synaptic vesicle amine transporter (VMAT2) gene expression in the
substantia nigra of control and Parkinson’s disease. Mol Brain Res
1996;36:157-162.
- Higuchi S, Muramatsu T, Arai H, Hayashida M, Sasaki H, Trojanowski JQ. Polymorphisms
of dopamine receptor and transporter genes and Parkinson’s disease. J Neur
Transm – Park Dis Dement Sect 1995;10:107-113.
- Hitri A, Casanova MF, Kleinman JE, Weinberger DR, Wyatt RJ. Age-related
changes in [3H]GBR 12935 binding site density in the prefrontal
cortex of controls and schizophrenics. Biol Psychiat 1995;37:175-182.
- Huff RA, Vaughan RA, Kuhar MJ, Uhl GR. Phorbol esters increase dopamine
transporter phosphorylation and decrease transport Vmax. J Neurochem
1997;68:225-232.
- Innis RB, Seibyl JP, Scanley BE, Laruelle M, Abi-Dargham A, Wallace E, Baldwin
RM, Zea-Ponce Y, Zoghbi S, Wang S, et al. Single photon emission computed
tomographic imaging demonstrates loss of striatal dopamine transporters in
Parkinson disease. Proc Natl Acad Sci USA 1993;90:11965-9.
- Iversen LL. Role of transmitter uptake mechanisms in synaptic neurotransmission.
Br J Pharmacol 1971;41:571-591.
- Jeon B, Kim JM, Jeong JM, Kim KM, Chang YS, Lee DS, Lee MC. Dopamine transporter
imaging with [123I]-b -CIT demonstrates
presynaptic nigrostriatal dopaminergic damage in Wilson’s disease. J Neurol,
Neurosurg Psychiatry 1998;65:60-64.
- Jinnah HA, Wojcik BE, Hunt M, Narang N, Lee KY, Goldstein M, Wamsley JK,
Langlais PJ, Friedmann T. Dopamine deficiency in a genetic mouse model of
Lesch-Nyhan disease. J Neurosc 1994;14:1164-1175.
- Jones SR, Gainetdinov RR, Wightman RM, Caron MG. Mechanisms of amphetamine
action revealed in mice lacking the dopamine transporter. J Neurosc 1998;18:1979-1986.
- Joyce JN, Smutzer G, Whitty CJ, Myers A, Bannon MJ. Differential modification
of dopamine transporter and tyrosine hydroxylase mRNAs in midbrain of subjects
with Parkinson’s, Alzheimer’s with parkinsonism, and Alzheimer’s disease.
Mov Disord 1997;12:885-897.
- Kawarai T, Kawakami H, Yamamura Y, Nakamura S. Structure and organization
of the gene encoding human dopamine transporter. Gene 1997;195:11-18.
- Kelsoe JR, Sadovnick AD, Krisrbjarnarson H, Bergesch P, Mroczkowski-Parker
Z, Drennan M, Rapaport MH, Flodman P, Spence MA, Remick RA. Possible locus
for bipolar disorder near the dopamine transporter on chromosome 5. Am
J Med Genet 1996;67:533-540.
- King N, Bassett AS, Honer WG, Masellis M, Kennedy JL. Absence of linkage
for schizophrenia on the short arm of chromosome 5 in multiplex canadian families.
Am J Med Genet 1997;74:472-474.
- Kitayama S, Shimada S, Xhu H, Markham L, Donovan DM, Uhl GR. Dopamine transporter
site-directed mutations differentially alter substrate transport and cocaine
binding. Proc Natl Acad Sci USA 1992;89:7782-7785.
- Kitayama S, Wang JB, Uhl GR. Dopamine transporter mutants selectively enhance
MPP+ transport. Synapse 1993;15:58-62.
- Kilty JE, Lorang D, Amara S. Cloning and expression of a cocaine-sensitive
rat dopamine transporter. Science 1991;254:578-579.
- Kouzmenko AP, Pereira AM, Singh BS. Intronic sequences are involved in neuronal
targeting of human dopamine transporter gene expression. Biochem Biophys
Res Comm 1997;240:807-811.
- Le Couteur DG, Leighton PW, McCann SJ, Pond SM. Association of a polymorphism
in the dopamine-transporter gene with Parkinson’s disease. Movement Disord
1997;12:760-763.
- Leighton PW, Le Couteur DG, Pang CC, McCann SJ, Chan D, Law LK, Kay R, Pond
SM, Woo J. The dopamine transporter gene and Parkinson’s disease in a Chinese
population. Neurol 1997;49:1577-1579.
- Lester HA, Mager S, Quick MW, Corey JL. Permeation properties of neurotransmitter
transporters. Ann Rev Pharm Tox 1994;34:219-249.
- Little KY, Carroll FI, Butts JD. Striatal [125I]RTI-55 binding
sites in cocaine-abusing humans. Prog Neuro-Psychopharm Biol Psychiat 1998;22:455-466.
- Little KY, Kirkman JA, Carroll FI, Clark TB, Duncan GE. Cocaine use increases
[3H]WIN 35428 binding sites in human striatum. Brain Res 1993;628:17-25.
- Lorang D, Amara SG, Simerly RB. Cell-type-specific expression of catecholamine
transporters in the rat brain. J Neurochem 1994;14:4903-4914.
- Ma SY, Ciliax BJ, Stebbins G, Jaffar S, Joyce JN, Cochran EJ, Kordower JH,
Mash DC, Levey AI, Mufson EJ. Dopamine transporter immunoreactive neurons
decrease with age in human substantia nigra. Comp Neurol 1998, in press.
- Malison RT, McDougle CJ, van Dick CH, Scahill L, Baldwin RM, Seibyl JP,
Price LH, Leckman JF, Innis RB. [123I]b
-CIT SPECT imaging of striatal dopamine transporter binding in Tourette’s
disorder. Am J Psychiat 1995;152:1359-1361.
- Malison RT, Best SE, van Dick CH, McCance EF, Wallace EA, Laruelle M, Baldwin
RM, Seibyl JP, Price LH, Kosten TR, Innis RB. Elevated striatal dopamine transporters
during acute cocaine abstinence as measured by [123I]b
-CIT SPECT. Am J Psychiat 1998;155:832-834.
- Maloteaux JM, Vanisberg MA, Laterre C, Javoy-Agid F, Agid I, Laduron PM.
[3H]GBR 12935 binding to dopamine uptake sites: subcellular localization
and reduction in Parkinson’s disease and progressive supranuclear palsy. Eur
J Pharm 1988;156:331-340.
- McCann UD, Wong DF, Yokoi F, Villemagne V, Dannals RF, Ricaurte GA. Reduced
striatal dopamine transporter density in abstinent methamphetamine and methcathinone
users: evidence from positron emission tomography studies with [11C]WIN-35,428.
J Neurosc 1998;18:8417-8422.
- McGeer PL, McGeer EG, Suzuki JS. Aging and extrapyramidal function. Arch
Neurol 1977;34:33-35.
- Meiergard SM, Patterson TA, Schenk JO. D2 receptors may modulate
the function of the striatal transporter for dopamine: kinetic evidence from
studies in vitro and in vivo. J Neurochem 1993;61:764-767.
- Meister B, Elde R. Dopamine transporter mRNA in neurons of the rat hypothalamus.
Neuroendocr 1993;58:388-95.
- Miller GW, Staley JK, Heilman CJ, Perez JT, Mash DC, Rye DB, Levey AI. Immunochemical
analysis of dopamine transporter protein in Parkinson’s disease. Ann Neurol
1997;41:530-539.
- Milner HE, Beliveau R, Jarvis SM. The in situ size of the dopamine transporter
is a tetramer as estimated by radiation inactivation. Biochem Biophys Acta
1994;1190:185-187.
- Mitsuhata C, Kitayama S, Morita K, Vandenbergh D, Uhl GR, Dohi T. Tyrosine-533
of rat dopamine transporter: involvement in interactions with 1-methyl-4-phenylpyridinium
and cocaine. Mol Brain Res 1998;56:84-88.
- Murray AM, Weihmueller FB, Marshall JF, Hurtig HI, Gottleib GL, Joyce JN.
Damage to dopamine systems differs between Parkinson’s disease and Alzheimer’s
with parkinsonism. Ann Neurol 1995;37:300-312.
- Nakamura Y, Koyama K, Matsushima M. VNTR (variable number of tandem repeat)
sequences as transcriptional, translational, or functional regulators. J
Hum Genet 1998;43:149-52.
- Nakatome M, Honda K, Tun Z, Kato Y, Harihara S, Omoto K, Misawa S, Gerelsaikhan
T, Nyamkhishig S, Dashnyam B, Batsuuri J, Wakasugi C. Genetic polymorphism
of the 3’ VNTR region of the human dopaminergic function gene DAT1 (human
dopamine transporter gene) in the Mongolian population. Hum Biol 1996;68:509-15.
- Nelson N. The family of Na+/Cl- neurotransmitter transporters.
J Neurochem 1998;71:1785-1803.
- Nirenberg MJ, Chan J, Pohorille A, Vaughan RA, Uhl GR, Kuhar MJ, Pickel
VM. The dopamine transporter: comparative ultrastructure of dopaminergic axons
in limbic and motor compartments of the nucleus accumbens. J Neurosc
1997;17:6899-6907.
- Nirenberg MJ, Vaughan RA, Uhl GR, Kuhar MJ, Pickel VM. The dopamine transporter
is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic
neurons. J Neurosc 1996;16:436-447.
- Norlen M, Allard P. Reduction in number of dopamine uptake sites but unchanged
number in piperazine-acceptor/CYP450IID6 binding sites in the human caudate
nucleus in aging. Neurosc Lett 1996;209:161-164.
- Parsian A, Zhang ZH. Human dopamine transporter gene polymorphism (VNTR)
and alcoholism. Am J Med Genet 1997;74:480-482.
- Parsons LH, Schad CA, Justice JB Jr. Co-administration of the D2 antagonist
pimozide inhibits up-regulation of dopamine release and uptake induced by
repeated cocaine. J Neurochem 1993;60:376-9.
- Patel AP. Neurotransmitter transporter proteins: posttranslational modifications.
In: Reith MEA, ed. Neurotransmitter transporters: structure, function,
and regulation. Totowa: Humana Press, 1997;241-262.
- Persico AM, Vandenbergh DJ, Smith SS, Uhl GR. Dopamine transporter gene
polymorphisms are not associated with polysubstance abuse. Biol Psychiat
1993;34:265-267.
- Plante-Bordeneuve V, Taussig D, Thomas F, Said G, Wood NW, Marsden CD, Harding
AE. Evaluation of four candidate genes encoding proteins of the dopamine pathway
in familial and sporadic Parkinson’s disease: evidence for association of
a DRD2 allele. Neurol 1997;48:1589-1593.
- Povlock SL, Amara SG. The structure and function of norepinephrine, dopamine
and serotonin transporters. In: Reith MEA, ed. Neurotransmitter transporters:
structure, function, and regulation. Totowa: Humana Press, 1997;1-28.
- Pristupa ZB, McConkey F, Liu F, Man HY, Lee FJS, Wang YT, Niznik HB. Protein
kinase-mediated bidirectional trafficking and functional regulation of the
human dopamine transporter. Synapse 1998;30:79-87.
- Rocha BA, Fumagalli F, Gainetdinov RR, Jones SR, Ator R, Giros B, Miller
GW, Caron MG. Cocaine self-administration in dopamine-transporter knockout
mice. Nat Neurosc 1998;1:132-137.
- Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ. Cocaine receptors on dopamine transporters
are related to self-administration of cocaine. Science 1987;237:1219-1223.
- Rudnick G. Mechanisms of biogenic amine neurotransmitter transporters. In:
Reith MEA ed. Neurotransmitter transporters: structure, function, and regulation.
Totowa: Humana Press, 1997;73-100.
- Sacchetti P, Brownschidle LA, Granneman JG, Bannon MJ. Characterization
of the promoter region of the human dopamine transporter. Soc Neurosc Abstr
1998;24:241.1.
- Sakurada MO, Palmer TD, Gage FH. Regulation of dopaminergic differentiation
in stem cells derived from adult brain by the SHH and Nurr1 signaling pathway.
Soc Neurosc Abstr 1998;24:313.13.
- Sanghera MK, Manaye KF, Liang CL, Iacopino AM, Bannon MJ, German DC. Low
dopamine transporter mRNA levels in midbrain regions containing calbindin.
Neurorep 1994;5:1641-1644.
- Sano A, Kondoh K, Kakimoto Y, Kondo I. A 40-nucleotide repeat polymorphism
in the human dopamine transporter gene. Hum Genet 1993;91:405-406.
- Saucedo-Cardenas O, Quintana-Hau JD, Le WD, Smidt MP, Cox JJ, De Mayo F,
Burbach JPH, Conneely OM. Nurr1 is essential for the induction of the dopaminergic
phenotype and the survival of ventral mesencephalic late dopaminergic precursor
neurons. Proc Natl Acad Sci USA 1998;95:4013-4018.
- Scherman D, Desnos C, Darchen F, Pollak P, Javoy-Agid F, Agid I. Striatal
dopamine deficiency in Parkinson’s disease: role of aging. Ann Neurol 1989;26:551-557.
- Seeman P, Niznik HB. Dopamine receptors and transporters in Parkinson’s
disease and schizophrenia. FASEB J 1990;4:2737-2744.
- Shimada S, Kitayama S, Lin CL, Patel A, Nanthakumar E, Gregor P, Kuhar M,
Uhl GR. Cloning and expression of a cocaine-sensitive dopamine transporter
complementary DNA. Science 1991;254:576-578.
- Singer HS, Hahn IH, Moram TH. Abnormal dopamine uptake sites in postmortem
striatum from patients with Tourette’s syndrome. Ann Neurol 1991;30:558-562.
- Sonders MS, Zhu SJ, Zahniser NR, Kavanaugh MP, Amara SG. Multiple ionic
conductances of the human dopamine transporter: the actions of dopamine and
psychostimulants. J Neurosc 1997;17:960-974.
- Sora I, Wichems C, Takahashi N, Li XF, Zheng Z, Revay R, Lesch KP, Murphy
DL, Uhl GR. Cocaine reward models: conditioned place preference can be established
in dopamine- and in serotonin-transporter knockout mice. Proc Natl Acad
Sci USA 1998;95:7699-7704.
- Staley JK, Hearn WL, Ruttenber AJ, Wetli CV, Mash DC. High affinity cocaine
recognition sites on the dopamine transporter are elevated in fatal cocaine
overdose victims. J Pharm Exp Ther 1994;271:1678-1685.
- Staley JK, Talbot JZ, Ciliax BJ, Miller GW, Levey AI, Kung MP, Kung HF,
Mash DC. Radioligand binding and immunoautoradiographic evidence for a lack
of toxicity to dopaminergic nerve terminals in human cocaine overdose victims.
Brain Res 1997;747:219-229.
- Tissingh G, Bergmans P, Booij J, Winogrodzka A, van Royen EA, Stoof JC,
Wolters EC. Drug-naive patients with Parkinson’s disease in Hoehn and Yahr
stages I and II show a bilateral decrease in striatal dopamine transporters
as revealed by [123I]b -CIT SPECT.
J Neurol 1998 ;245:14-20.
- Uhl GR. Hypothesis: the role of dopaminergic transporters in selective vulnerability
of cells in Parkinson’s disease. Ann Neurol 1998;43:555-560.
- Uhl GR, Walther D, Mash D, Faucheux B, Javoy-Agid F. Dopamine transporter
messenger RNA in Parkinson’s disease and control substantia nigra neurons.
Ann Neurol 1994;35:494-498.
- Usdin TB, Mezey E, Chen C, Browstein MJ, Hoffman BJ. Cloning of the cocaine-sensitive
bovine dopamine transporter. Proc Natl Acad Sci USA 1991;88:11168-11171.
- Vandenbergh DJ, Persico AM, Hawkins AL, Griffin CA, Li X, Jabs EW, Uhl GR.
Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays
a VNTR. Genomics 1992;14:1104-1106.
- Vandenbergh DJ, Persico AM, Uhl GR. A human dopamine transporter cDNA predicts
reduced glycosilation, displays a repetitive element and provides racially-dimorphic
Taq I RFLPs. Mol Brain Res 1992;15:161-166.
- van Dick CH, Seibyl JP, Malison RT, Laruelle M, Wallace E, Zoghbi SS, Zea-Ponce
Y, Baldwin RM, Charney DS, Hoffer PB, Innis RB. Age-related decline in striatal
dopamine transporter binding with Iodine-123-b
-CIT SPECT. J Nuclear Med 1995;36:1175-1181.
- Vaughan RA, Huff RA, Uhl GR, Kuhar MJ. Protein kinase C-mediated phosphorylation
and functional regulation of dopamine transporters in striatal synaptosomes.
J Biol Chem 1997;272:15541-15546.
- Vaughan RA, Kuhar MJ. Dopamine transporter ligand binding domains. J
Biol Chem 1996;271:21672-21680.
- Volkow ND, Ding YS, Fowler JS, Wang GJ, Logan J, Gatley SJ, Hitzemann R,
Smith G, Fields SD, Gur R. Dopamine transporters decrease with age. J Nuclear
Med 1996;37:554-559.
- Volkow ND, Fowler JS, Wang GJ, Logan J, Schlyer D, MacGregor R, Hitzemann
R, Wolf AP. Decreased dopamine transporters with age in healthy human subjects.
Ann Neurol 1994;36:237-239.
- Volkow ND, Wang GJ, Fischman MW, Foltin RW, Fowler JS, Abumrad NN, Vitkun
S, Logan J, Gatley SJ, Pappas N, Hitzemann R, Shea CE. Relationship between
subjective effects of cocaine and dopamine transporter occupancy. Nat 1997;386:827-830.
- Volkow ND, Wang GJ, Fowler JS, Logan J, Gatley SJ, Hitzemann R, Chen AD,
Dewey SL, Pappas N. Decreased striatal dopaminergic responsiveness in detoxified
cocaine-dependent subjects. Nat 1997;386:830-833.
- Waldman ID, Rowe DC, Abramowitz A, Kozel ST, Mohr JH, Sherman SL, Cleveland
HH, Sanders ML, Gard JM, Stever C. Association and linkage of the dopamine
transporter gene and attention-deficit hyperactivity disorder in children:
heterogeneity owing to diagnostic subtype and severity. Am J Hum Genet
1998;63:1767-1776.
- Wang GJ, Volkow ND, Fowler JS, Fischman M, Foltin R, Abumrad NN, Logan J,
Pappas NR. Cocaine abusers do not show loss of dopamine transporters with
age. Life Sci 1997;61:1059-1065.
- Westermark K, Tedroff J, Thuomas KA, Hartvig P, Langstrom B, Andersson Y,
Hornfeldt K, Aquilonius SM. Neurological Wilson's disease studied with magnetic
resonance imaging and with positron emission tomography using dopaminergic
markers. Mov Disord 1995;10:596-603.
- Wilson JM, Kalasinky KS, Levey AI, Bergeron C, Reiber G, Anthony RM, Schmunk
GA, Shannak K, Haycock JW, Kish SJ. Striatal dopamine nerve terminal markers
in human, chronic methamphetamine users. Nat Med 1996;2:699-703.
- Wilson JM, Levey AI, Bergeron C, Kalasinsky K, Ang L, Peretti F, Adams VI,
Smialek J, Anderson WR, Shannak K, Deck J, Niznik HB, Kish SJ. Striatal dopamine,
dopamine transporter, and vesicular monoamine transporter in chronic cocaine
users. Ann Neurol 1996;40:428-439.
- Wolraich ML, Hannah JN, Pinnock TY, Baumgaertel A, Brown J. Comparison of
diagnostic criteria for attention-deficit hyperactivity disorder in a county-wide
sample. J Am Acad Child Adolesc Psych 1996;35:319-324.
- Wong DF, Harris JC, Naidu S, Yokoi F, Marenco S, Dannals RF, ravert HT,
Yasters M, Evans A, Rousset O, Bryan RN, Gjedde A, Kuhar MJ, Breese GR. Dopamine
transporters are markedly reduced in Lesch-Nyhan disease in vivo. Proc
Natl Acad Sci USA 1996;93:5539-5543.
- Wong DF, Ricaurte G, Grunder G, Rothman R, Naidu S, Singer H, Harris J,
Yokoi F, Villemagne V, Szymanski S, Gjedde A, Kuhar M. Dopamine transporter
changes in neuropsychiatric disorders. Adv Pharm 1998;42:219-223.
- Xia Y, Goebel DJ, Kapatos G, Bannon MJ. Quantitation of rat dopamine transporter
mRNA: effects of cocaine treatment and withdrawal. J Neurochem 1992;59:1179-1182.
- Zelnik N, Angel I, Paul SM, Kleinman JE. Decreased density of human striatal
dopamine uptake sites with age. Eur J Pharm 1986;126:175-176.
- Zetterstrom RH, Solomin L, Jansson L, Hoffer BH, Olson L, Perlmann T. Dopamine
neuron agenesis in Nurr1-deficient mice. Science 1997;276:248-250.
- Zhu SJ, Kavanaugh MP, Sonders MS, Amara SG, Zahniser NR. Activation of protein
kinase C inhibits uptake, currents and binding associated with the human dopamine
transporter expressed in Xenopus Oocytes. J Pharmacol Exp Ther 1997;282:1358-1365.
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published 2000